INT119422

Context Info Confidence 0.38 First Reported 2004 Last Reported 2010 Negated 1 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 2.09 Pain Relevance 1.76

cytosol (MAP2K6) nucleoplasm (MAP2K6) signal transduction (MAP2K6) cytoskeleton (MAP2K6) nucleus (MAP2K6) response to stress (MAP2K6)

Anatomy Link Frequency chondrocytes 2 brains 2 MAP2K6 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 103 99.60 opiate 7 97.08 Morphine 2 92.24 addiction 3 90.28 metalloproteinase 8 88.48 cINOD 5 83.48 opioid receptor 1 67.92 Inflammation 16 5.00 cytokine 8 5.00 Arthritis 8 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 104 99.60 Targeted Disruption 3 95.92 Urological Neuroanatomy 3 95.08 Cancer 3 90.60 Opiate Addiction 3 90.28 Colon Cancer 2 85.96 INFLAMMATION 16 75.00 Congenital Anomalies 1 71.28 Arthritis 9 5.00 Disease 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Higher concentrations produced no additional suppression of phosphorylation of either MKK3 or MKK6 in human OA chondrocytes.

Neg (no) Negative_regulation (suppression) of Phosphorylation (phosphorylation) of MKK6 in chondrocytes associated with osteoarthritis

1) Confidence 0.38 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 1.07 Pain Relevance 0.45

MEK inhibitors, PD98059 and U-0126, which inhibited ERK phosphorylation were shown to elevate 15-PGDH levels very significantly.

Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of MEK

2) Confidence 0.09 Published 2009 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 19501039 Disease Relevance 0.54 Pain Relevance 0.45

Notably, pronounced downregulations of phosphorylated MEK (85%) and ERK1/2 (pERK1: 81%; pERK2: 80%) were quantitated in brains of opiate addicts.

Negative_regulation (downregulations) of Phosphorylation (phosphorylated) of MEK in brains associated with opiate

3) Confidence 0.05 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15198681 Disease Relevance 0.47 Pain Relevance 0.86

General Comments

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