INT11918

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Context Info
Confidence 0.51
First Reported 1980
Last Reported 2006
Negated 0
Speculated 1
Reported most in Abstract
Documents 35
Total Number 38
Disease Relevance 8.21
Pain Relevance 15.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CGB) small molecule metabolic process (CGB) extracellular region (CGB)
cellular nitrogen compound metabolic process (CGB) cell-cell signaling (CGB)
Anatomy Link Frequency
tonsil 3
gonadal 2
intermediary 1
neurons 1
thoracic 1
CGB (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 151 99.92 Very High Very High Very High
Endogenous opioid 23 99.92 Very High Very High Very High
opioid receptor 9 99.90 Very High Very High Very High
Opioid 35 99.84 Very High Very High Very High
Morphine 13 99.70 Very High Very High Very High
antagonist 26 99.60 Very High Very High Very High
Serotonin 1 99.60 Very High Very High Very High
opiate 25 99.56 Very High Very High Very High
Dopamine 5 99.54 Very High Very High Very High
Enkephalin 5 99.50 Very High Very High Very High
Disease Link Frequency Relevance Heat
Skin Cancer 19 99.98 Very High Very High Very High
Aging 2 99.84 Very High Very High Very High
Syndrome 1 99.64 Very High Very High Very High
Cancer 14 99.48 Very High Very High Very High
Hydronephrosis 6 99.48 Very High Very High Very High
Metastasis 12 99.06 Very High Very High Very High
Endometriosis (extended) 2 97.28 Very High Very High Very High
Recurrence 4 95.68 Very High Very High Very High
Germ Cell And Embryonal Neoplasms 4 95.44 Very High Very High Very High
Precocious Puberty 7 95.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A case of retroperitoneal metastasis from a squamous cell carcinoma of the tonsil, secreting beta human chorionic gonadotrophin (beta-hCG), is reported.
Localization (secreting) of beta-hCG in tonsil associated with skin cancer and metastasis
1) Confidence 0.51 Published 2006 Journal J Laryngol Otol Section Abstract Doc Link 16716237 Disease Relevance 1.15 Pain Relevance 0.09
To our knowledge, this is the first reported case of retroperitoneal metastasis from a squamous cell carcinoma of the tonsil, secreting beta-hCG and causing hydronephrosis.
Localization (secreting) of beta-hCG in tonsil associated with hydronephrosis, skin cancer and metastasis
2) Confidence 0.51 Published 2006 Journal J Laryngol Otol Section Abstract Doc Link 16716237 Disease Relevance 1.15 Pain Relevance 0.11
A case of retroperitoneal metastasis from a squamous cell carcinoma of the tonsil, secreting beta human chorionic gonadotrophin (beta-hCG), is reported.
Localization (secreting) of gonadotrophin in tonsil associated with skin cancer and metastasis
3) Confidence 0.51 Published 2006 Journal J Laryngol Otol Section Abstract Doc Link 16716237 Disease Relevance 1.10 Pain Relevance 0.08
Laboratory analyses (suppressed gonadotropins, elevated testosterone) and thoracic CT demonstrated a beta-human chorionic gonadotropin (beta-hCG) and alpha(1)-feto protein (alpha-FP) secreting mediastinal tumor.
Localization (secreting) of gonadotropin in thoracic associated with cancer
4) Confidence 0.48 Published 2006 Journal Am. J. Med. Genet. A Section Abstract Doc Link 16470792 Disease Relevance 2.22 Pain Relevance 0.07
Viability parameters demonstrated that functional integrity of the tissue and its responsiveness to the modulation of human chorionic gonadotropin release by opioids are fully preserved during the 3 days of culture.
Localization (release) of chorionic gonadotropin associated with opioid
5) Confidence 0.39 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7791132 Disease Relevance 0 Pain Relevance 0.72
However, it resulted in the development of opioid tolerance, as demonstrated by a shift to the right in the concentration-response curve of U-69,593-induced stimulation of human chorionic gonadotropin release, and irresponsiveness to the inhibitory action of the antagonist nor-binaltorphimine.
Localization (release) of chorionic gonadotropin associated with antagonist, tolerance and opioid
6) Confidence 0.39 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7791132 Disease Relevance 0 Pain Relevance 0.85
We report here that another opioid-regulated placental function, the release of human chorionic gonadotropin (hCG), depends on extracellular calcium and the modality of its influx via L-type channels.
Localization (release) of chorionic gonadotropin associated with opioid
7) Confidence 0.35 Published 1998 Journal J. Mol. Neurosci. Section Abstract Doc Link 9770647 Disease Relevance 0 Pain Relevance 0.44
In vitro human growth hormone increases human chorionic gonadotropin and progesterone secretion by human placenta at term: evidence of a modulatory role by opioids.
Localization (secretion) of chorionic gonadotropin in placenta associated with narcan and opioid
8) Confidence 0.26 Published 1995 Journal Gynecol. Endocrinol. Section Title Doc Link 7502693 Disease Relevance 0 Pain Relevance 0.48
The inhibitory action of endogenous opioids on gonadotrophin release is now well documented.
Localization (release) of gonadotrophin associated with endogenous opioid
9) Confidence 0.23 Published 1986 Journal Horm. Metab. Res. Section Abstract Doc Link 3096859 Disease Relevance 0 Pain Relevance 0.35
Administration of oestrogen and anti-oestrogen did not significantly affect the response of gonadotrophins to naloxone infusion and no evidence of consistently antagonistic effects of oestrogen and anti-oestrogen on the naloxone-induced gonadotrophin release was obtained.
Localization (release) of gonadotrophin associated with narcan
10) Confidence 0.23 Published 1986 Journal Horm. Metab. Res. Section Abstract Doc Link 3096859 Disease Relevance 0 Pain Relevance 0.66
This shows that endogenous opioids are probably not intermediary in the negative feedback control of oestrogens on gonadotrophin release in the human male.
Localization (release) of gonadotrophin in intermediary associated with endogenous opioid
11) Confidence 0.23 Published 1986 Journal Horm. Metab. Res. Section Abstract Doc Link 3096859 Disease Relevance 0 Pain Relevance 0.59
As naloxone is thought to exert its action on gonadotrophin release via a disinhibition of endogenous LHRH release, this finding is unexpected.
Localization (release) of gonadotrophin associated with narcan
12) Confidence 0.23 Published 1986 Journal Horm. Metab. Res. Section Abstract Doc Link 3096859 Disease Relevance 0 Pain Relevance 0.54
Since LHRH-producing neurons do not possess oestrogen-receptors, it is likely that some other compound mediates the negative feedback action of oestrogens on the gonadotrophin release in the male.
Localization (release) of gonadotrophin in neurons
13) Confidence 0.23 Published 1986 Journal Horm. Metab. Res. Section Abstract Doc Link 3096859 Disease Relevance 0 Pain Relevance 0.45
This study was undertaken to examine the in vitro effect of morphine on hCG (human chorionic gonadotrophin) and hPL (human placental lactogen) release by 1st and 3rd trimester placental tissue explants.
Localization (release) of chorionic gonadotrophin associated with morphine
14) Confidence 0.21 Published 1988 Journal Life Sci. Section Abstract Doc Link 3362038 Disease Relevance 0 Pain Relevance 0.69
The results suggest a possible interaction between dopamine, opioid receptors and gonadotrophin secretion in man.
Localization (secretion) of gonadotrophin associated with dopamine and opioid receptor
15) Confidence 0.17 Published 1980 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 6784978 Disease Relevance 0 Pain Relevance 0.48
Since identical doses of these antagonists and the opiate agonist have elicited respectively a rise and fall of LH levels in normal cycling women, these findings suggest that an underlying hypothalamic component of defect in endogenous dopamine and opioid control may be responsible for the inappropriate gonadotrophin secretion in this syndrome.
Localization (secretion) of gonadotrophin associated with dopamine, syndrome, antagonist, agonist, opiate and opioid
16) Confidence 0.14 Published 1984 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 6088126 Disease Relevance 0.42 Pain Relevance 0.70
All patients underwent controlled ovarian hyperstimulation employing human menopausal gonadotropin and gonadotropin releasing hormone agonist, given either in the midluteal or early follicular phase.
Localization (releasing) of menopausal gonadotropin
17) Confidence 0.13 Published 1998 Journal J Reprod Med Section Body Doc Link 9749419 Disease Relevance 0 Pain Relevance 0
The effect of long-acting analogue of met-enkephalin (DAMME) and naloxone on gonadotrophin secretion has been investigated in man.
Localization (secretion) of gonadotrophin associated with narcan and enkephalin
18) Confidence 0.09 Published 1981 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 6784982 Disease Relevance 0.10 Pain Relevance 0.45
Fewer cells were immunoreactive for calcitonin gene-related peptide (CGRP), the alpha-subunit of human chorionic gonadotropin, gastrin-releasing peptide, serotonin, methionine-enkephalin and gastrin.
Localization (releasing) of chorionic gonadotropin associated with enkephalin, serotonin and calcitonin gene-related peptide
19) Confidence 0.07 Published 1992 Journal Acta Pathol. Jpn. Section Abstract Doc Link 1609616 Disease Relevance 0.88 Pain Relevance 0.48
We describe a rare case of pulmonary squamous cell carcinoma secreting human chorionic gonadotropin (hCG) and its beta-subunit (beta-hCG) in a young female smoker.
Localization (secreting) of gonadotropin associated with skin cancer
20) Confidence 0.06 Published 2000 Journal Jpn. J. Clin. Oncol. Section Abstract Doc Link 10798545 Disease Relevance 0.41 Pain Relevance 0.08

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