INT119219

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Context Info
Confidence 0.64
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.16
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dlg4) protein complex assembly (Dlg4) response to stress (Dlg4)
cytoplasm (Dlg4)
Anatomy Link Frequency
shell 1
shafts 1
Dlg4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 5 99.26 Very High Very High Very High
Morphine 9 98.00 Very High Very High Very High
Nucleus accumbens 7 97.28 Very High Very High Very High
Hippocampus 25 90.64 High High
dopamine receptor 2 89.16 High High
long-term potentiation 9 83.72 Quite High
Action potential 5 79.76 Quite High
Dopamine 1 40.52 Quite Low
opiate 1 36.92 Quite Low
imagery 20 29.84 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 1 85.40 High High
Shock 4 72.32 Quite High
Amnesia 3 5.00 Very Low Very Low Very Low
Anxiety Disorder 2 5.00 Very Low Very Low Very Low
Pathologic Processes 2 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low
Nervous System Malformation 1 5.00 Very Low Very Low Very Low
Aging 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In practically all experiments, we observed a gradual increase in the total number of PSD-95:GFP puncta, mainly (but not exclusively) due to increased density of PSD-95:GFP puncta along existing dendritic segments, at both spine tips and shafts (Figures 1C and 3B).
Localization (number) of PSD-95 in shafts
1) Confidence 0.64 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2693930 Disease Relevance 0 Pain Relevance 0.10
Specifically, GABA-A alpha1 subunit, GRIA1 subunit and PSD-95 mRNAs were decreased in the shell but increased in the core following morphine administration.
Localization (decreased) of PSD-95 in shell associated with gaba and morphine
2) Confidence 0.35 Published 2004 Journal Neuroscience Section Abstract Doc Link 15183518 Disease Relevance 0.09 Pain Relevance 1.22
Our findings are consistent with others showing that, in vitro, BDNF upregulates local translation of PSD95 through mTOR pathway [76] and enhances the expression of GluR1 subunit of AMPA receptors via activation of mTOR [48].
Localization (translation) of PSD95
3) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0.07 Pain Relevance 0.18

General Comments

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