INT119331

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Context Info
Confidence 0.60
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 0.19
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (Ramp2) signal transduction (Ramp2) plasma membrane (Ramp2)
cellular_component (Ramp2) cytoplasm (Ramp2)
Anatomy Link Frequency
nucleus accumbens 1
Ramp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 4 99.68 Very High Very High Very High
Inflammation 113 97.88 Very High Very High Very High
Pain 1 78.80 Quite High
Calcitonin gene-related peptide 70 75.00 Quite High
antagonist 156 73.28 Quite High
Nerve growth factor 112 5.00 Very Low Very Low Very Low
cytokine 88 5.00 Very Low Very Low Very Low
agonist 88 5.00 Very Low Very Low Very Low
substance P 64 5.00 Very Low Very Low Very Low
gABA 60 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 115 97.88 Very High Very High Very High
Stress 192 5.00 Very Low Very Low Very Low
Cancer 88 5.00 Very Low Very Low Very Low
Targeted Disruption 88 5.00 Very Low Very Low Very Low
Pituitary Cancer 44 5.00 Very Low Very Low Very Low
Starvation 40 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 32 5.00 Very Low Very Low Very Low
Natriuresis 28 5.00 Very Low Very Low Very Low
Adhesions 24 5.00 Very Low Very Low Very Low
Hyperplasia 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results demonstrate that CGRP, CRLR, RAMP1 and RAMP2 exist in the nucleus accumbens of intact rats, and that they were significantly upregulated in rats with inflammation.
Gene_expression (exist) of RAMP2 in nucleus accumbens associated with nucleus accumbens and inflammation
1) Confidence 0.60 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15193773 Disease Relevance 0.19 Pain Relevance 0.47
Increased RAMP-3 expression has been suggested to switch the cell from a state of high responsiveness to adrenomedullin (high RAMP-2 expression under basal conditions) to a blunted responsiveness.
Gene_expression (expression) of RAMP-2
2) Confidence 0.16 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.13
As discussed in the latter review, in most tissues under basal conditions, expression of RAMP-3 is relatively low and mainly RAMP-2 is expressed.
Gene_expression (expressed) of RAMP-2
3) Confidence 0.16 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.03
During pregnancy, the expression of RAMP-3 is strongly increased whereas RAMP-2 and CLR expression are depressed.
Gene_expression (expression) of RAMP-2
4) Confidence 0.16 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.09
As discussed in the latter review, in most tissues under basal conditions, expression of RAMP-3 is relatively low and mainly RAMP-2 is expressed.
Gene_expression (expression) of RAMP-2
5) Confidence 0.14 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.03

General Comments

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