INT119233

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Context Info
Confidence 0.70
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 65
Total Number 66
Disease Relevance 20.21
Pain Relevance 17.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpv4) plasma membrane (Trpv4) cilium (Trpv4)
transmembrane transport (Trpv4)
Anatomy Link Frequency
neurons 4
bladders 2
skin 2
primary neurons 1
aorta 1
Trpv4 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 672 99.84 Very High Very High Very High
Kinase C 128 99.76 Very High Very High Very High
spinal dorsal horn 228 99.68 Very High Very High Very High
Inflammation 261 99.64 Very High Very High Very High
substance P 46 99.48 Very High Very High Very High
Pain 1005 99.32 Very High Very High Very High
agonist 449 99.26 Very High Very High Very High
Neuropathic pain 105 98.96 Very High Very High Very High
Spinal cord 168 98.88 Very High Very High Very High
calcitonin gene related peptide 36 98.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 692 99.84 Very High Very High Very High
Nociception 316 99.72 Very High Very High Very High
INFLAMMATION 252 99.64 Very High Very High Very High
Pain 1034 99.32 Very High Very High Very High
Stress 139 99.16 Very High Very High Very High
Targeted Disruption 394 99.04 Very High Very High Very High
Neuropathic Pain 247 98.96 Very High Very High Very High
Neurogenic Inflammation 31 98.84 Very High Very High Very High
Dyspepsia 12 98.52 Very High Very High Very High
Pressure And Volume Under Development 94 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transient receptor potential vanilloid 4 (TRPV4), a cation channel responsive to hypotonicity, can also be activated by warm temperatures.
Positive_regulation (activated) of TRPV4
1) Confidence 0.70 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15689568 Disease Relevance 0.35 Pain Relevance 0.18
Transient receptor potential vanilloid 4 (TRPV4), a cation channel responsive to hypotonicity, can also be activated by warm temperatures.
Positive_regulation (activated) of vanilloid 4
2) Confidence 0.70 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15689568 Disease Relevance 0.35 Pain Relevance 0.18
Another related compound, andrographolide, found in abundance in the plant Andrographis was unable to activate or block activation of TRPV4 channels.
Positive_regulation (activation) of TRPV4
3) Confidence 0.69 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16899456 Disease Relevance 0 Pain Relevance 0.11
An extract from the plant Andrographis paniculata potently activated TRPV4 channels.
Positive_regulation (activated) of TRPV4
4) Confidence 0.69 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16899456 Disease Relevance 0 Pain Relevance 0.18
This compound also activated TRPV4 currents in cell-free outside-out patches from HEK293T cells overexpressing TRPV4 cDNA, suggesting that BAA can activate the channel in a membrane-delimited manner.
Positive_regulation (activated) of TRPV4
5) Confidence 0.69 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16899456 Disease Relevance 0 Pain Relevance 0.14
Bisandrographolide from Andrographis paniculata activates TRPV4 channels.
Positive_regulation (activates) of TRPV4
6) Confidence 0.69 Published 2006 Journal J. Biol. Chem. Section Title Doc Link 16899456 Disease Relevance 0 Pain Relevance 0.18
Alternatively, TRPV4 can be activated by diverse chemical stimuli such as the synthetic phorbol ester 4?
Positive_regulation (activated) of TRPV4
7) Confidence 0.69 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948364 Disease Relevance 0.34 Pain Relevance 0.10
TRPV4 is activated by a variety of stimuli, including hypotonicity-induced cell swelling, which is akin to a mechanical stimulus (Liedtke et al., 2000; Nilius et al., 2001, 2004).
Positive_regulation (activated) of TRPV4 associated with pressure and volume under development
8) Confidence 0.68 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.28 Pain Relevance 0.06
Hypotonicity-induced activation of TRPV4 requires its interaction with the water channel aquaporin (AQP) 5 [9].
Positive_regulation (activation) of TRPV4
9) Confidence 0.64 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0.09 Pain Relevance 0.11
Temperature thresholds for activation of TRPV1, TRPV4, and TRPM8 are not fixed but changeable.
Positive_regulation (activation) of TRPV4
10) Confidence 0.63 Published 2004 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 15467255 Disease Relevance 0.26 Pain Relevance 0.20
Rat embryonic cultured hippocampal neurons were used to study the modulation of synaptic transmission by activation of TRPV4.
Positive_regulation (activation) of TRPV4 in neurons
11) Confidence 0.59 Published 2009 Journal Mol Pain Section Body Doc Link PMC2650694 Disease Relevance 0.07 Pain Relevance 0.24
The activation of TRPV4 facilitated substance P (SP) and calcitonin gene related peptide (CGRP) release from the central terminals of primary neurons in the spinal cord [30].
Positive_regulation (activation) of TRPV4 in primary neurons associated with calcitonin gene related peptide, spinal cord and substance p
12) Confidence 0.59 Published 2009 Journal Mol Pain Section Body Doc Link PMC2650694 Disease Relevance 0.65 Pain Relevance 0.60
Although PDBu can modulate synaptic transmission by itself, we observed that activation of TRPV4 and PKC, synergistically increased the frequency of mEPSCs as shown with TRPV1 [25].
Positive_regulation (activation) of TRPV4
13) Confidence 0.59 Published 2009 Journal Mol Pain Section Body Doc Link PMC2650694 Disease Relevance 0.28 Pain Relevance 0.44
These experiments show that BAA activates TRPV4 channels, and we discuss the possibility that activation of TRPV4 by BAA could play a role in some of the effects of Andrographis extract described in traditional medicine.
Positive_regulation (activation) of TRPV4
14) Confidence 0.50 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16899456 Disease Relevance 0 Pain Relevance 0.05
By using a novel TRPV4 channel activator (GSK1016790A) (Figure 1) that is about 300-fold more potent than the commonly used TRPV4 activator 4?
Positive_regulation (used) of TRPV4
15) Confidence 0.50 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948364 Disease Relevance 0.37 Pain Relevance 0.34
By using a novel TRPV4 channel activator (GSK1016790A) (Figure 1) that is about 300-fold more potent than the commonly used TRPV4 activator 4?
Positive_regulation (activator) of TRPV4
16) Confidence 0.50 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948364 Disease Relevance 0.37 Pain Relevance 0.34
Furthermore, the authors confirmed that in vitro mechanical stretch stimulation of urothelial cells activated TRPV4, leading to increased [Ca2+]i and ATP release.
Positive_regulation (activated) of TRPV4 in urothelial cells
17) Confidence 0.50 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948364 Disease Relevance 0.05 Pain Relevance 0.33
We report a major role for TRPV4, which detects osmotic pressure and arachidonic acid metabolites, and TRPA1, which responds to 4-hydroxynonenal and cyclopentenone prostaglandins, in pancreatic inflammation and pain in mice.
Positive_regulation (role) of TRPV4 associated with pain and inflammation
18) Confidence 0.50 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20539005 Disease Relevance 0.82 Pain Relevance 0.66
Transient receptor potential vanilloid 4 (TRPV4) is a cation channel activated at a warm temperature (over 30 degrees C) in exogenously expressed cells.
Positive_regulation (activated) of TRPV4
19) Confidence 0.47 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15187078 Disease Relevance 0.22 Pain Relevance 0.22
Transient receptor potential vanilloid 4 (TRPV4) is a cation channel activated at a warm temperature (over 30 degrees C) in exogenously expressed cells.
Positive_regulation (activated) of vanilloid 4
20) Confidence 0.47 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15187078 Disease Relevance 0.22 Pain Relevance 0.22

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