INT119324

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Context Info
Confidence 0.53
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.94
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (Ramp1) signal transduction (Ramp1) transport (Ramp1)
extracellular space (Ramp1) plasma membrane (Ramp1)
Anatomy Link Frequency
spinal cord 2
uterine 2
Ramp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 105 98.40 Very High Very High Very High
Spinal cord 5 97.92 Very High Very High Very High
calcitonin gene related peptide 1 92.32 High High
Nucleus accumbens 4 86.80 High High
nMDA receptor 19 79.48 Quite High
antagonist 5 74.16 Quite High
Inflammation 6 62.64 Quite High
Pain 51 56.20 Quite High
amygdala 87 50.84 Quite High
nMDA receptor antagonist 6 36.36 Quite Low
Disease Link Frequency Relevance Heat
Uterine Fibroids 72 98.56 Very High Very High Very High
Cancer 22 86.88 High High
Apoptosis 9 81.88 Quite High
INFLAMMATION 4 62.64 Quite High
Pain 50 56.20 Quite High
Nociception 4 16.24 Low Low
Rheumatoid Arthritis 23 5.00 Very Low Very Low Very Low
Injury 7 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of RAMP1 enhanced the pronociceptive effects of CGRP in the spinal cord [42].
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of RAMP1 in spinal cord associated with spinal cord and calcitonin gene-related peptide
1) Confidence 0.53 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829526 Disease Relevance 0.06 Pain Relevance 0.58
Coexpression of RAMP1 and CRLR resulted in functional CGRP1 receptors; the complex of RAMP2 or RAMP3 and CRLR created functional adrenomedullin receptor.
Positive_regulation (resulted) of Gene_expression (Coexpression) of RAMP1
2) Confidence 0.47 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15193773 Disease Relevance 0.06 Pain Relevance 0.26
Using a rat uterine fibroid-derived cell line (ELT3), Thota and Yallampalli [34] demonstrated that expression of CALCRL and RAMP1 increased with progesterone and decreased with estrogen, consistent with what Helvering et al found in the array work (Table 3).
Positive_regulation (increased) of Gene_expression (expression) of RAMP1 in uterine associated with uterine fibroids
3) Confidence 0.21 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.83 Pain Relevance 0.05

General Comments

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