INT119268

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Context Info
Confidence 0.21
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.44
Pain Relevance 0.07

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nucleoplasm (CDKN1A, CREBBP) cytoplasm (CDKN1A, CREBBP) nucleus (CDKN1A, CREBBP)
small molecule metabolic process (CREBBP) protein complex assembly (CREBBP) DNA binding (CREBBP)
CDKN1A (Homo sapiens)
CREBBP (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Aging 1 97.66 Very High Very High Very High
Stress 1 96.98 Very High Very High Very High
Disease 2 93.08 High High
Cytomegalovirus Infection 1 77.52 Quite High
INFLAMMATION 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
p21(Waf1/Cip1/Sdi1) is the primary mediator of cell cycle arrest in response to different forms of stress and in the programs of senescence and differentiation. p21 interacts with many regulatory proteins and has broad effects on cellular gene expression. p21 was previously shown to stimulate NFkappaB transcriptional activity through its effect on the p300/CBP transcription cofactor family. p21 expression in human cells increases mRNA levels of different genes, some of which have been implicated in carcinogenesis and age-related diseases.
p21 Regulation (effect) of CBP associated with stress, aging and disease
1) Confidence 0.21 Published 2004 Journal Cell Cycle Section Abstract Doc Link 15190207 Disease Relevance 0.44 Pain Relevance 0.07

General Comments

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