INT11934

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Context Info
Confidence 0.44
First Reported 1990
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 1.72
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transporter activity (Sv2a) endoplasmic reticulum (Sv2a) cytoplasm (Sv2a)
Anatomy Link Frequency
blood 1
brain 1
vesicle 1
SV2A 1
heart 1
Sv2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
GABAergic 21 98.36 Very High Very High Very High
Action potential 1 97.56 Very High Very High Very High
Neurotransmitter 3 96.00 Very High Very High Very High
Central nervous system 4 95.40 Very High Very High Very High
Calcium channel 7 90.64 High High
anesthesia 3 88.20 High High
gABA 10 84.96 Quite High
Potency 2 84.96 Quite High
headache 7 83.44 Quite High
antiepileptic Drug 35 77.88 Quite High
Disease Link Frequency Relevance Heat
Critical Illness 2 99.04 Very High Very High Very High
Epilepsy 76 94.68 High High
Targeted Disruption 1 92.92 High High
Convulsion 147 92.00 High High
Liver Disease 1 88.72 High High
Reflex Epilepsy 1 84.36 Quite High
Asthenia 4 84.24 Quite High
Headache 7 83.44 Quite High
Dizziness 7 82.64 Quite High
Syndrome 13 81.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The exact role of the SV2A protein is not fully understood; it is thought to participate in the physiologic functioning of the synaptic vesicle.19 Its role in epilepsy is supported by the fact that SV2A knock-out mice develop seizures soon after birth and usually die within 3 weeks.21 Furthermore, the affinity of various compounds to the SV2A binding site correlates strongly with their anti-seizure potency in the audiogenic epilepsy mouse model.19


Regulation (role) of SV2A in SV2A associated with targeted disruption, epilepsy, convulsion, reflex epilepsy and potency
1) Confidence 0.44 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2747386 Disease Relevance 0.45 Pain Relevance 0.32
Because LEV does not appear to affect normal brain physiology, it is believed to modulate SV2A function only under pathophysiologic conditions (Lynch et al 2004).
Regulation (modulate) of SV2A in brain
2) Confidence 0.42 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2655081 Disease Relevance 0.57 Pain Relevance 0.17
The exact role of the SV2A protein is not fully understood, but it is thought to be involved in the regulation of vesicle exocytosis.45
Regulation (role) of SV2A in vesicle
3) Confidence 0.22 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2898169 Disease Relevance 0.44 Pain Relevance 0.35
The purpose of this multisite study was to determine the effects of endotracheal suctioning on mixed venous oxygen saturation (SvO2) and heart rate in 189 critically ill adults.
Spec (determine) Regulation (effects) of SvO2 in heart associated with critical illness
4) Confidence 0.15 Published 1990 Journal Heart Lung Section Abstract Doc Link 2211166 Disease Relevance 0.17 Pain Relevance 0.08
Therefore, a prospective study was performed to determine changes in SvO2 during OLT and to study the correlation between SvO2 and hemodynamic measurements.
Spec (determine) Regulation (changes) of SvO2
5) Confidence 0.08 Published 1992 Journal J. Cardiothorac. Vasc. Anesth. Section Abstract Doc Link 1610991 Disease Relevance 0.09 Pain Relevance 0.09
The results suggest that over the time course of the study, in vivo SvO2 values obtained with the two-wavelength catheter and the SAT-2 oximeter closely approximated SvO2 measured with a reference oximeter from mixed venous blood samples (r = 0.917; SEE 3.5%) in cardiac surgical patients in whom marked physiological changes occur.
Regulation (values) of SvO2 in blood
6) Confidence 0.00 Published 1992 Journal J. Cardiothorac. Vasc. Anesth. Section Abstract Doc Link 1610990 Disease Relevance 0 Pain Relevance 0.08

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