INT119380

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Context Info
Confidence 0.02
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 1.23
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (LPAR1) cytoplasm (LPAR1) signal transducer activity (LPAR1)
Anatomy Link Frequency
ovary 1
LPAR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropathic pain 13 99.98 Very High Very High Very High
Pain 5 99.38 Very High Very High Very High
allodynia 3 85.04 High High
Hyperalgesia 1 84.48 Quite High
Demyelination 3 83.40 Quite High
Kinase C 1 80.60 Quite High
Spinal cord 2 78.92 Quite High
Dorsal horn 2 78.44 Quite High
Calcium channel 1 76.96 Quite High
intrathecal 1 75.04 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 16 99.98 Very High Very High Very High
Nervous System Injury 2 86.32 High High
Hyperalgesia 1 84.48 Quite High
Demyelinating Disease 5 83.40 Quite High
Cancer 24 73.92 Quite High
Metastasis 10 73.48 Quite High
Hypercalcemia 1 62.76 Quite High
Breast Cancer 3 58.24 Quite High
Osteoporosis 3 53.68 Quite High
Bordatella Infection 2 49.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This response is likely to be mediated through LPA4, which, in contrast to the EDG family receptors, elevates cAMP and is highly expressed in the ovary (Noguchi et al., 2003).
Positive_regulation (elevates) of EDG in ovary
1) Confidence 0.02 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.51 Pain Relevance 0
Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling.
Positive_regulation (requires) of lysophosphatidic acid receptor associated with pain and neuropathic pain
2) Confidence 0.02 Published 2004 Journal Nat. Med. Section Title Doc Link 15195086 Disease Relevance 0.72 Pain Relevance 0.91

General Comments

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