INT119218

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Context Info
Confidence 0.58
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.11
Pain Relevance 3.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Fgfr1) cytoplasmic membrane-bounded vesicle (Fgfr1) plasma membrane (Fgfr1)
nucleus (Fgfr1) cytoplasm (Fgfr1)
Anatomy Link Frequency
NAc 2
neurons 1
Fgfr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 10 100.00 Very High Very High Very High
dorsal root ganglion 7 99.80 Very High Very High Very High
Morphine 18 99.68 Very High Very High Very High
Nucleus accumbens 14 99.36 Very High Very High Very High
Neuropathic pain 2 98.52 Very High Very High Very High
Sciatic nerve 3 94.84 High High
dopamine receptor 4 93.60 High High
Pain 1 92.96 High High
intrathecal 1 86.84 High High
unmyelinated 1 82.08 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 7 99.80 Very High Very High Very High
Neuropathic Pain 2 98.52 Very High Very High Very High
Pain 1 92.96 High High
Apoptosis 2 80.08 Quite High
Injury 1 76.36 Quite High
Nervous System Injury 1 62.04 Quite High
Neuritis 2 5.00 Very Low Very Low Very Low
Post-traumatic Stress Disorder 2 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the injured small DRG neurons, activation of FGFR1 may contribute to the generation of neuropathic pain by activating p38 MAPK.
Positive_regulation (activation) of FGFR1 in neurons associated with dorsal root ganglion and neuropathic pain
1) Confidence 0.58 Published 2007 Journal Neuroscience Section Abstract Doc Link 17905520 Disease Relevance 0.95 Pain Relevance 0.77
In the NAc shell, morphine administration resulted in upregulation of caspace 9, NF-kappaB, NF-H, tau, GABA-A delta subunit, FGFR1, Ggamma2, synuclein 1, syntaxin 5 and 13, GRK5, and c-fos mRNAs.
Positive_regulation (resulted) of FGFR1 in NAc associated with nucleus accumbens, gaba and morphine
2) Confidence 0.45 Published 2004 Journal Neuroscience Section Abstract Doc Link 15183518 Disease Relevance 0.08 Pain Relevance 1.14
As shown by these plots, by increasing the electrode density a stable MFR and MBR is reached especially for experiments 2, 3 and 7.
Positive_regulation (increasing) of MFR
3) Confidence 0.31 Published 2010 Journal Frontiers in Neuroengineering Section Body Doc Link PMC2871691 Disease Relevance 0 Pain Relevance 0
As shown by these plots, by increasing the electrode density a stable MFR and MBR is reached especially for experiments 2, 3 and 7.
Positive_regulation (stable) of MFR
4) Confidence 0.31 Published 2010 Journal Frontiers in Neuroengineering Section Body Doc Link PMC2871691 Disease Relevance 0 Pain Relevance 0
In the NAc shell, morphine administration resulted in upregulation of caspace 9, NF-kappaB, NF-H, tau, GABA-A delta subunit, FGFR1, Ggamma2, synuclein 1, syntaxin 5 and 13, GRK5, and c-fos mRNAs.
Positive_regulation (upregulation) of FGFR1 in NAc associated with nucleus accumbens, gaba and morphine
5) Confidence 0.30 Published 2004 Journal Neuroscience Section Abstract Doc Link 15183518 Disease Relevance 0.08 Pain Relevance 1.14

General Comments

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