INT119195

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Context Info
Confidence 0.14
First Reported 2000
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 6.77
Pain Relevance 2.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Cotl1) intracellular (Cotl1) enzyme binding (Cotl1)
cytoplasm (Cotl1)
Anatomy Link Frequency
puncture 10
Cotl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 227 99.30 Very High Very High Very High
Inflammation 39 98.60 Very High Very High Very High
isoflurane 7 98.20 Very High Very High Very High
anesthesia 12 97.76 Very High Very High Very High
ketamine 8 88.48 High High
Catecholamine 2 87.92 High High
withdrawal 4 83.36 Quite High
Neurotransmitter 6 81.00 Quite High
Inflammatory response 17 79.24 Quite High
Inflammatory mediators 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Sepsis 306 99.84 Very High Very High Very High
Gastric Motility Disorder 1 99.68 Very High Very High Very High
INFLAMMATION 54 98.60 Very High Very High Very High
Endotoxemia 8 97.08 Very High Very High Very High
Injury 112 95.92 Very High Very High Very High
Peritonitis 5 88.80 High High
Adult Respiratory Distress Syndrome 36 84.40 Quite High
Cancer 9 83.40 Quite High
Necrosis 9 83.16 Quite High
Adhesions 2 82.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cecal ligation and puncture (CLP) was performed on Sprague-Dawley rats under isoflurane anesthesia with and without intraperitoneal biliverdin injections, which were done before, at the time of CLP, and after CLP.
CLP Binding (ligation) of in CLP associated with anesthesia and isoflurane
1) Confidence 0.14 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16537973 Disease Relevance 0.54 Pain Relevance 0.31
Thirty-two male Sprague–Dawley rats (Charles Rivers Laboratories, Wilmington, MA, USA) weighing 250–350g, were assigned to one of four groups: (1) heated with cecal ligation and perforation (CLP; n = 10); (2) no heat and CLP (n = 10); (3) heat and sham CLP (n = 6); and (4) no heat and sham CLP (n = 6).
CLP Neg (no) Binding (ligation) of
2) Confidence 0.13 Published 2000 Journal Crit Care Section Body Doc Link PMC29035 Disease Relevance 1.12 Pain Relevance 0.19
Recent investigations have shown that in rats subjected to cecum ligation and puncture (CLP) the plasma concentration of ET-1 increases until a maximum has been reached 10 to 12 h after the surgical intervention [3,4].
CLP Binding (ligation) of in puncture
3) Confidence 0.13 Published 2005 Journal Crit Care Section Body Doc Link PMC1413997 Disease Relevance 0.49 Pain Relevance 0.03
In the present study, our aim was to find out if tezosentan reverses the rise in microvascular filtration coefficient (Kfc) in rat lungs that have been isolated and perfused 12 h after cecum ligation and puncture (CLP) or infusion of ET-1.


CLP Binding (ligation) of in puncture
4) Confidence 0.13 Published 2005 Journal Crit Care Section Abstract Doc Link PMC1413997 Disease Relevance 0.17 Pain Relevance 0.03
METHODS: Cecal ligation and puncture (CLP) was used to reproduce septic shock model.
CLP Binding (ligation) of in CLP
5) Confidence 0.09 Published 2004 Journal Zhongguo Wei Zhong Bing Ji Jiu Yi Xue Section Body Doc Link 15182446 Disease Relevance 0.20 Pain Relevance 0
Sepsis model of cecal ligation and puncture (CLP)
CLP Binding (ligation) of in CLP associated with sepsis
6) Confidence 0.04 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1989035 Disease Relevance 0.89 Pain Relevance 0.31
We [6] and Kovarik et al. [7] reported that systemic levels of norepinephrine (NE) increased significantly after the onset of sepsis, induced by cecal ligation and puncture (CLP).
CLP Binding (ligation) of in puncture associated with sepsis
7) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677660 Disease Relevance 1.02 Pain Relevance 0.17
In a study employing a rodent model of sepsis – cecal ligation and puncture (CLP) – a relationship was observed between the induction of SOCS and both the presence of sepsis and the administration of PN [14].
CLP Binding (ligation) of in puncture associated with sepsis
8) Confidence 0.04 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.43 Pain Relevance 0.29
Polymicrobial sepsis was induced in adult male rats by cecal ligation and puncture (CLP).
CLP Binding (ligation) of in CLP associated with sepsis
9) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677660 Disease Relevance 0.64 Pain Relevance 0.15
CIS = cytokine-inducible SH2-containing protein; CLP = cecal ligation and puncture; CT = cycle threshold; E = PCR efficiency; EN = enteral nutrition; GH = growth hormone; GHR = growth hormone receptor; IGF-I = insulin-like growth factor-1; IGFBP-I = insulin-like growth factor binding protein-1; IL = interleukin; MNE = mean normalized expression; PCR = polymerase chain reaction; PN = parenteral nutrition; RT = reverse transcriptase; SOCS = suppressors of cytokine signaling; TNF = tumor necrosis factor.


CLP Binding (ligation) of in puncture associated with necrosis, cancer and cytokine
10) Confidence 0.03 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.69 Pain Relevance 0.21
PN was associated with the lowest serum IGFBP-I levels in both the CLP and sham-operated groups.
CLP Binding (associated) of
11) Confidence 0.03 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.29 Pain Relevance 0.28
Male Sprague–Dawley rats were randomized to laparotomy (Sham) or to cecal ligation and puncture (CLP), with postoperative saline infusion (Starve), with EN or with PN for 72 hours.
CLP Binding (ligation) of in CLP
12) Confidence 0.03 Published 2007 Journal Crit Care Section Abstract Doc Link PMC2206515 Disease Relevance 0.31 Pain Relevance 0.24

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