INT119420

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Context Info
Confidence 0.79
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 4.89
Pain Relevance 3.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAP2K6) nucleoplasm (MAP2K6) signal transduction (MAP2K6)
cytoskeleton (MAP2K6) nucleus (MAP2K6) response to stress (MAP2K6)
Anatomy Link Frequency
chondrocytes 4
brains 1
MAP2K6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 515 99.60 Very High Very High Very High
opiate 13 97.08 Very High Very High Very High
Morphine 67 92.24 High High
addiction 3 89.52 High High
metalloproteinase 32 88.48 High High
cytokine 40 85.04 High High
cINOD 5 83.48 Quite High
opioid receptor 10 70.24 Quite High
Opioid 13 50.00 Quite Low
Analgesic 5 49.64 Quite Low
Disease Link Frequency Relevance Heat
Osteoarthritis 520 99.60 Very High Very High Very High
Targeted Disruption 15 95.92 Very High Very High Very High
Urological Neuroanatomy 3 94.32 High High
Apoptosis 10 93.96 High High
Cancer 20 90.60 High High
Opiate Addiction 3 89.52 High High
Stress 6 89.00 High High
Colon Cancer 2 85.96 High High
INFLAMMATION 73 75.00 Quite High
Congenital Anomalies 1 71.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sevoflurane exposure also induced phosphorylation of apoptosis signal-regulating kinase-1 (ASK1), MAP kinase kinases 3 and 6 (MKK3/MKK6), and ATF-2.
Phosphorylation (phosphorylation) of MKK6
1) Confidence 0.79 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18349187 Disease Relevance 0.07 Pain Relevance 0
Our results indicated that although both MKK3 and MKK6 were constitutively phosphorylated in the human OA chondrocytes (probably refecting the pre-activated state), but the effect of IL-1?
Phosphorylation (phosphorylated) of MKK6 in chondrocytes associated with osteoarthritis
2) Confidence 0.74 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.61 Pain Relevance 0.30
Higher concentrations produced no additional suppression of phosphorylation of either MKK3 or MKK6 in human OA chondrocytes.


Phosphorylation (phosphorylation) of MKK6 in chondrocytes associated with osteoarthritis
3) Confidence 0.73 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 1.02 Pain Relevance 0.43
-induced phosphorylation of both MKK3 and MKK6 in a dose dependent manner with the maximum inhibitory effect of PE being at 50 ?
Phosphorylation (phosphorylation) of MKK6
4) Confidence 0.73 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.91 Pain Relevance 0.42
We then used these antibodies to determine the expression and phosphorylation of MKK3 and MKK6 proteins in human OA chondrocytes.
Spec (determine) Phosphorylation (phosphorylation) of MKK6 in chondrocytes associated with osteoarthritis
5) Confidence 0.57 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.51 Pain Relevance 0.25
Our results show that both MKK3 and MKK6 were constitutively phosphorylated in the primary human OA chondrocytes but the intensity of MKK3 phosphorylation was significantly enhanced (P < 0.05) after stimulation with IL-1?
Phosphorylation (phosphorylated) of MKK6 in chondrocytes associated with osteoarthritis
6) Confidence 0.57 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.60 Pain Relevance 0.30
MEK inhibitors, PD98059 and U-0126, which inhibited ERK phosphorylation were shown to elevate 15-PGDH levels very significantly.
Phosphorylation (phosphorylation) of MEK
7) Confidence 0.17 Published 2009 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 19501039 Disease Relevance 0.54 Pain Relevance 0.45
Notably, pronounced downregulations of phosphorylated MEK (85%) and ERK1/2 (pERK1: 81%; pERK2: 80%) were quantitated in brains of opiate addicts.
Phosphorylation (phosphorylated) of MEK in brains associated with opiate
8) Confidence 0.10 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15198681 Disease Relevance 0.47 Pain Relevance 0.86
The basic arrangement includes a sensor (receptor) working upstream of a core module consisting of three kinases: a MAPK kinase kinase (MAPKKK) that phosphorylates and activates a MAPK kinase (MAPKK), which in turn activates MAPK.6 But also many receptors tyrosine kinases have been shown to activate the MAPK pathway.7 Previous studies have proposed nitric oxide (NO) as being the downstream mediator of the morphine effects.
Phosphorylation (phosphorylates) of MAPKK associated with morphine
9) Confidence 0.06 Published 2009 Journal Journal of pain research Section Body Doc Link PMC3004619 Disease Relevance 0.16 Pain Relevance 0.52

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