INT119396

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.61
First Reported 2004
Last Reported 2010
Negated 3
Speculated 4
Reported most in Body
Documents 22
Total Number 26
Disease Relevance 7.88
Pain Relevance 12.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk1) mitochondrion (Mapk1) protein complex (Mapk1)
cytoplasm (Mapk1) cytosol (Mapk1) signal transduction (Mapk1)
Anatomy Link Frequency
spinal cord 6
neuronal 4
hepatocytes 2
neurons 2
anterior 2
Mapk1 (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 280 100.00 Very High Very High Very High
amygdala 79 100.00 Very High Very High Very High
Spinal cord 58 100.00 Very High Very High Very High
qutenza 42 100.00 Very High Very High Very High
Hippocampus 42 100.00 Very High Very High Very High
Dorsal horn 24 100.00 Very High Very High Very High
Dynorphin 5 100.00 Very High Very High Very High
Pain 54 99.96 Very High Very High Very High
Morphine 29 99.86 Very High Very High Very High
Spinal sensitization 2 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 217 100.00 Very High Very High Very High
Pain 77 99.96 Very High Very High Very High
Reprotox - General 1 41 99.64 Very High Very High Very High
Neurodegenerative Disease 9 99.36 Very High Very High Very High
INFLAMMATION 128 98.16 Very High Very High Very High
Ganglion Cysts 22 98.16 Very High Very High Very High
Injury 15 98.08 Very High Very High Very High
Cognitive Disorder 7 97.72 Very High Very High Very High
Nociception 41 97.40 Very High Very High Very High
Targeted Disruption 49 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Role of ERK activation in long term behavioral effects of drugs of abuse
Regulation (Role) of Positive_regulation (activation) of ERK
1) Confidence 0.61 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1420315 Disease Relevance 0 Pain Relevance 0.86
The present study was designed to determine whether high-dose i.t. morphine could influence the activation of the extracellular signal-regulated kinase (ERK), a mitogen-activated protein (MAP) kinase in neuronal nitric oxide synthase (nNOS) and inducible NOS (iNOS) activation.
Regulation (influence) of Positive_regulation (activation) of extracellular signal-regulated kinase in neuronal associated with neuronal nitric oxide synthase and morphine
2) Confidence 0.55 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17353023 Disease Relevance 0.17 Pain Relevance 0.67
Taken together, these results indicate that the activation of ERK in LTP induction is not dependent on specific induction paradigms.


Neg (not) Regulation (dependent) of Positive_regulation (activation) of ERK associated with long-term potentiation
3) Confidence 0.48 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.64
We hypothesized that activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) and the expression of c-Fos, prodynorphin (mRNA), and dynorphin in the spinal cord could participate in the molecular mechanisms underlying postoperative opioid-induced sensitization.
Regulation (participate) of Positive_regulation (activation) of extracellular signal-regulated kinases 1 and 2 in spinal cord associated with dynorphin, opioid and spinal cord
4) Confidence 0.45 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 19917879 Disease Relevance 0.33 Pain Relevance 0.95
Interestingly, capsaicin decreased ERK activation in the hippocampus, suggesting that reduced ERK signaling may be involved in the capsaicin-mediated regulation of hippocampal neurogenesis.
Regulation (regulation) of Positive_regulation (activation) of ERK in hippocampus associated with qutenza, hippocampus and neurodegenerative disease
5) Confidence 0.45 Published 2010 Journal J. Toxicol. Environ. Health Part A Section Abstract Doc Link 20954075 Disease Relevance 0.57 Pain Relevance 0.85
Capsaicin decreased the activation of extracellular signal-regulated kinases (ERK) without markedly affecting p38 kinases.
Neg (without) Regulation (affecting) of Positive_regulation (activation) of ERK associated with qutenza
6) Confidence 0.45 Published 2010 Journal J. Toxicol. Environ. Health Part A Section Abstract Doc Link 20954075 Disease Relevance 0.51 Pain Relevance 0.87
In the present study, we tested whether ERK activation in the right CeA modulates pain independently of the side of peripheral inflammation by injecting formalin into the left hind-paw and then infusing U0126, U0124 or vehicle into the right CeA.
Spec (whether) Regulation (modulates) of Spec (whether) Positive_regulation (activation) of ERK in paw associated with pain, inflammation and amygdala
7) Confidence 0.43 Published 2008 Journal Mol Pain Section Body Doc Link PMC2443116 Disease Relevance 0.52 Pain Relevance 0.55
These results showed that DHEAS prevented the development of morphine tolerance and dependence and suggested that the attenuating effects of DHEAS might result from the regulation of c-fos mRNA expression, which is possibly involved the signaling activation of ERK, but not of cAMP pathway.
Regulation (regulation) of Spec (possibly) Positive_regulation (activation) of ERK associated with addiction, tolerance and morphine
8) Confidence 0.43 Published 2004 Journal Behav. Brain Res. Section Abstract Doc Link 15196791 Disease Relevance 0.35 Pain Relevance 1.48
Although basal phosphorylated ERK is minimal in mouse spinal cords without noxious stimuli, we investigated whether expression of the DN MEK transgene would alter basal ERK activation in the DN MEK mice.
Spec (whether) Regulation (alter) of Spec (whether) Positive_regulation (activation) of ERK in spinal cords
9) Confidence 0.43 Published 2006 Journal Mol Pain Section Body Doc Link PMC1382249 Disease Relevance 0.50 Pain Relevance 0.40
The present study was designed to determine whether high-dose i.t. morphine could influence the activation of the extracellular signal-regulated kinase (ERK), a mitogen-activated protein (MAP) kinase in neuronal nitric oxide synthase (nNOS) and inducible NOS (iNOS) activation.
Regulation (influence) of Positive_regulation (activation) of ERK in neuronal associated with neuronal nitric oxide synthase and morphine
10) Confidence 0.41 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17353023 Disease Relevance 0.17 Pain Relevance 0.67
The effects of Hcy on ERK cascade activation were also dependent on calcium influx, CaMK-II, PKC as well as PKA activation.
Regulation (effects) of Positive_regulation (activation) of ERK
11) Confidence 0.37 Published 2005 Journal Neuroscience Section Abstract Doc Link 15916860 Disease Relevance 0.20 Pain Relevance 0.30
By employing a model deficient for c-met exclusively in hepatocytes, we found that c-met ablation affected neither early hepatic Erk1/2 activation nor induction of the initial round of DNA replication.
Neg (nor) Regulation (affected) of Neg (neither) Positive_regulation (activation) of Erk1/2 in hepatocytes
12) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0 Pain Relevance 0
Recently, we have shown that the postsynaptic inhibition of the ERK pathway blocked LTP in superficial dorsal horn neurons [48], suggesting that the ERK activation in the superficial dorsal horn of the spinal cord can be pathophysiologically related to spinal sensitization and chronic pain after injury.
Regulation (related) of Positive_regulation (activation) of ERK in spinal cord associated with lasting pain, spinal sensitization, injury, dorsal horn, long-term potentiation, dorsal horn neuron and spinal cord
13) Confidence 0.35 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0.27 Pain Relevance 0.76
(Fig. 4A-B), although in the latter the degree of ERK activation is similar to that in TNF?
Regulation (degree) of Positive_regulation (activation) of ERK
14) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.20 Pain Relevance 0.03
Furthermore, we performed an analysis of intracellular signaling mechanisms that could mediate the actions of 3-MT on hTAAR1 expressed in HEK cells. 3-MT caused a rapid and prolonged phosphorylation of Erk2 and CREB only in cells expressing hTAAR1 (Figure 2B,C) thus indicating that a Gs-dependent signaling cascade involving accumulation of cAMP and activation of Erk2 and CREB is likely involved in the action of TAAR1.


Regulation (involved) of Positive_regulation (activation) of Erk2
15) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956650 Disease Relevance 0.15 Pain Relevance 0.10
Role of ERK activation in behavioral sensitization to psychostimulants
Regulation (Role) of Positive_regulation (activation) of ERK
16) Confidence 0.27 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1420315 Disease Relevance 0 Pain Relevance 0.31
Roles of the AMPA receptor subunit GluA1 but not GluA2 in synaptic potentiation and activation of ERK in the anterior cingulate cortex

Cortical areas including the anterior cingulate cortex (ACC) are important for pain and pleasure.

Regulation (Roles) of Positive_regulation (activation) of ERK in anterior associated with pain and anterior cingulate cortex
17) Confidence 0.25 Published 2009 Journal Mol Pain Section Title Doc Link PMC2734546 Disease Relevance 0.31 Pain Relevance 0.83
Our preliminary studies demonstrate that IL-6 expression by PC3, a line of hormone refractory prostate cancer cells is in part regulated by ERK signal transduction pathway (Koul et al in press]
Regulation (regulated) of Positive_regulation (pathway) of ERK associated with reprotox - general 1
18) Confidence 0.25 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.58 Pain Relevance 0.03
Alternatively, we cannot exclude that another kinase in addition to Tpl2 is involved in ERK activation.
Regulation (involved) of Positive_regulation (activation) of ERK
19) Confidence 0.19 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.61 Pain Relevance 0.24
PKC is able to phosphorylate Ng through serine and it is also involved in ERK activation by various stimuli 25, 2.
Regulation (involved) of Positive_regulation (activation) of ERK associated with kinase c
20) Confidence 0.16 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1865092 Disease Relevance 0 Pain Relevance 0.26

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox