INT11936

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Context Info
Confidence 0.50
First Reported 1992
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 34
Total Number 35
Disease Relevance 26.85
Pain Relevance 10.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) extracellular region (Il6)
Anatomy Link Frequency
plasma 7
brain 5
liver 4
cavities 2
osteoclast 2
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 528 100.00 Very High Very High Very High
cytokine 436 100.00 Very High Very High Very High
chemokine 59 100.00 Very High Very High Very High
Inflammatory mediators 19 100.00 Very High Very High Very High
Hyperalgesia 29 99.92 Very High Very High Very High
spastic colon 4 99.84 Very High Very High Very High
Thermal hyperalgesia 5 99.76 Very High Very High Very High
Neuropathic pain 7 98.96 Very High Very High Very High
Brush evoked pain 6 98.76 Very High Very High Very High
vagus nerve 2 97.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 589 100.00 Very High Very High Very High
Cancer 103 100.00 Very High Very High Very High
Necrosis 24 100.00 Very High Very High Very High
Hyperalgesia 34 99.92 Very High Very High Very High
Functional Bowel Disorder 2 99.84 Very High Very High Very High
Obesity 296 99.80 Very High Very High Very High
Injury 84 99.60 Very High Very High Very High
Pulmonary Disease 41 99.20 Very High Very High Very High
Asthma 138 99.12 Very High Very High Very High
Stress 61 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This polymorphism influences the levels of circulating IL-6, suggesting a causal role for high circulating IL-6 levels in the pathogenesis of PH in patients with COPD.
Positive_regulation (influences) of Positive_regulation (circulating) of IL-6 associated with pulmonary disease and primary pulmonary hypertension
1) Confidence 0.50 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 1.58 Pain Relevance 0.31
This hyperalgesia is accompanied by a sustained upregulation of interleukin-1beta (IL-1beta) and an early upregulation of interleukin-6 (IL-6) which is restored to normal levels after five days of infection.
Positive_regulation (accompanied) of Positive_regulation (upregulation) of IL-6 associated with hyperalgesia and infection
2) Confidence 0.50 Published 2006 Journal Exp. Parasitol. Section Abstract Doc Link 16516198 Disease Relevance 1.47 Pain Relevance 0.74
This hyperalgesia is accompanied by a sustained upregulation of interleukin-1beta (IL-1beta) and an early upregulation of interleukin-6 (IL-6) which is restored to normal levels after five days of infection.
Positive_regulation (restored) of Positive_regulation (upregulation) of interleukin-6 associated with hyperalgesia and infection
3) Confidence 0.50 Published 2006 Journal Exp. Parasitol. Section Abstract Doc Link 16516198 Disease Relevance 1.44 Pain Relevance 0.72
This hyperalgesia is accompanied by a sustained upregulation of interleukin-1beta (IL-1beta) and an early upregulation of interleukin-6 (IL-6) which is restored to normal levels after five days of infection.
Positive_regulation (accompanied) of Positive_regulation (upregulation) of interleukin-6 associated with hyperalgesia and infection
4) Confidence 0.50 Published 2006 Journal Exp. Parasitol. Section Abstract Doc Link 16516198 Disease Relevance 1.47 Pain Relevance 0.74
This hyperalgesia is accompanied by a sustained upregulation of interleukin-1beta (IL-1beta) and an early upregulation of interleukin-6 (IL-6) which is restored to normal levels after five days of infection.
Positive_regulation (restored) of Positive_regulation (upregulation) of IL-6 associated with hyperalgesia and infection
5) Confidence 0.50 Published 2006 Journal Exp. Parasitol. Section Abstract Doc Link 16516198 Disease Relevance 1.44 Pain Relevance 0.72
Consistent with a direct effect of IL-6 on Nox2 expression, direct systemic injection of IL-6 into mice increased Nox2 protein and activity, confirming the ability of peripheral IL-6 to mediate increased Nox2 expression and superoxide production in brain.
Positive_regulation (increased) of Positive_regulation (injection) of IL-6 in brain
6) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.13 Pain Relevance 0.04
Both TNF and IL-6 induction was augmented by S-KPF, but anti-TNF antibodies abolished the augmentation of IL-6 production.
Positive_regulation (augmented) of Positive_regulation (induction) of IL-6
7) Confidence 0.47 Published 2000 Journal Cytokine Section Abstract Doc Link 10930297 Disease Relevance 0.09 Pain Relevance 0.13
By using the B9 cell bioassay, it was found that injection of pristane caused a marked and prolonged elevation of interleukin-6 (IL-6) levels in the peritoneal cavities of the mice.
Positive_regulation (caused) of Positive_regulation (elevation) of IL-6 in cavities
8) Confidence 0.47 Published 1992 Journal Blood Section Abstract Doc Link 1611085 Disease Relevance 0.32 Pain Relevance 0.13
An important finding from our study was that exposure to hypoxia was associated with a marked and early rise in IL-6 mRNA levels, which led to a more prolonged increase in IL-6 protein, lasting up to 7 days but followed by a return to basal levels by day 14.
Positive_regulation (led) of Positive_regulation (increase) of IL-6 protein associated with hypoxia
9) Confidence 0.47 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 1.38 Pain Relevance 0.22
Stress effects on the hypopituitary axis can also lead to local induction of IL-6 in brain and secondary release into blood, a potential additional source of IL-6 in both brain and plasma[3] (and references therein).
Positive_regulation (lead) of Positive_regulation (induction) of IL-6 in brain associated with stress
10) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.33 Pain Relevance 0.07
The increase in IL-6 and sIL-6R in SF increases the risk of joint destruction in RA [11].
Positive_regulation (increases) of Positive_regulation (increase) of IL-6 in joint associated with rheumatoid arthritis
11) Confidence 0.45 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 0.77 Pain Relevance 0.14
Based on these observations it appears that females were primed to respond to hepatic injury, as initially they generated higher levels of IL-6.
Positive_regulation (generated) of Positive_regulation (levels) of IL-6 associated with injury
12) Confidence 0.39 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1764413 Disease Relevance 0.69 Pain Relevance 0.15
PSL-induced upregulation of tumor necrosis factor-alpha and interleukin-6, which are essential for neuropathic pain, was suppressed by pioglitazone for the first week.
Positive_regulation (induced) of Positive_regulation (upregulation) of interleukin-6 associated with necrosis, cancer and neuropathic pain
13) Confidence 0.32 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19008646 Disease Relevance 1.55 Pain Relevance 1.56
The augmentation of IL-6 mRNA in mouse liver was markedly increased by paeoniflorin at 1 h and 3 h after LPS injection. 4.
Positive_regulation (increased) of Positive_regulation (augmentation) of IL-6 in liver
14) Confidence 0.26 Published 2006 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 16620297 Disease Relevance 0.82 Pain Relevance 0.05
Relevant to our model, Substance-P has been shown to participate in upregulation of inflammatory cytokines in fibroblastic cells[63], [64] and more recently in a model of increased IL-6, IL-1?
Positive_regulation (upregulation) of Positive_regulation (increased) of IL-6 associated with inflammation and cytokine
15) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0.91 Pain Relevance 0.26
To investigate the role of the Akt pathway in neurotrophin induction of IL-6, BMSC were pre-treated as described above with Akt VIII, a specific Akt inhibitor, for 2 hrs prior to stimulation with NGF or BDNF.
Spec (investigate) Positive_regulation (pathway) of Positive_regulation (induction) of IL-6
16) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0.13 Pain Relevance 0
To determine the optimal concentration of neurotrophins needed to induce NGF or BDNF signaling, resulting in IL-6 protein increase, a dose response curve was completed, using an IL-6 ELISA with doses of neurotrophins ranging from 0–100 ng/ml.
Positive_regulation (resulting) of Positive_regulation (increase) of IL-6 protein
17) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0.06 Pain Relevance 0
Second, we found increased IL-6 plasma levels upon both activated and inactivated hyaluronidase infusion.
Positive_regulation (inactivated) of Positive_regulation (increased) of IL-6 in plasma
18) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999536 Disease Relevance 0.33 Pain Relevance 0
This in turn causes an increase in hypothalamic IL-6, which raises the thermoregulatory set point.
Positive_regulation (causes) of Positive_regulation (increase) of IL-6
19) Confidence 0.19 Published 2003 Journal BMC Pediatr Section Body Doc Link PMC194752 Disease Relevance 1.19 Pain Relevance 0.48
Obese subjects have elevated inflammatory mediators, namely IL-6, IL-8, and TNF-?
Positive_regulation (elevated) of Positive_regulation (elevated) of IL-6 associated with inflammatory mediators and obesity
20) Confidence 0.18 Published 2010 Journal Int J Gen Med Section Body Doc Link PMC2990395 Disease Relevance 1.97 Pain Relevance 0.17

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