INT119194

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.42
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FGF7) extracellular space (FGF7) extracellular region (FGF7)
Golgi apparatus (FGF7)
Anatomy Link Frequency
keratinocyte 1
FGF7 (Homo sapiens)
Pain Link Frequency Relevance Heat
analgesia 1 71.16 Quite High
Pain 3 54.60 Quite High
Inflammation 2 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 82 99.44 Very High Very High Very High
Stomatitis 2 98.80 Very High Very High Very High
Toxicity 1 93.48 High High
Mucositis 9 83.68 Quite High
Infection 3 71.60 Quite High
Pain 3 54.60 Quite High
Skin Cancer 3 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 3 5.00 Very Low Very Low Very Low
Head & Neck Cancer 3 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In tumour cells, up- as well as down-regulation of KGF mRNA was detected.
Negative_regulation (regulation) of KGF mRNA associated with cancer
1) Confidence 0.43 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.52 Pain Relevance 0
The candidate that is most advanced in terms of drug development is recombinant human keratinocyte growth factor (rHuKGF; palifermin), which in phase III clinical trials was shown to reduce the severity and duration of oral mucositis and improve clinical sequelae.
Negative_regulation (reduce) of rHuKGF in keratinocyte associated with stomatitis
2) Confidence 0.42 Published 2004 Journal Semin. Oncol. Section Abstract Doc Link 15181607 Disease Relevance 0.90 Pain Relevance 0.13

General Comments

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