INT11948

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Context Info
Confidence 0.43
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 2.80
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Vip)
Anatomy Link Frequency
plasma 4
cervical lymph nodes 4
neurons 2
nucleus 2
Vip (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 5 99.88 Very High Very High Very High
dexamethasone 6 99.74 Very High Very High Very High
Neuropeptide 7 99.64 Very High Very High Very High
tetrodotoxin 2 99.56 Very High Very High Very High
Serotonin 7 96.12 Very High Very High Very High
anesthesia 3 91.92 High High
Pain 2 80.96 Quite High
nud 1 80.60 Quite High
antagonist 10 77.68 Quite High
fluoxetine 9 75.00 Quite High
Disease Link Frequency Relevance Heat
Aging 5 99.98 Very High Very High Very High
Pulmonary Hypertension 162 99.92 Very High Very High Very High
Systemic Sclerosis 24 97.36 Very High Very High Very High
Congenital Anomalies 4 94.12 High High
Injury 2 91.44 High High
Body Weight 2 90.84 High High
Arrhythmia Under Development 3 83.76 Quite High
Pain 2 80.96 Quite High
Dyspepsia 1 80.60 Quite High
Vomiting 1 79.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compared to the control group, FITC fluorescence of duodenal CRF expression and plasma CRF levels in the depressed rats increased significantly (fluorescence intensity of duodenal CRF: 11.82 +/- 2.54 vs 25.17 +/- 4.63; plasma CRF: 11.82 +/- 2.54 ng/L vs 25.17 +/- 4.63 ng/L, P < 0.01), whereas duodenal VIP expression and plasma VIP levels decreased significantly (fluorescence intensity of duodenal VIP: 67.37 +/- 18.90 vs 44.51 +/- 16.37; plasma VIP: 67.37 +/- 18.90 ng/L vs 44.51 +/- 16.37 ng/L, P < 0.01).
Negative_regulation (decreased) of Gene_expression (expression) of plasma VIP in plasma
1) Confidence 0.43 Published 2007 Journal World J. Gastroenterol. Section Body Doc Link 18023100 Disease Relevance 0.11 Pain Relevance 0
Our data show that expression of VIP is reduced in the nucleus that is deprived of retinal input.
Negative_regulation (reduced) of Gene_expression (expression) of VIP in nucleus
2) Confidence 0.38 Published 1992 Journal Brain Res. Section Abstract Doc Link 1611531 Disease Relevance 0 Pain Relevance 0.09
VIP biodistribution in cervical lymph nodes following an intravitreal injection of VIP-Rh-Lip
Negative_regulation (following) of Gene_expression (injection) of VIP-Rh-Lip in cervical lymph nodes
3) Confidence 0.37 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0 Pain Relevance 0
VIP biodistribution in cervical lymph nodes following an intravitreal injection of VIP-Rh-Lip
Negative_regulation (following) of Gene_expression (biodistribution) of VIP in cervical lymph nodes
4) Confidence 0.37 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0 Pain Relevance 0
NK-2-receptor agonists elicited only contraction that was not affected by tetrodotoxin; these agonists also inhibited VIP release, NO production, and relaxation induced by NK-1- and NK-3-receptor agonists.
Negative_regulation (inhibited) of Neg (NO) Gene_expression (production) of VIP associated with tetrodotoxin and agonist
5) Confidence 0.36 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 7682782 Disease Relevance 0 Pain Relevance 0.45
Correlations are also noted between plasma VIP/Motilin levels and gastric slow waves.
Negative_regulation (noted) of Gene_expression (levels) of plasma VIP in plasma
6) Confidence 0.22 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19566588 Disease Relevance 0.97 Pain Relevance 0.12
Administration of either the low or high dose of DEX to ADX rats prevented the appearance of the PVN-VIP neurons.
Negative_regulation (prevented) of Gene_expression (appearance) of PVN-VIP in neurons associated with dexamethasone
7) Confidence 0.15 Published 1990 Journal Regul. Pept. Section Abstract Doc Link 1974081 Disease Relevance 0.15 Pain Relevance 0.49
Aging decreases expression of mRNA for vasoactive intestinal peptide (VIP), a key neuropeptide for rhythm generation and photic phase shifts, and increases expression of serotonin transporters and 5-HT(1B) receptors, whose activation inhibits these phase shifts.
Negative_regulation (decreases) of Gene_expression (expression) of VIP associated with aging, neuropeptide and serotonin
8) Confidence 0.13 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20525077 Disease Relevance 0.26 Pain Relevance 0.39
Central to the development of PAH is reduced production of prostacyclin (PGI2), nitric oxide (NO) and vasoactive intestinal peptide (VIP), with upregulation of endothelin 1 (ET-1) (Humbert, Sitbon et al 2004).
Negative_regulation (reduced) of Gene_expression (production) of intestinal peptide associated with pulmonary hypertension
9) Confidence 0.03 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350123 Disease Relevance 1.31 Pain Relevance 0

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