INT119230

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Context Info
Confidence 0.42
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.99
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Htt) endoplasmic reticulum (Htt) mitochondrion organization (Htt)
embryo development (Htt) protein complex (Htt) cytoplasm (Htt)
Anatomy Link Frequency
neurons 2
Htt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
headache 5 95.76 Very High Very High Very High
backache 1 90.40 High High
Analgesic 1 78.88 Quite High
cINOD 1 77.92 Quite High
Antihistamine 1 77.28 Quite High
corticosteroid 1 74.08 Quite High
projection neuron 2 42.40 Quite Low
imagery 12 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 121 100.00 Very High Very High Very High
Headache 4 95.76 Very High Very High Very High
Myalgia 1 94.96 High High
Erythema 1 94.52 High High
Increased Venous Pressure Under Development 1 94.24 High High
Staphylococcus Infection 1 93.96 High High
Fever 1 93.68 High High
Vomiting 2 93.12 High High
Discoid Lupus Erythematosus 1 92.84 High High
Systemic Sclerosis 1 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: While the pathophysiology of HDH is unknown, to diagnose patients with HDH or other possible HD-related headaches remains a challenge.


Negative_regulation (pathophysiology) of HDH
1) Confidence 0.42 Published 2009 Journal Arq Neuropsiquiatr Section Body Doc Link 20069204 Disease Relevance 0.06 Pain Relevance 0
Furthermore, knockdown of Htt by shRNA resulted in loss of the immunoreactive band, and reduced immunostaining of Htt in cortical neurons [10].
Negative_regulation (knockdown) of Htt in neurons
2) Confidence 0.41 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0.15 Pain Relevance 0
In previous studies, the loss of DARPP32 phenotype in our HD rat model has been correlated with loss of the neuronal marker NeuN, suggesting that it represents severe dysfunction and/or disappearance of striatal neurons and not only transcriptional alterations [11].
Negative_regulation (loss) of HD in neurons associated with disease
3) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645678 Disease Relevance 0.10 Pain Relevance 0
-Gal and mutant Htt is significantly reduced in aged rats.
Negative_regulation (reduced) of mutant Htt
4) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645678 Disease Relevance 0.72 Pain Relevance 0
In most cases, hdIVIg is effective only in combination with other immunomodulating strategies and allows for the reduction of adjuvants.
Negative_regulation (reduction) of hdIVIg
5) Confidence 0.08 Published 2004 Journal Am J Clin Dermatol Section Abstract Doc Link 15186194 Disease Relevance 1.96 Pain Relevance 0.50

General Comments

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