INT11937

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Context Info
Confidence 0.81
First Reported 1992
Last Reported 2011
Negated 2
Speculated 2
Reported most in Abstract
Documents 228
Total Number 231
Disease Relevance 139.83
Pain Relevance 64.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) extracellular region (Il6)
Anatomy Link Frequency
macrophages 14
T cells 9
monocytes 7
immune cells 6
adipocytes 6
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 3162 100.00 Very High Very High Very High
cytokine 3118 100.00 Very High Very High Very High
chemokine 410 100.00 Very High Very High Very High
Arthritis 296 100.00 Very High Very High Very High
Inflammatory mediators 265 100.00 Very High Very High Very High
anesthesia 80 99.98 Very High Very High Very High
depression 85 99.92 Very High Very High Very High
metalloproteinase 164 99.90 Very High Very High Very High
Morphine 492 99.82 Very High Very High Very High
rheumatoid arthritis 499 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 3810 100.00 Very High Very High Very High
Cancer 2923 100.00 Very High Very High Very High
Arthritis 348 100.00 Very High Very High Very High
Hypoxia 224 100.00 Very High Very High Very High
Insulin Resistance 207 100.00 Very High Very High Very High
Necrosis 203 100.00 Very High Very High Very High
Burns 28 100.00 Very High Very High Very High
Obesity 1340 99.98 Very High Very High Very High
Depression 87 99.92 Very High Very High Very High
Temporomandibular Joint Disorders 2 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Experiments performed in vitro showed that pristane-elicited macrophages secreted low levels of IL-6 constitutively and high levels of IL-6 in the presence of lipopolysaccharide.
Localization (secreted) of IL-6 in elicited macrophages
1) Confidence 0.81 Published 1992 Journal Blood Section Abstract Doc Link 1611085 Disease Relevance 0.47 Pain Relevance 0.20
Electrical stimulation substantially reduced IL-6 secretion at 6 h (control: 143.4 +/- 14.3 vs. electrical: 71.3 +/- 7.9 pg/ml/10(6) leukocytes, P = 0.0001).
Localization (secretion) of IL-6 in leukocytes
2) Confidence 0.81 Published 1995 Journal J. Neuroimmunol. Section Abstract Doc Link 7560012 Disease Relevance 0 Pain Relevance 0.17
As parameter for immune function, modulation of interleukin-6 (IL-6) release by the spleen cells brought about by electrical stimulation was investigated.
Localization (release) of IL-6 in spleen
3) Confidence 0.81 Published 1995 Journal J. Neuroimmunol. Section Abstract Doc Link 7560012 Disease Relevance 0 Pain Relevance 0.16
As parameter for immune function, modulation of interleukin-6 (IL-6) release by the spleen cells brought about by electrical stimulation was investigated.
Localization (release) of interleukin-6 in spleen
4) Confidence 0.81 Published 1995 Journal J. Neuroimmunol. Section Abstract Doc Link 7560012 Disease Relevance 0 Pain Relevance 0.16
We conclude from the complementary studies that the inhibition of IL-6 secretion induced by electrical pulses was mostly mediated by alpha-adrenergic and mu-opioidergic endogenous transmitters.
Localization (secretion) of IL-6
5) Confidence 0.80 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9084435 Disease Relevance 0 Pain Relevance 0.36
The endogenous opioids beta-endorphin (10(-10) M), methionine-enkephalin (10(-9) M), and leucine-enkephalin (10(-9) M) inhibited IL-6 secretion as well (p = 0.0051, p = 0.0337, and p = 0.0226, respectively).
Localization (secretion) of IL-6 associated with endogenous opioid and enkephalin
6) Confidence 0.80 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9084435 Disease Relevance 0 Pain Relevance 0.45
To study aspects of this neuronal-immune communication, a recently developed tissue slice method was used to study the effects of adrenergic and opioidergic transmitters on interleukin 6 (IL-6) secretion in the spleen.
Localization (secretion) of IL-6 in neuronal
7) Confidence 0.80 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9084435 Disease Relevance 0 Pain Relevance 0.30
Electrical stimulation of spleen slices inhibited IL-6 secretion (100.0 +/- 4.3 vs. 56.7 +/- 4.6% of control values; p < 0.001).
Localization (secretion) of IL-6 in spleen
8) Confidence 0.80 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9084435 Disease Relevance 0 Pain Relevance 0.44
The alpha 1-adrenergic agonist methoxamine (10(-8) M) also inhibited IL-6 secretion (100.0 +/- 4.8 vs. 71.5 +/- 3.8%; p < 0.001).
Localization (secretion) of IL-6 associated with agonist
9) Confidence 0.80 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9084435 Disease Relevance 0 Pain Relevance 0.43
Electrical inhibition of IL-6 secretion was attenuated by phentolamine (10(-7) M; p = 0.0345), by naloxone (10(-6) M; p = 0.0046), by cyprodime (10(-8) M; p = 0.0014), and by the combination of cyprodime (10(-7) M) plus phentolamine (10(-8) M; p < 0.0001).
Localization (secretion) of IL-6 associated with narcan
10) Confidence 0.80 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9084435 Disease Relevance 0 Pain Relevance 0.42
To study aspects of this neuronal-immune communication, a recently developed tissue slice method was used to study the effects of adrenergic and opioidergic transmitters on interleukin 6 (IL-6) secretion in the spleen.
Localization (secretion) of interleukin 6 in neuronal
11) Confidence 0.80 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9084435 Disease Relevance 0 Pain Relevance 0.30
Neuronal regulation of interleukin 6 secretion in murine spleen: adrenergic and opioidergic control.
Localization (secretion) of interleukin 6 in spleen associated with analgesic
12) Confidence 0.80 Published 1997 Journal J. Neurochem. Section Title Doc Link 9084435 Disease Relevance 0 Pain Relevance 0.60
The alpha 2-adrenergic agonist p-aminoclonidine (10(-7) M) inhibited IL-6 secretion (control vs. p-aminoclonidine, 100.0 +/- 4.76 vs. 59.3 +/- 6.6% of control values; p < 0.001).
Localization (secretion) of IL-6 associated with agonist
13) Confidence 0.80 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9084435 Disease Relevance 0 Pain Relevance 0.33
The P2X(1) agonist beta,gamma-methylene ATP inhibited IL-6 secretion at 10(-5) M, whereas the P2Y(1) agonist 2-methylthio ATP increased IL-6 secretion at 10(-6) to 10(-8) M.
Localization (secretion) of IL-6 associated with agonist
14) Confidence 0.79 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 11960643 Disease Relevance 0 Pain Relevance 0.75
In this study, we describe the role of exogenous and endogenous adenosine and exogenous P2X(1) and P2Y(1) agonists for spontaneous splenic IL-6 secretion from spleen slices.
Localization (secretion) of IL-6 in spleen associated with adenocard and agonist
15) Confidence 0.79 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 11960643 Disease Relevance 0 Pain Relevance 0.62
Furthermore, adenosine (at 5 x 10(-8), 10(-7), 5 x 10(-7) M) inhibited IL-6 secretion via A1 adenosine receptors, whereas an A2(A) adenosine receptor agonist increased IL-6 secretion in the presence of 10(-7) M cortisol.
Localization (secretion) of IL-6 associated with adenocard and agonist
16) Confidence 0.79 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 11960643 Disease Relevance 0 Pain Relevance 0.79
Electrical field stimulation markedly reduced IL-6 secretion, which was attenuated by the A1 antagonist DPCPX but not by the A2 antagonist 8-(3-Chlorostyryl)caffeine.
Localization (secretion) of IL-6 associated with antagonist
17) Confidence 0.79 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 11960643 Disease Relevance 0 Pain Relevance 0.78
The P2X(1) agonist beta,gamma-methylene ATP inhibited IL-6 secretion at 10(-5) M, whereas the P2Y(1) agonist 2-methylthio ATP increased IL-6 secretion at 10(-6) to 10(-8) M.
Localization (secretion) of IL-6 associated with agonist
18) Confidence 0.79 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 11960643 Disease Relevance 0 Pain Relevance 0.66
Thus, via A1 adenosine receptors, adenosine was found to be a strong inhibitor of splenic IL-6 secretion.
Localization (secretion) of IL-6 associated with adenocard
19) Confidence 0.79 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 11960643 Disease Relevance 0 Pain Relevance 0.73
Furthermore, adenosine (at 5 x 10(-8), 10(-7), 5 x 10(-7) M) inhibited IL-6 secretion via A1 adenosine receptors, whereas an A2(A) adenosine receptor agonist increased IL-6 secretion in the presence of 10(-7) M cortisol.
Localization (secretion) of IL-6 associated with adenocard and agonist
20) Confidence 0.79 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 11960643 Disease Relevance 0 Pain Relevance 0.78

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