INT119486

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Context Info
Confidence 0.23
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.96
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Grip2) plasma membrane (Grip2) cytoskeleton (Grip2)
cytoplasm (Grip2)
Anatomy Link Frequency
cerebral cortex 2
forebrain 2
Grip2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 258 100.00 Very High Very High Very High
cerebral cortex 26 100.00 Very High Very High Very High
Glutamate 48 98.08 Very High Very High Very High
Hippocampus 138 95.64 Very High Very High Very High
isoflurane 1 95.20 Very High Very High Very High
anesthesia 1 94.32 High High
agonist 29 89.60 High High
Glutamate receptor 16 88.96 High High
projection neuron 2 72.64 Quite High
depression 18 39.04 Quite Low
Disease Link Frequency Relevance Heat
Aging 228 93.52 High High
Sprains And Strains 14 81.60 Quite High
Depression 18 39.04 Quite Low
Cognitive Disorder 50 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 28 5.00 Very Low Very Low Very Low
Disease 16 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 6 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a result, the specific binding of (S)-[3H]-5-fluorowillardiine to AMPA receptors in the cerebral cortex decreased 46% from 2.7 +/- 0.3 to 1.5 +/- 0.6 (density units).
Negative_regulation (decreased) of AMPA Binding (binding) of in cerebral cortex associated with cerebral cortex
1) Confidence 0.23 Published 2004 Journal Neurochem. Res. Section Abstract Doc Link 15202775 Disease Relevance 0 Pain Relevance 0.40
Aged Wistar rats show a greater decline in MK801 binding to the NMDA receptor than AMPA binding in the forebrain (Ossowska et al., 2001).
Negative_regulation (decline) of AMPA Binding (binding) of in forebrain associated with nmda receptor
2) Confidence 0.01 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.37 Pain Relevance 0.48
In addition, the percent decrease in binding of [3H]AMPA in aged mice is always less than seen with [3H]glutamate binding to NMDA sites in these mice.
Negative_regulation (decrease) of AMPA Binding (binding) of associated with glutamate
3) Confidence 0.00 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.59 Pain Relevance 0.54

General Comments

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