INT119212

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Context Info
Confidence 0.22
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.24
Pain Relevance 4.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nrg2) plasma membrane (Nrg2) embryo development (Nrg2)
Anatomy Link Frequency
shell 2
neuronal 1
aorta 1
Nrg2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 15 100.00 Very High Very High Very High
dopamine receptor 6 100.00 Very High Very High Very High
Morphine 27 99.84 Very High Very High Very High
Clonidine 15 99.80 Very High Very High Very High
Nucleus accumbens 21 98.64 Very High Very High Very High
Dopamine 3 78.44 Quite High
opiate 3 74.84 Quite High
agonist 1 41.16 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 3 99.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the absence of phenylephrine and prazosin, clonidine can also activate alpha1-adrenoceptors and rat aorta contraction.
Positive_regulation (activate) of alpha1 in aorta associated with clonidine
1) Confidence 0.22 Published 2004 Journal Vascul. Pharmacol. Section Abstract Doc Link 15664881 Disease Relevance 0 Pain Relevance 0.82
In the core, neuronal apoptotic inhibitory protein (NAIP), GABA-A alpha1 subunit, GRIN2C, GRIA1, mGluR1, D4 dopamine receptor and PSD-95 were upregulated by morphine administration whereas bax, bcl-x, cox-1 and MAP2 were decreased.
Positive_regulation (upregulated) of alpha1 in neuronal associated with gaba, dopamine receptor, apoptosis and morphine
2) Confidence 0.04 Published 2004 Journal Neuroscience Section Abstract Doc Link 15183518 Disease Relevance 0.10 Pain Relevance 1.38
Comparison of gene expression between the shell and core subregions of vehicle-treated rats revealed significantly higher relative abundance of GABA-A alpha1, Galphai2 and post-synaptic density protein 95 transcript (PSD-95) mRNA levels in the shell, whereas Ggamma2 and synuclein 1 were more abundant in the core of the NAc.
Positive_regulation (abundance) of alpha1 in shell associated with nucleus accumbens and gaba
3) Confidence 0.03 Published 2004 Journal Neuroscience Section Abstract Doc Link 15183518 Disease Relevance 0.06 Pain Relevance 0.85
Specifically, GABA-A alpha1 subunit, GRIA1 subunit and PSD-95 mRNAs were decreased in the shell but increased in the core following morphine administration.
Positive_regulation (increased) of alpha1 in shell associated with gaba and morphine
4) Confidence 0.03 Published 2004 Journal Neuroscience Section Abstract Doc Link 15183518 Disease Relevance 0.09 Pain Relevance 1.24

General Comments

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