INT119443

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Context Info
Confidence 0.65
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.41
Pain Relevance 3.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Rgs7) plasma membrane (Rgs7) nucleus (Rgs7)
cytoplasm (Rgs7) signal transducer activity (Rgs7)
Anatomy Link Frequency
neural 2
brain 1
Rgs7 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 114 97.88 Very High Very High Very High
Morphine 112 97.84 Very High Very High Very High
Intracerebroventricular 6 96.24 Very High Very High Very High
Central grey 3 91.20 High High
tolerance 50 90.16 High High
Analgesic 20 88.80 High High
Nucleus accumbens 1 87.04 High High
Opioid 52 84.00 Quite High
Spinal cord 3 79.24 Quite High
Thalamus 6 78.64 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 24 91.68 High High
Drug Dependence 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Nociception 2 5.00 Very Low Very Low Very Low
Inflammatory Pain 2 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of neural RGS-R7 and Gbeta5 Proteins in Response to Acute and Chronic Morphine.
Gene_expression (Expression) of RGS-R7 in neural associated with morphine
1) Confidence 0.65 Published 2005 Journal Neuropsychopharmacology Section Title Doc Link 15199376 Disease Relevance 0.23 Pain Relevance 0.86
The R7 subfamily of regulators of G-protein signaling (RGS) proteins (RGS6, RGS7, RGS9-2, and RGS11), and its binding protein Gbeta5, are found in neural structures of mouse brain.
Gene_expression (found) of RGS7 in brain
2) Confidence 0.65 Published 2005 Journal Neuropsychopharmacology Section Abstract Doc Link 15199376 Disease Relevance 0 Pain Relevance 0.67
RGS7 and RGS11 present in this neural structure showed no association with MOR.
Gene_expression (present) of RGS7 in neural associated with opioid receptor
3) Confidence 0.64 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15632124 Disease Relevance 0.18 Pain Relevance 0.60
For example, the expression of certain RGS proteins such as members of RGSZ1, RGSZ2, RGS-R7 subfamily, and of G?
Gene_expression (expression) of RGS-R7
4) Confidence 0.05 Published 2007 Journal Mol Pain Section Body Doc Link PMC1947952 Disease Relevance 0 Pain Relevance 0.92

General Comments

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