INT11943

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Context Info
Confidence 0.70
First Reported 1986
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 10
Total Number 12
Disease Relevance 1.55
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Chat) transferase activity, transferring acyl groups (Chat)
Anatomy Link Frequency
cortex 3
pancreas 2
Neurons 2
spinal cord 1
peripheral neurons 1
Chat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 2 100.00 Very High Very High Very High
Spinal cord 6 99.32 Very High Very High Very High
Glutamate 2 99.20 Very High Very High Very High
GABAergic 2 97.92 Very High Very High Very High
Opioid 7 97.44 Very High Very High Very High
tetrodotoxin 4 95.60 Very High Very High Very High
withdrawal 1 92.48 High High
Enkephalin 2 89.60 High High
Buprenorphine 1 86.20 High High
methadone 1 85.52 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 24 95.88 Very High Very High Very High
Generalized Anxiety Disorder 22 91.60 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

2 91.20 High High
Neuropathic Pain 6 87.60 High High
Shock 8 68.52 Quite High
Pancreatic Cancer 8 50.00 Quite Low
Pancreatitis 4 50.00 Quite Low
Cirrhosis 57 5.00 Very Low Very Low Very Low
Hepatic Encephalopathy 51 5.00 Very Low Very Low Very Low
Cognitive Disorder 33 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neurons were identified by mRNA expression of choline acetyltransferase (ChAT+, cholinergic) and glutamate decarboxylase (GAD67, GABAergic).
Transcription (expression) of ChAT in Neurons associated with glutamate and gabaergic
1) Confidence 0.70 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15836920 Disease Relevance 0.42 Pain Relevance 0.27
Neurons were identified by mRNA expression of choline acetyltransferase (ChAT+, cholinergic) and glutamate decarboxylase (GAD67, GABAergic).
Transcription (expression) of choline acetyltransferase in Neurons associated with glutamate and gabaergic
2) Confidence 0.70 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15836920 Disease Relevance 0.41 Pain Relevance 0.27
Distribution of choline acetyltransferase activity in rat spinal cord--influence of primary afferents?
Transcription (Distribution) of choline acetyltransferase in spinal cord associated with qutenza and spinal cord
3) Confidence 0.69 Published 1986 Journal J. Neural Transm. Section Title Doc Link 3746289 Disease Relevance 0 Pain Relevance 0.51
Acetylcholinesterase (AChE) and choline acetyltransferase (ChAT) activities in cortex were similar in experimental and control groups.
Transcription (activities) of ChAT in cortex
4) Confidence 0.68 Published 1986 Journal Brain Res. Section Abstract Doc Link 3013361 Disease Relevance 0.07 Pain Relevance 0.05
Acetylcholinesterase (AChE) and choline acetyltransferase (ChAT) activities in cortex were similar in experimental and control groups.
Transcription (activities) of choline acetyltransferase in cortex
5) Confidence 0.68 Published 1986 Journal Brain Res. Section Abstract Doc Link 3013361 Disease Relevance 0.07 Pain Relevance 0.05
For the first time we report that these changes were associated with a compensatory increase in the activity of ChAT (+27%), AChE (+25%), beta-End level (+66%) in the remaining part of the cortex, i.e. cortex devoid of frontal cortex (C-FC).
Transcription (activity) of ChAT in frontal cortex associated with urological neuroanatomy
6) Confidence 0.65 Published 1992 Journal Brain Res. Section Abstract Doc Link 1611500 Disease Relevance 0.23 Pain Relevance 0.48
Acetylcholine (ACh) content and the expression of choline acetyltransferase protein and mRNA are reduced in the early postnatal period by prenatal opioid exposure in the rat.
Transcription (expression) of choline acetyltransferase protein associated with opioid
7) Confidence 0.63 Published 2000 Journal J. Biomed. Sci. Section Abstract Doc Link 10810245 Disease Relevance 0 Pain Relevance 0.67
Fig. 5Immunodetection of AChE subunits and detection of AChE and ChAT transcripts in brain cortex from NL and BDL rats.
Transcription (transcripts) of ChAT in cortex
8) Confidence 0.47 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0 Pain Relevance 0
RNA isolation and analysis of AChE and ChAT transcripts by QRT-PCR
Transcription (transcripts) of ChAT
9) Confidence 0.47 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0 Pain Relevance 0
QRT-PCR analysis was used to determine the mRNA levels for both the conventional cholinergic ChAT transcript, the major variant found in both central and peripheral neurons [protein product is called ChAT of the common type (cChAT)], and also transcriptional levels for the minor splice variant [protein product designated ChAT of a peripheral type (pChAT)], which is predominantly localized in peripheral neurons (Tooyama and Kimura, 2000).
Spec (determine) Transcription (levels) of ChAT in peripheral neurons
10) Confidence 0.43 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0 Pain Relevance 0.06
METHODS: Pancreatic nerve fiber qualities were characterized by immunohistochemical visualization of various markers, including those for sympathetic (tyrosine hydroxylase, TH) and cholinergic innervation (choline acetyltransferase, ChAT), as well as the glial transcription factor, Sox10, and the neuroepithelial progenitor cell marker, Nestin, in normal pancreas (NP, n=16), CP (n=20), and PCa (n=20) patients.
Transcription (transcription factor) of ChAT in pancreas
11) Confidence 0.12 Published 2009 Journal Am. J. Gastroenterol. Section Body Doc Link 19568227 Disease Relevance 0.09 Pain Relevance 0
METHODS: Pancreatic nerve fiber qualities were characterized by immunohistochemical visualization of various markers, including those for sympathetic (tyrosine hydroxylase, TH) and cholinergic innervation (choline acetyltransferase, ChAT), as well as the glial transcription factor, Sox10, and the neuroepithelial progenitor cell marker, Nestin, in normal pancreas (NP, n=16), CP (n=20), and PCa (n=20) patients.
Transcription (transcription factor) of choline acetyltransferase in pancreas
12) Confidence 0.05 Published 2009 Journal Am. J. Gastroenterol. Section Body Doc Link 19568227 Disease Relevance 0.09 Pain Relevance 0

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