INT119269

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Context Info
Confidence 0.47
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 8.82
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CDKN1A) nucleoplasm (CDKN1A) nucleus (CDKN1A)
cell cycle (CDKN1A) kinase activity (CDKN1A) cytoplasm (CDKN1A)
Anatomy Link Frequency
plasma 1
HGF 1
tubules 1
CDKN1A (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 63 97.24 Very High Very High Very High
cINOD 3 75.00 Quite High
antagonist 27 66.60 Quite High
methotrexate 1 48.00 Quite Low
vincristine 1 46.88 Quite Low
Pain 9 37.00 Quite Low
Inflammation 37 36.64 Quite Low
narcan 27 19.84 Low Low
Opioid 39 11.00 Low Low
cerebral cortex 36 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 524 100.00 Very High Very High Very High
Stress 7 99.68 Very High Very High Very High
Aging 5 99.56 Very High Very High Very High
Cancer 196 99.52 Very High Very High Very High
Cyst 42 99.40 Very High Very High Very High
Glioblastoma 47 98.76 Very High Very High Very High
Death 91 94.96 High High
Retinoblastoma 84 94.08 High High
Pancreatic Cancer 105 88.64 High High
Anaplastic Astrocytoma 2 85.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, we speculated that the resulting increased p21Cip1 and p27Kip1, by binding to and consequently inhibiting the cyclin E/CDK2 complex activity, potentiated the cell cycle arrest in G0/G1 phase, as also reported by others [28].
p21Cip1 Binding (binding) of
1) Confidence 0.47 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0 Pain Relevance 0
This reduction in Cdk2 kinase activity correlated with an increase in Cdk2/p21 complex formation in the OGF-exposed cells relative to control cultures at all time points.
p21 Binding (formation) of
2) Confidence 0.41 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.86 Pain Relevance 0
To further examine the mechanism by which cyst formation occurs by means of p21 attenuation, we utilized the growth factor HGF.
p21 Binding (attenuation) of in HGF associated with cyst
3) Confidence 0.36 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC2045080 Disease Relevance 0.83 Pain Relevance 0
We next asked whether attenuation of p21 in MDCK cells, which have the potential to form either cysts or tubules [23], results in enhanced cell cycle transit.
p21 Spec (whether) Binding (attenuation) of in tubules associated with cyst
4) Confidence 0.36 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC2045080 Disease Relevance 0.35 Pain Relevance 0
p21(Waf1/Cip1/Sdi1) is the primary mediator of cell cycle arrest in response to different forms of stress and in the programs of senescence and differentiation. p21 interacts with many regulatory proteins and has broad effects on cellular gene expression. p21 was previously shown to stimulate NFkappaB transcriptional activity through its effect on the p300/CBP transcription cofactor family. p21 expression in human cells increases mRNA levels of different genes, some of which have been implicated in carcinogenesis and age-related diseases.
p21 Binding (interacts) of associated with stress, aging and disease
5) Confidence 0.35 Published 2004 Journal Cell Cycle Section Abstract Doc Link 15190207 Disease Relevance 0.42 Pain Relevance 0.07
Since p21/Waf-1 may prevent apoptosis by interacting with PCNA [51], we examined the expression of p21/Waf-1 in dissociated embryonic cortical cells that were exposed to sFasL, estrogen or both sFasL and estrogen for 12 hours.
Waf-1 Binding (interacting) of associated with apoptosis
6) Confidence 0.35 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.50 Pain Relevance 0
Although an association with p21WAF1/CIP1 protein accumulation has been reported [19], the exact mechanism of DXM mediated protection of glioblastoma cells from apoptosis is still largely unclarified.
CIP1 Binding (association) of associated with glioblastoma, apoptosis and dexamethasone
7) Confidence 0.35 Published 2004 Journal Mol Cancer Section Body Doc Link PMC544397 Disease Relevance 1.62 Pain Relevance 0.17
For example, PCNA and p21/Waf-1 bind to each other to prevent apoptosis induction [51], and to promote repair of double strand breaks in DNA, a characteristic of apoptosis.
Waf-1 Binding (bind) of associated with apoptosis
8) Confidence 0.35 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.53 Pain Relevance 0.03
For example, PCNA and p21/Waf-1 bind to each other to prevent apoptosis induction [51], and to promote repair of double strand breaks in DNA, a characteristic of apoptosis.
p21 Binding (bind) of associated with apoptosis
9) Confidence 0.35 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.53 Pain Relevance 0.03
Since p21/Waf-1 may prevent apoptosis by interacting with PCNA [51], we examined the expression of p21/Waf-1 in dissociated embryonic cortical cells that were exposed to sFasL, estrogen or both sFasL and estrogen for 12 hours.
p21 Binding (interacting) of associated with apoptosis
10) Confidence 0.35 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.50 Pain Relevance 0
Thus, OGF exerts its effects in these cancer cells by inducing Cdk2/p21 complexes.
p21 Binding (complexes) of associated with cancer
11) Confidence 0.32 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.80 Pain Relevance 0
p21 has been considered as a target for potential anticancer drugs [19,20].
p21 Binding (target) of
12) Confidence 0.31 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.81 Pain Relevance 0
Furthermore, in basal conditions, these mutants are as active as the wild-type protein in repressing DRE-dependent transcription and remain bound to DNA acting as dominant negative repressors following Ca2+ or cAMP stimulation (1,3,7).
wild-type protein Binding (bound) of
13) Confidence 0.31 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.12 Pain Relevance 0
The ras protein is known to undergo a series of post-translational modifications at the c-terminal CAAX motif, which forms a thioether bond of p21 ras with farnesyl and ties it to the plasma membrane [117].
p21 Binding (bond) of in plasma
14) Confidence 0.09 Published 2003 Journal Respir Res Section Body Doc Link PMC314397 Disease Relevance 0.46 Pain Relevance 0
CDK2 associates with cyclin E and during events of cell stress or DNA damage, p21 can bind the CDK2/cyclinE complex and induce cell cycle arrest at G1/S.
p21 Binding (bind) of associated with stress
15) Confidence 0.02 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2771360 Disease Relevance 0.48 Pain Relevance 0

General Comments

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