INT11938

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Context Info
Confidence 0.70
First Reported 1992
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 61
Total Number 61
Disease Relevance 35.72
Pain Relevance 18.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) extracellular region (Il6)
Anatomy Link Frequency
peritoneal macrophages 12
Monocytes 6
elicited macrophages 6
macrophages 4
hepatocyte 4
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 578 100.00 Very High Very High Very High
cytokine 567 100.00 Very High Very High Very High
rheumatoid arthritis 146 100.00 Very High Very High Very High
Inflammatory mediators 62 100.00 Very High Very High Very High
metalloproteinase 52 100.00 Very High Very High Very High
Morphine 79 99.98 Very High Very High Very High
agonist 69 99.98 Very High Very High Very High
adenocard 172 99.64 Very High Very High Very High
substance P 51 99.58 Very High Very High Very High
chemokine 51 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 722 100.00 Very High Very High Very High
Rheumatoid Arthritis 147 100.00 Very High Very High Very High
Dehydration 49 100.00 Very High Very High Very High
Burns 24 100.00 Very High Very High Very High
Alzheimer's Dementia 16 100.00 Very High Very High Very High
Cancer 471 99.92 Very High Very High Very High
Injury 128 99.88 Very High Very High Very High
Sepsis 312 99.84 Very High Very High Very High
Disease 277 99.80 Very High Very High Very High
Cold Sores 72 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude from the complementary studies that the inhibition of IL-6 secretion induced by electrical pulses was mostly mediated by alpha-adrenergic and mu-opioidergic endogenous transmitters.
Positive_regulation (induced) of Localization (secretion) of IL-6
1) Confidence 0.70 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9084435 Disease Relevance 0 Pain Relevance 0.36
Methionine-enkephalin combined with interleukin-1beta or interferon-gamma caused an increase in IL-6 release from cultured macrophages.
Positive_regulation (increase) of Localization (release) of IL-6 in macrophages associated with enkephalin
2) Confidence 0.66 Published 2000 Journal Neuropeptides Section Abstract Doc Link 11021979 Disease Relevance 0 Pain Relevance 0.84
Moreover, RP67,580, a specific SP antagonist, eliminates the cold water stress-induced augmentation of IL-6 secretion from peritoneal macrophages.
Positive_regulation (augmentation) of Localization (secretion) of IL-6 in peritoneal macrophages associated with antagonist, dehydration and substance p
3) Confidence 0.62 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8642417 Disease Relevance 0.86 Pain Relevance 0.42
The 10 d stress time studies indicate that increased IL-6 secretion is positively related to elevated iSP in the peritoneal wash fluid and inversely related to reduced iSP in certain peritoneum-containing tissues.
Positive_regulation (increased) of Localization (secretion) of IL-6 in peritoneum associated with stress
4) Confidence 0.62 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8642417 Disease Relevance 0.92 Pain Relevance 0.39
We now report that the secretion of IL-6 from peritoneal macrophages is also increased after cold water stress and that the peptide substance P (SP) participates in this stress-induced response.
Positive_regulation (increased) of Localization (secretion) of IL-6 in peritoneal macrophages associated with stress, dehydration and substance p
5) Confidence 0.62 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8642417 Disease Relevance 0.79 Pain Relevance 0.17
Cold water stress augments the lipopolysaccharide-induced IL-6 secretion from peritoneal macrophages, elevates immunoreactive SP (iSP) in the peritoneal wash fluid, and reduces iSP in certain peritoneum-containing tissues or organs (i.e., diaphragm, abdominal wall, ileum, and rectum).
Positive_regulation (induced) of Localization (secretion) of IL-6 in peritoneal macrophages associated with dehydration and substance p
6) Confidence 0.62 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8642417 Disease Relevance 0.83 Pain Relevance 0.27
Cold water stress augments the lipopolysaccharide-induced IL-6 secretion from peritoneal macrophages, elevates immunoreactive SP (iSP) in the peritoneal wash fluid, and reduces iSP in certain peritoneum-containing tissues or organs (i.e., diaphragm, abdominal wall, ileum, and rectum).
Positive_regulation (augments) of Localization (secretion) of IL-6 in peritoneal macrophages associated with dehydration and substance p
7) Confidence 0.62 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8642417 Disease Relevance 0.84 Pain Relevance 0.27
Endogenous substance P mediates cold water stress-induced increase in interleukin-6 secretion from peritoneal macrophages.
Positive_regulation (increase) of Localization (secretion) of interleukin-6 in peritoneal macrophages associated with analgesic, dehydration and substance p
8) Confidence 0.62 Published 1996 Journal J. Neurosci. Section Title Doc Link 8642417 Disease Relevance 0.82 Pain Relevance 0.45
of fever; serum of patients stimulates further release of IL-6 within the first
Positive_regulation (stimulates) of Localization (release) of IL-6 associated with fever
9) Confidence 0.56 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276911 Disease Relevance 0.83 Pain Relevance 0.17
These data show that differential increases in [Ca(2+)](i) and IL-6 release occur in BEAS-2B epithelial cells and DRG sensory neurons, when exposed to PM derived from different sources.
Positive_regulation (occur) of Localization (release) of IL-6 in sensory neurons
10) Confidence 0.54 Published 2002 Journal Inhal Toxicol Section Abstract Doc Link 12122578 Disease Relevance 0.14 Pain Relevance 0.23
Experiments performed in vitro showed that pristane-elicited macrophages secreted low levels of IL-6 constitutively and high levels of IL-6 in the presence of lipopolysaccharide.
Positive_regulation (levels) of Localization (secreted) of IL-6 in elicited macrophages
11) Confidence 0.50 Published 1992 Journal Blood Section Abstract Doc Link 1611085 Disease Relevance 0.47 Pain Relevance 0.20
Experiments performed in vitro showed that pristane-elicited macrophages secreted low levels of IL-6 constitutively and high levels of IL-6 in the presence of lipopolysaccharide.
Positive_regulation (levels) of Localization (secreted) of IL-6 in elicited macrophages
12) Confidence 0.50 Published 1992 Journal Blood Section Abstract Doc Link 1611085 Disease Relevance 0.47 Pain Relevance 0.20
Experiments performed in vitro showed that pristane-elicited macrophages secreted low levels of IL-6 constitutively and high levels of IL-6 in the presence of lipopolysaccharide.
Positive_regulation (levels) of Localization (secreted) of IL-6 in elicited macrophages
13) Confidence 0.50 Published 1992 Journal Blood Section Abstract Doc Link 1611085 Disease Relevance 0.47 Pain Relevance 0.20
The P2X(1) agonist beta,gamma-methylene ATP inhibited IL-6 secretion at 10(-5) M, whereas the P2Y(1) agonist 2-methylthio ATP increased IL-6 secretion at 10(-6) to 10(-8) M.
Positive_regulation (increased) of Localization (secretion) of IL-6 associated with agonist
14) Confidence 0.50 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 11960643 Disease Relevance 0 Pain Relevance 0.75
Furthermore, adenosine (at 5 x 10(-8), 10(-7), 5 x 10(-7) M) inhibited IL-6 secretion via A1 adenosine receptors, whereas an A2(A) adenosine receptor agonist increased IL-6 secretion in the presence of 10(-7) M cortisol.
Positive_regulation (increased) of Localization (secretion) of IL-6 associated with adenocard and agonist
15) Confidence 0.50 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 11960643 Disease Relevance 0 Pain Relevance 0.79
We conclude from the complementary studies that the inhibition of IL-6 secretion induced by electrical pulses was mostly mediated by alpha-adrenergic and mu-opioidergic endogenous transmitters.
Positive_regulation (mediated) of Localization (secretion) of IL-6
16) Confidence 0.47 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9084435 Disease Relevance 0 Pain Relevance 0.36
Endogenous substance P mediates cold water stress-induced increase in interleukin-6 secretion from peritoneal macrophages.
Positive_regulation (stress-induced) of Localization (secretion) of interleukin-6 in peritoneal macrophages associated with analgesic, dehydration and substance p
17) Confidence 0.45 Published 1996 Journal J. Neurosci. Section Title Doc Link 8642417 Disease Relevance 0.82 Pain Relevance 0.45
Methionine-enkephalin added to the culture medium of resting macrophages increased IL-6 release from macrophages which were later induced with interleukin-1beta or interferon-gamma.
Positive_regulation (increased) of Localization (release) of IL-6 in macrophages associated with enkephalin
18) Confidence 0.44 Published 2000 Journal Neuropeptides Section Abstract Doc Link 11021979 Disease Relevance 0 Pain Relevance 0.87
Two hours thereafter, peritoneal (pMphi) and splenic macrophages (sMphi) were harvested and assessed not only for their ability to release IL-1 and IL-6, but also for cytokine gene expression using semiquantitative reverse transcription and PCR.
Positive_regulation (assessed) of Localization (release) of IL-6 in splenic macrophages associated with cytokine
19) Confidence 0.42 Published 1996 Journal J. Immunol. Section Abstract Doc Link 8955229 Disease Relevance 0.59 Pain Relevance 0.32
Growth factors stain in patches that do not correlate with the more sparse staining patterns of the TAF markers themselves due to the fact that the tumor cells also secrete the growth factors HGF, IL-6 and EGF in the presence of MSC as demonstrated by in vitro co-culture data (Figure S4).


Positive_regulation (presence) of Localization (secrete) of IL-6 in HGF associated with cancer
20) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 1.36 Pain Relevance 0.04

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