INT119227

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Context Info
Confidence 0.68
First Reported 2004
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 8
Total Number 17
Disease Relevance 10.67
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Tsc2) signal transduction (Tsc2) Golgi apparatus (Tsc2)
nucleus (Tsc2) intracellular (Tsc2) protein complex (Tsc2)
Anatomy Link Frequency
kidney 2
renal cortex 1
neurons 1
Tsc2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 6 63.76 Quite High
anesthesia 7 45.68 Quite Low
Angina 10 32.24 Quite Low
cerebral cortex 10 5.00 Very Low Very Low Very Low
transdermal 10 5.00 Very Low Very Low Very Low
adenocard 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 210 100.00 Very High Very High Very High
Targeted Disruption 36 99.98 Very High Very High Very High
Cancer 206 99.68 Very High Very High Very High
Autosomal Dominant Polycystic Kidney 10 99.68 Very High Very High Very High
Renal Disease 22 99.50 Very High Very High Very High
Hamartoma 84 98.92 Very High Very High Very High
Diabetes Mellitus 234 98.20 Very High Very High Very High
Renal Cancer 30 97.84 Very High Very High Very High
Anaplastic Astrocytoma 61 95.60 Very High Very High Very High
Angiomyolipoma 120 93.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both normal-appearing and dysmorphic neurons, as well as cells in the hamartomas, exhibited immunopositivity for tuberin, the protein product of the TSC2 gene.
Gene_expression (product) of TSC2 in neurons associated with hamartoma
1) Confidence 0.68 Published 2004 Journal Acta Neuropathol. Section Abstract Doc Link 15185103 Disease Relevance 1.04 Pain Relevance 0
The TSC genes TSC1 and TSC2 were first identified by positional cloning strategies.
Gene_expression (identified) of TSC2
2) Confidence 0.63 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.37 Pain Relevance 0
Allelic loss and intragenic mutation have been demonstrated in tumours in the Eker rat [105] and transgenic expression of TSC2 in the Eker rat and Eker tumour cell lines support its tumour-suppressor function [100].


Gene_expression (expression) of TSC2 associated with targeted disruption and cancer
3) Confidence 0.63 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 1.76 Pain Relevance 0
Following the identification of TSC1 and TSC2 as genes associated with human disease, murine models lacking TSC1 or TSC2 were generated by gene targeting [102].
Neg (lacking) Gene_expression (lacking) of TSC2 associated with disease
4) Confidence 0.55 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 1.04 Pain Relevance 0
Correspondingly, TSC1 disease is milder than TSC2 disease in multiple respects, which appears to be due to a reduced rate of second hit events [19-21].
Gene_expression (disease) of TSC2 associated with disease
5) Confidence 0.55 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.50 Pain Relevance 0
genotype and the severity of renal disease in TSC patients who had TSC2 mutations; they found an association between IFN-?
Gene_expression (mutations) of TSC2 associated with renal disease
6) Confidence 0.55 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.82 Pain Relevance 0
A possible explanation for this severe phenotype is a functional link between the TSC2 protein and polycystin-1 in protein sorting as described by Kleymenova et al. [57].
Gene_expression (protein) of TSC2
7) Confidence 0.55 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.56 Pain Relevance 0
Following the identification of TSC1 and TSC2 as genes associated with human disease, murine models lacking TSC1 or TSC2 were generated by gene targeting [102].
Neg (lacking) Gene_expression (lacking) of TSC2 associated with disease
8) Confidence 0.55 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 1.03 Pain Relevance 0
Structure of Hamartin (TSC1) and Tuberin (TSC2)
Gene_expression (Structure) of TSC2
9) Confidence 0.55 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.39 Pain Relevance 0
For many years, the prevailing model has been that the hamartomas of TSC develop through a two-hit mechanism in which there is complete loss of expression of functional TSC1 or TSC2, supported by findings of loss of heterozygosity (LOH) in TSC tumour samples [23-26].
Gene_expression (expression) of TSC2 associated with cancer and hamartoma
10) Confidence 0.49 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.44 Pain Relevance 0
The decrease in tuberin protein expression is associated with a decrease in OGG1 expression (20).
Gene_expression (expression) of tuberin
11) Confidence 0.33 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.18 Pain Relevance 0
OGG1 expression in the kidney of rats heterozygotes for tuberin is lower than that in wild-type rats (20).
Gene_expression (expression) of tuberin in kidney
12) Confidence 0.33 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.58 Pain Relevance 0
To confirm the validity of these data obtained in the MCT immortalized cells, we studied the effects of high glucose on the phosphorylation of Akt and tuberin and on OGG1 protein expression in RPTE cells.
Gene_expression (expression) of tuberin
13) Confidence 0.29 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0 Pain Relevance 0
RESULTS—In the renal cortex of diabetic rats, the increase in Akt phosphorylation is associated with enhanced phosphorylation of tuberin, decreased OGG1 protein expression, and 8-oxodG accumulation.
Gene_expression (expression) of tuberin in renal cortex associated with diabetes mellitus
14) Confidence 0.29 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2551671 Disease Relevance 0.34 Pain Relevance 0
We have recently shown that OGG1 is regulated by tuberin, the product of the tumor suppressor gene, TSC-2 (21).
Gene_expression (product) of tuberin associated with cancer
15) Confidence 0.29 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.56 Pain Relevance 0.03
Major genes for TSC and autosomal dominant polycystic kidney disease (PKD), TSC2 and PKD1, respectively, lie adjacent to each other at chromosome 16p3.3, suggesting a role for PKD1 in the etiology of renal cystic disease in TSC.
Gene_expression (respectively) of TSC2 in kidney associated with autosomal dominant polycystic kidney and disease
16) Confidence 0.24 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.63 Pain Relevance 0
The antioxidant N-acetylcysteine significantly inhibited ROS generation, Akt/protein kinase B, and tuberin phosphorylation and resulted in deceased 8-oxodG accumulation and upregulation of OGG1 protein expression.
Gene_expression (generation) of tuberin
17) Confidence 0.13 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2551671 Disease Relevance 0.44 Pain Relevance 0

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