INT11945

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Context Info
Confidence 0.62
First Reported 1980
Last Reported 2010
Negated 7
Speculated 1
Reported most in Abstract
Documents 38
Total Number 39
Disease Relevance 7.75
Pain Relevance 14.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Chat) transferase activity, transferring acyl groups (Chat)
Anatomy Link Frequency
brain 8
frontal cortex 4
neurons 3
striatum 2
cholinergic neurons 2
Chat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 151 100.00 Very High Very High Very High
Morphine 41 100.00 Very High Very High Very High
Enkephalin 34 100.00 Very High Very High Very High
Glutamate 33 100.00 Very High Very High Very High
substance P 28 100.00 Very High Very High Very High
Serotonin 11 100.00 Very High Very High Very High
Neuropeptide 9 100.00 Very High Very High Very High
Somatostatin 8 100.00 Very High Very High Very High
Catecholamine 5 100.00 Very High Very High Very High
Cholecystokinin 3 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 27 100.00 Very High Very High Very High
Urological Neuroanatomy 41 99.84 Very High Very High Very High
Thyroid Disease 6 99.52 Very High Very High Very High
Death 54 99.24 Very High Very High Very High
Schizophrenia 222 98.68 Very High Very High Very High
Down Syndrome 3 98.68 Very High Very High Very High
Pain 17 98.56 Very High Very High Very High
Autism 8 98.28 Very High Very High Very High
Psychosis 7 98.12 Very High Very High Very High
Disease 90 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results demonstrate that neither short nor long-term morphine treatment had an effect on choline acetyltransferase (ChAT) activity or 3H-quinuclidinylbenzilate (3HQNB) binding in discrete striatal regions of the rat brain.
Regulation (effect) of choline acetyltransferase in brain associated with morphine
1) Confidence 0.62 Published 1983 Journal Life Sci. Section Abstract Doc Link 6685808 Disease Relevance 0 Pain Relevance 0.34
The results demonstrate that neither short nor long-term morphine treatment had an effect on choline acetyltransferase (ChAT) activity or 3H-quinuclidinylbenzilate (3HQNB) binding in discrete striatal regions of the rat brain.
Regulation (effect) of ChAT in brain associated with morphine
2) Confidence 0.62 Published 1983 Journal Life Sci. Section Abstract Doc Link 6685808 Disease Relevance 0 Pain Relevance 0.34
Differential effects of fasciculus retroflexus lesions on serotonin, glutamate and gamma-aminobutyrate content and choline acetyltransferase activity in the interpeduncular nucleus.
Regulation (effects) of choline acetyltransferase activity in interpeduncular nucleus associated with glutamate and serotonin
3) Confidence 0.62 Published 1990 Journal Brain Res. Bull. Section Title Doc Link 2271960 Disease Relevance 0 Pain Relevance 0.84
These results, taken together, indicate that IGF-I, under acute conditions, can decrease hippocampal ACh release by acting on the typical IGF-I/IRS receptor complex while having no direct effect on ChAT activity or the uptake of choline.
Neg (no) Regulation (effect) of ChAT
4) Confidence 0.53 Published 2002 Journal Neuroscience Section Abstract Doc Link 12421625 Disease Relevance 0 Pain Relevance 0.45
The effects of striatal dopamine denervation and levodopa replacement therapy on neuronal populations in the rat striatum were assessed by measurement of glutamic acid decarboxylase (GAD) and choline acetyltransferase (CAT) activities in the striatum, dynorphin and substance P concentrations in the substantia nigra, and enkephalin concentration in the globus pallidus.
Regulation (measurement) of CAT in striatum associated with dopamine, dynorphin, generalized anxiety disorder, substantia nigra, enkephalin and substance p
5) Confidence 0.44 Published 1991 Journal Brain Res. Section Abstract Doc Link 1717109 Disease Relevance 0.16 Pain Relevance 0.41
GAD and enkephalin) or altered neurochemical markers which had been unaffected by the lesion (e.g.
Regulation (unaffected) of CAT associated with generalized anxiety disorder and enkephalin
6) Confidence 0.44 Published 1991 Journal Brain Res. Section Abstract Doc Link 1717109 Disease Relevance 0.23 Pain Relevance 0.56
The effects of learning memory tasks on activities of choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) in the frontal cortex (FC), hippocampus (HC) and cerebellum of aged rat brains were studied in comparison with those of young adult rats.
Regulation (effects) of choline acetyltransferase in frontal cortex associated with urological neuroanatomy and hippocampus
7) Confidence 0.43 Published 1989 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2623034 Disease Relevance 0.27 Pain Relevance 0.13
The effects of learning memory tasks on activities of choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) in the frontal cortex (FC), hippocampus (HC) and cerebellum of aged rat brains were studied in comparison with those of young adult rats.
Regulation (effects) of ChAT in frontal cortex associated with urological neuroanatomy and hippocampus
8) Confidence 0.43 Published 1989 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2623034 Disease Relevance 0.27 Pain Relevance 0.13
Injection of IA in the NBM did not cause a change in the activity of ChAT or AChE in other brain regions such as hippocampus, striatum or midbrain.
Regulation (change) of ChAT in brain associated with midbrain and hippocampus
9) Confidence 0.42 Published 1992 Journal Brain Res. Section Abstract Doc Link 1611500 Disease Relevance 0.27 Pain Relevance 0.49
Differential effects of insulin on choline acetyltransferase and glutamic acid decarboxylase activities in neuron-rich striatal cultures.
Regulation (effects) of choline acetyltransferase in neuron
10) Confidence 0.42 Published 1992 Journal J. Neurochem. Section Title Doc Link 1629717 Disease Relevance 0.33 Pain Relevance 0.51
In the present study, we have characterized the possible involvement of GABA in IGF-I-mediated inhibition of ACh release and measured the effects of this growth factor on choline acetyltransferase (ChAT) activity and high-affinity choline uptake in the hippocampus of the adult rat brain.
Regulation (effects) of ChAT in brain associated with gaba and hippocampus
11) Confidence 0.39 Published 2002 Journal Neuroscience Section Abstract Doc Link 12421625 Disease Relevance 0 Pain Relevance 0.52
In the present study, we have characterized the possible involvement of GABA in IGF-I-mediated inhibition of ACh release and measured the effects of this growth factor on choline acetyltransferase (ChAT) activity and high-affinity choline uptake in the hippocampus of the adult rat brain.
Regulation (effects) of choline acetyltransferase in brain associated with gaba and hippocampus
12) Confidence 0.39 Published 2002 Journal Neuroscience Section Abstract Doc Link 12421625 Disease Relevance 0 Pain Relevance 0.52
Striatal choline acetyltransferase activity was not affected by 6-OHDA lesions.
Neg (not) Regulation (affected) of choline acetyltransferase
13) Confidence 0.38 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1899109 Disease Relevance 0 Pain Relevance 0.34
We have reinvestigated the effects of a specific antiserum to NGF on the morphology, catecholamine (CA) and neuropeptide (Met-enkephalin, Met-ENK; substance P, SP) content, and choline acetyltransferase (ChAT) activity of the rat adrenal medulla.
Regulation (effects) of ChAT in adrenal medulla associated with medulla, nerve growth factor, catecholamine, neuropeptide, enkephalin and substance p
14) Confidence 0.36 Published 1986 Journal Brain Res. Section Abstract Doc Link 2423196 Disease Relevance 0 Pain Relevance 0.86
The effects of striatal dopamine denervation and levodopa replacement therapy on neuronal populations in the rat striatum were assessed by measurement of glutamic acid decarboxylase (GAD) and choline acetyltransferase (CAT) activities in the striatum, dynorphin and substance P concentrations in the substantia nigra, and enkephalin concentration in the globus pallidus.
Regulation (measurement) of choline acetyltransferase in striatum associated with dopamine, dynorphin, generalized anxiety disorder, substantia nigra, enkephalin and substance p
15) Confidence 0.34 Published 1991 Journal Brain Res. Section Abstract Doc Link 1717109 Disease Relevance 0.16 Pain Relevance 0.41
The involvement of the hippocampal choline acetyltransferase (ChAT) activity in the response to tonic pain was investigated in rats injected with formalin, either 50 microliters 10% or 50 microliters 0.1%.
Regulation (involvement) of ChAT associated with pain
16) Confidence 0.27 Published 1993 Journal Brain Res. Section Abstract Doc Link 8287273 Disease Relevance 0.24 Pain Relevance 0.23
AChE reactivity was prominent in the neuropil of the rostral, lateral and dorsomedial subnuclei, whereas ChAT immunoreactivity was confined to axons and terminals in the rostral, intermediate and central subnuclei.
Regulation (immunoreactivity) of ChAT in neuropil
17) Confidence 0.27 Published 1990 Journal Brain Res. Bull. Section Abstract Doc Link 2337826 Disease Relevance 0 Pain Relevance 0.26
Expression profile of ChAT and p75 immunopositive septal cholinergic neurons after axotomy of the fimbria-fornix: a time course study
Regulation (profile) of ChAT in cholinergic neurons
18) Confidence 0.27 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2826326 Disease Relevance 0.32 Pain Relevance 0.21
Expression profile of ChAT and p75 immunopositive septal cholinergic neurons after axotomy of the fimbria-fornix: a time course study
Regulation (immunopositive) of ChAT in cholinergic neurons
19) Confidence 0.27 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2826326 Disease Relevance 0.31 Pain Relevance 0.21
Disruption of the connection between septal cholinergic cells and the hippocampus results in down-regulation of ChAT, but not neuronal death.
Regulation (regulation) of ChAT in neuronal associated with hippocampus and death
20) Confidence 0.27 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2826326 Disease Relevance 0.92 Pain Relevance 0.11

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