INT119383

Context Info Confidence 0.59 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 11 Total Number 11 Disease Relevance 10.33 Pain Relevance 2.73

mitochondrion (Pten) aging (Pten) plasma membrane (Pten) nucleus (Pten) intracellular (Pten) enzyme binding (Pten)

Anatomy Link Frequency myocardium 1 blood 1 liver 1 cardiomyocyte 1 body 1 Pten (Rattus norvegicus)

Pain Link Frequency Relevance Heat Paracetamol 360 99.34 fibrosis 42 90.32 Dismenorea 4 88.32 Inflammation 9 83.08 cytokine 6 30.48 anesthesia 10 5.00 imagery 7 5.00 ketamine 3 5.00 Perioperative pain 3 5.00 ischemia 3 5.00

Disease Link Frequency Relevance Heat Myocardial Infarction 234 99.56 Aging 228 99.52 Hepatocellular Cancer 49 98.76 Diabetes Mellitus 165 98.16 Hyperglycemia 30 97.66 Hepatotoxicity 6 96.74 Body Weight 24 95.58 Apoptosis 181 94.20 Stress 24 93.96 Fibrosis 36 90.32

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Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It is thought that high glucose levels can result in decreased PTEN expression and decreases in PTEN phosphatase activity [14].

Gene_expression (expression) of PTEN

1) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.57 Pain Relevance 0.46

On the basis of previous work demonstrating that chronic acetaminophen (N-acetyl p-aminophenol, APAP) intake (30 mg/kg body weight/day) can be safely (e.g. in the absence of hepatotoxicity) used to prevent age-associated hyperglycemia [23], and other findings suggesting that elevated glucose levels can induce iNOS expression [19], [20] while reduce PTEN expression [14], we tested if this type of treatment regimen would also be effective in improving Akt function.

Gene_expression (expression) of PTEN in body associated with hyperglycemia, paracetamol, body weight and hepatotoxicity

2) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.99 Pain Relevance 0.22

It is possible that the normalization of blood glucose by acetaminophen may contribute to the increased PTEN expression.

Gene_expression (expression) of PTEN in blood associated with paracetamol

3) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.70 Pain Relevance 0.48

This increase in PTEN protein appeared to parallel decreases in the amount of Akt-Thr308 phosphorylation which support the notion that a loss of PTEN protein with aging may contribute to the hyper-phosphorylation of Akt, and that acetaminophen intervention may function in reducing Akt phosphorylation by increasing PTEN levels.

Gene_expression (levels) of PTEN associated with paracetamol and aging

4) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.51 Pain Relevance 0.40

Whether changes in PTEN expression alone or if the presence of other factors is required to explain the effects of aging on Akt expression and phosphorylation will require further investigation.

Gene_expression (expression) of PTEN associated with aging

5) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.93 Pain Relevance 0.37

Paradoxically, these increases in Akt phosphorylation were associated with diminished mammalian target of rapamycin (mTOR) phosphorylation, along with decreased levels of insulin receptor beta (IR-?)

Gene_expression (levels) of PTEN

6) Confidence 0.44 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2712760 Disease Relevance 0.35 Pain Relevance 0.22

As shown in Figure 4B, the relative gene expression of PTEN, P53, RhoC and RAS in SP from HCC cells were significantly lower than in fetal liver cells.

Gene_expression (expression) of PTEN in liver associated with hepatocellular cancer

7) Confidence 0.26 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3022676 Disease Relevance 0.60 Pain Relevance 0

PTEN expression was detected in all cases irrespective of the phase of the menstrual cycle or use of oral contraception.

Gene_expression (expression) of PTEN

8) Confidence 0.17 Published 2004 Journal Gynecol. Endocrinol. Section Abstract Doc Link 15195502 Disease Relevance 0.38 Pain Relevance 0.31

Our results showed that MI increased myocardial PTEN protein expression in GK but not in Wistar rats (Figure 5A).

Gene_expression (expression) of PTEN protein associated with myocardial infarction

9) Confidence 0.14 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 2.03 Pain Relevance 0.03

In GK rats, MI induced an increase in PTEN protein expression, reduced Akt phosphorylation and a concomitant decrease in FOXO3a phosphorylation which might have contributed to the increase in cardiomyocyte apoptosis seen here.

Gene_expression (expression) of PTEN protein in cardiomyocyte associated with apoptosis and myocardial infarction

10) Confidence 0.14 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.41 Pain Relevance 0.13

In the GK rat myocardium, Akt- and FOXO3a-phosphorylation was decreased and nuclear localization of FOXO3a was increased concomitantly with increased PTEN protein expression.

Gene_expression (expression) of PTEN protein in myocardium

11) Confidence 0.10 Published 2010 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC2835668 Disease Relevance 1.85 Pain Relevance 0.12

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