INT119448

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.46
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Rgs7) plasma membrane (Rgs7) nucleus (Rgs7)
cytoplasm (Rgs7) signal transducer activity (Rgs7)
Anatomy Link Frequency
gray matter 1
striatum 1
Rgs7 (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 8 99.96 Very High Very High Very High
Morphine 14 99.68 Very High Very High Very High
Thalamus 6 97.68 Very High Very High Very High
Central grey 2 96.04 Very High Very High Very High
Analgesic 2 95.84 Very High Very High Very High
tolerance 4 95.16 Very High Very High Very High
Intracerebroventricular 2 92.68 High High
addiction 2 37.60 Quite Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 8 96.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At 2 h after administering the acute opioid, RGS7 mRNA levels in the striatum plus those of RGS9-2 in the striatum and thalamus were increased, whereas RGS9-2 and RGS11 mRNA were reduced in the cortex.
Transcription (levels) of RGS7 in striatum associated with thalamus and opioid
1) Confidence 0.69 Published 2005 Journal Neuropsychopharmacology Section Abstract Doc Link 15199376 Disease Relevance 0.12 Pain Relevance 0.91
At 2 days after commencing sustained morphine treatment, the levels of mRNA for RGS7, RGS9-2, RGS11, and Gbeta5 increased in most of the brain structures studied (striatum, thalamus, periaqueductal gray matter (PAG), and cortex).
Transcription (levels) of RGS7 in gray matter associated with urological neuroanatomy, thalamus, central grey and morphine
2) Confidence 0.51 Published 2005 Journal Neuropsychopharmacology Section Abstract Doc Link 15199376 Disease Relevance 0.34 Pain Relevance 1.07

General Comments

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