INT119229

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Context Info
Confidence 0.24
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.80
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Eln) extracellular region (Eln) proteinaceous extracellular matrix (Eln)
extracellular matrix organization (Eln)
Anatomy Link Frequency
vasculature 2
Eln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 16 99.86 Very High Very High Very High
metalloproteinase 1 99.02 Very High Very High Very High
positron emission tomography 4 80.08 Quite High
cva 1 75.00 Quite High
Pain 1 48.72 Quite Low
imagery 1 25.00 Low Low
corticosteroid 4 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
chest pain 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 17 99.86 Very High Very High Very High
Alpha-1-antitrypsin Deficiency 12 98.50 Very High Very High Very High
Rupture 4 96.60 Very High Very High Very High
Abdominal Aortic Aneurysm 5 94.48 High High
Atherosclerosis 2 83.28 Quite High
Pulmonary Disease 28 82.36 Quite High
Emphysema 5 81.76 Quite High
Lung Injury 1 74.92 Quite High
Cardiovascular Disease 6 56.12 Quite High
Aneurism 3 47.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because chronic metalloproteinases production and activation by inflammatory cells causes degradation of elastin and collagen in the aneurysmal wall, the detection of an increased metabolic process preceding fissuration and rupture could be a more sensitive predictor of rupture risk.
Positive_regulation (causes) of Protein_catabolism (degradation) of elastin associated with inflammation, rupture and metalloproteinase
1) Confidence 0.24 Published 2004 Journal Semin Vasc Surg Section Abstract Doc Link 15185180 Disease Relevance 0.79 Pain Relevance 0.22
Low levels of A1AT, leading to unopposed neutrophil elastase activity in the vasculature may result in the local degradation of elastin, with a resultant increased collagen deposition.
Spec (may) Positive_regulation (result) of Protein_catabolism (degradation) of elastin in vasculature associated with alpha-1-antitrypsin deficiency
2) Confidence 0.01 Published 2010 Journal Respir Res Section Body Doc Link PMC3004850 Disease Relevance 1.01 Pain Relevance 0.10

General Comments

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