INT119238

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Context Info
Confidence 0.40
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.14
Pain Relevance 3.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcb1a) ATPase activity (Abcb1a) plasma membrane (Abcb1a)
transmembrane transport (Abcb1a)
Anatomy Link Frequency
brain 4
Caco-2 2
Abcb1a (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 9 100.00 Very High Very High Very High
Cannabinoid 8 99.84 Very High Very High Very High
fortral 11 99.72 Very High Very High Very High
qutenza 11 99.58 Very High Very High Very High
Antinociceptive 2 96.44 Very High Very High Very High
nMDA receptor antagonist 1 94.32 High High
tolerance 6 91.60 High High
tail-flick 1 84.56 Quite High
Analgesic 3 81.84 Quite High
agonist 1 73.36 Quite High
Disease Link Frequency Relevance Heat
Skin Cancer 16 97.96 Very High Very High Very High
Cancer 41 97.60 Very High Very High Very High
Osteogenic Sarcomas 1 94.24 High High
Plasmacytoma 2 93.56 High High
Metastasis 4 80.60 Quite High
Leukemia 1 79.36 Quite High
Shock 10 50.00 Quite Low
Appetite Loss 1 48.28 Quite Low
Disease 1 47.88 Quite Low
Vomiting 1 47.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, longer term (48 and 72 h) co-incubation of the Caco-2 cells with capsaicin (50 and 100 microM) increased P-gp activity through an up-regulation of cellular P-gp protein and MDR1 mRNA levels.
Positive_regulation (increased) of Positive_regulation (increased) of P-gp protein in Caco-2 associated with qutenza
1) Confidence 0.40 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16674925 Disease Relevance 0 Pain Relevance 0.72
A high dose of oxymatrine (30 mg/kg) also significantly inhibited the dramatic increase in expression of morphine-induced P-glycoprotein (P-gp), an ATP-dependent efflux pump acting at the blood-brain barrier, by Western blot analysis.
Positive_regulation (increase) of Positive_regulation (induced) of P-gp in brain associated with morphine
2) Confidence 0.14 Published 2010 Journal Integr Cancer Ther Section Abstract Doc Link 20587445 Disease Relevance 0 Pain Relevance 1.21
Taken together, these results provide preliminary evidence that cannabinoids do not exacerbate P-gp mediated MDR.
Neg (not) Positive_regulation (exacerbate) of Neg (not) Positive_regulation (mediated) of P-gp associated with cannabinoid
3) Confidence 0.12 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16458258 Disease Relevance 0.20 Pain Relevance 0.32
The apparent uptake of PTZ by the brain increased in the presence of P-gp inhibitors such as cyclosporin A, quinidine, verapamil and vinblastine after the carotid injection.
Positive_regulation (increased) of Positive_regulation (presence) of P-gp in brain associated with fortral
4) Confidence 0.06 Published 2004 Journal Biol. Pharm. Bull. Section Abstract Doc Link 15187451 Disease Relevance 0 Pain Relevance 0.85
In contrast, Schadendorf et al. [17] did not find an enhanced induction of p-gp in vindesine- and cisplatin-pretreated metastasic melanoma.
Positive_regulation (enhanced) of Positive_regulation (induction) of p-gp associated with skin cancer
5) Confidence 0.02 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2903950 Disease Relevance 0.95 Pain Relevance 0

General Comments

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