INT119189

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 10.58
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNFRSF10A) transcription factor binding (TNFRSF10A)
TNFRSF10A (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 11 99.70 Very High Very High Very High
cytokine 25 98.76 Very High Very High Very High
Inflammation 103 86.68 High High
cINOD 33 81.84 Quite High
COX-2 inhibitor 52 63.12 Quite High
Bile 1 49.76 Quite Low
agonist 2 32.24 Quite Low
diclofenac 1 30.72 Quite Low
COX2 4 25.00 Low Low
Analgesic 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 191 100.00 Very High Very High Very High
Death 42 100.00 Very High Very High Very High
Glioma 6 99.40 Very High Very High Very High
Stomach Cancer 15 96.48 Very High Very High Very High
Hepatocellular Cancer 5 96.12 Very High Very High Very High
Inflammatory Breast Neoplasms 268 95.52 Very High Very High Very High
Cancer 184 94.40 High High
Toxicity 3 91.32 High High
Adenocarcinoma 7 90.20 High High
Colon Cancer 25 89.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This effect was due to an upregulation of TRAIL receptors (TRAIL R2/DR5 and TRAIL-R1/DR4), together with an ability of the compounds to induce a down-regulation of the anti-apoptotic proteins survivin (IAP) and Bcl-xL [121].
Positive_regulation (upregulation) of DR4 associated with apoptosis
1) Confidence 0.67 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.46 Pain Relevance 0.06
Induction of apoptosis by pectenotoxin-2 is mediated with the induction of DR4/DR5, Egr-1 and NAG-1, activation of caspases and modulation of the Bcl-2 family in p53-deficient Hep3B hepatocellular carcinoma cells.
Positive_regulation (induction) of DR4 associated with hepatocellular cancer, apoptosis and cytokine
2) Confidence 0.67 Published 2008 Journal Oncol. Rep. Section Title Doc Link 18202802 Disease Relevance 0.93 Pain Relevance 0.05
The other 20 upregulated genes encoded growth factors (VEGF, DTR/HB-EGF, IGFBP7, IL-6, ANGPT2, EREG, CCL3/MIP1A, and CCL5/RANTES) or growth factor receptors (TBXA2R, TNFRSF10A/ TRAILR1, and ROBO2), mainly involved in angiogenesis.
Positive_regulation (upregulated) of TRAILR1
3) Confidence 0.42 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.18 Pain Relevance 0.08
The other 20 upregulated genes encoded growth factors (VEGF, DTR/HB-EGF, IGFBP7, IL-6, ANGPT2, EREG, CCL3/MIP1A, and CCL5/RANTES) or growth factor receptors (TBXA2R, TNFRSF10A/ TRAILR1, and ROBO2), mainly involved in angiogenesis.
Positive_regulation (upregulated) of TNFRSF10A
4) Confidence 0.42 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.18 Pain Relevance 0.08
CF elevated the death receptors DR4 and DR5 and triggered both the death receptor and the mitochondrial apoptosis pathways.
Positive_regulation (triggered) of death receptor associated with apoptosis and death
5) Confidence 0.15 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19426686 Disease Relevance 1.16 Pain Relevance 0
We conclude that NAG-1 expression is closely related to DR-4 and DR-5 induction, which could provide a mechanistic basis for the apoptotic effect of COX inhibitors in gastric cancer cells.
Positive_regulation (induction) of DR-4 associated with apoptosis and stomach cancer
6) Confidence 0.06 Published 2004 Journal Carcinogenesis Section Abstract Doc Link 15180942 Disease Relevance 1.13 Pain Relevance 0.28
Moreover, temporal expressions of DR-4 and DR-5 induced by sulindac sulfide were similar to that of NAG-1.
Positive_regulation (induced) of DR-4
7) Confidence 0.05 Published 2004 Journal Carcinogenesis Section Abstract Doc Link 15180942 Disease Relevance 1.02 Pain Relevance 0.32
Forced NAG-1 expression significantly induced apoptosis and DR-4 and DR-5 expression.
Positive_regulation (induced) of DR-4 associated with apoptosis
8) Confidence 0.04 Published 2004 Journal Carcinogenesis Section Abstract Doc Link 15180942 Disease Relevance 0.98 Pain Relevance 0.29
SNU668 cells with ectopic expression of NAG-1 showed markedly elevated subG1 population, induced death receptor-4 (DR-4) and DR-5, and revealed smaller active fragments of caspase-3.
Positive_regulation (induced) of death receptor-4 associated with death
9) Confidence 0.02 Published 2006 Journal Apoptosis Section Abstract Doc Link 16699947 Disease Relevance 0.59 Pain Relevance 0.13
We found that treatment of various gliomas with capsaicin significantly upregulated DR5, a death receptor of TRAIL, and downregulated the caspase inhibitor survivin.
Positive_regulation (upregulated) of death receptor associated with qutenza, death and glioma
10) Confidence 0.00 Published 2010 Journal Carcinogenesis Section Abstract Doc Link 19939880 Disease Relevance 0.94 Pain Relevance 0.63

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