INT11942

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Context Info
Confidence 0.47
First Reported 1992
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.23
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Chat) transferase activity, transferring acyl groups (Chat)
Anatomy Link Frequency
peripheral neurons 2
frontal cortex 2
Chat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 2 89.60 High High
Central nervous system 2 75.00 Quite High
Opioid 2 75.00 Quite High
Pyramidal cell 6 59.96 Quite High
Hippocampus 1 57.84 Quite High
midbrain 2 55.84 Quite High
cerebral cortex 8 17.16 Low Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
Bile 4 5.00 Very Low Very Low Very Low
Endogenous opioid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 10 95.88 Very High Very High Very High
Cirrhosis 19 5.00 Very Low Very Low Very Low
Hepatic Encephalopathy 17 5.00 Very Low Very Low Very Low
Cognitive Disorder 11 5.00 Very Low Very Low Very Low
Liver Failure 10 5.00 Very Low Very Low Very Low
Liver Disease 8 5.00 Very Low Very Low Very Low
Hyperammonemia 4 5.00 Very Low Very Low Very Low
Shock 2 5.00 Very Low Very Low Very Low
Dementia 1 5.00 Very Low Very Low Very Low
End Stage Liver Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For the first time we report that these changes were associated with a compensatory increase in the activity of ChAT (+27%), AChE (+25%), beta-End level (+66%) in the remaining part of the cortex, i.e. cortex devoid of frontal cortex (C-FC).
Positive_regulation (increase) of Transcription (activity) of ChAT in frontal cortex associated with urological neuroanatomy
1) Confidence 0.47 Published 1992 Journal Brain Res. Section Abstract Doc Link 1611500 Disease Relevance 0.23 Pain Relevance 0.48
QRT-PCR analysis was used to determine the mRNA levels for both the conventional cholinergic ChAT transcript, the major variant found in both central and peripheral neurons [protein product is called ChAT of the common type (cChAT)], and also transcriptional levels for the minor splice variant [protein product designated ChAT of a peripheral type (pChAT)], which is predominantly localized in peripheral neurons (Tooyama and Kimura, 2000).
Spec (determine) Positive_regulation (levels) of Spec (determine) Transcription (levels) of ChAT in peripheral neurons
2) Confidence 0.30 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0 Pain Relevance 0.06

General Comments

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