INT11941

Context Info Confidence 0.14 First Reported 1992 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 2.18 Pain Relevance 0.35

plasma membrane (Slc11a1) molecular_function (Slc11a1) cellular_component (Slc11a1) biological_process (Slc11a1) lysosome (Slc11a1)

Anatomy Link Frequency urine 1 Slc11a1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat interstitial cystitis 4 99.50 anesthesia 1 76.92 Eae 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Interstitial Cystitis 4 99.50 Disease Progression 3 99.20 Recurrence 17 97.96 Cancer 24 97.80 Carcinoma In Situ 52 94.40 Fever 16 85.04 Toxicity 2 78.48 Bladder Cancer 4 75.00 Carcinoma 3 52.68 Disease 5 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Immunotherapy, as exemplified by Bacillus Calmette-Guérin (BCG), has achieved better results: long-term reduction in tumor recurrence, reduction in disease progression and prolongation of patient survival.

BCG Binding (exemplified) of associated with cancer, disease progression and recurrence

1) Confidence 0.14 Published 1992 Journal Anticancer Drugs Section Abstract Doc Link 1611116 Disease Relevance 0.99 Pain Relevance 0.08

Intravesical approaches have failed, such as valrubicin [9], are investigational, such as gemcitabine [10] and mycobacterial cell wall preparations [11], or efficacy should be confirmed, such as the combination of BCG and interferon-alpha 2b [12].

BCG Binding (combination) of

2) Confidence 0.01 Published 2009 Journal World J Urol Section Body Doc Link PMC2694311 Disease Relevance 0.92 Pain Relevance 0

We measured candidate urine biomarkers and bladder cell DNA cytometry in interstitial cystitis (IC) patients randomized to receive intravesical Bacillus Calmette Guerin (BCG) or placebo in a multicenter trial.

BCG Binding (receive) of in urine associated with interstitial cystitis

3) Confidence 0.01 Published 2007 Journal World J Urol Section Abstract Doc Link 17694391 Disease Relevance 0.27 Pain Relevance 0.27

General Comments

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