INT119499

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Context Info
Confidence 0.11
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.80
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde6b)
Anatomy Link Frequency
neurons 2
Pde6b (Mus musculus)
Pain Link Frequency Relevance Heat
nav1.8 4 99.76 Very High Very High Very High
hyperexcitability 2 95.64 Very High Very High Very High
Neuronal excitability 1 82.20 Quite High
Inflammation 5 51.68 Quite High
IPN 1 44.08 Quite Low
Nav1.9 1 41.52 Quite Low
Neuropeptide 1 25.00 Low Low
nociceptor 1 25.00 Low Low
alcohol 3 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colitis 5 99.98 Very High Very High Very High
Disease 5 88.00 High High
Pulmonary Disease 5 87.04 High High
Hypertension 27 86.64 High High
Inflammatory Bowel Disease 1 52.24 Quite High
INFLAMMATION 4 49.72 Quite Low
Inflammatory Pain 1 44.08 Quite Low
Hypoxia 15 5.00 Very Low Very Low Very Low
Stress 7 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of gender hormones on the expression and activity of the de-nitrosylating enzyme S-nitrosoglutathione reductase (GSNO-R) are undefined.
Spec (undefined) Regulation (effects) of Positive_regulation (activity) of GSNO-R
1) Confidence 0.11 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2982841 Disease Relevance 0.35 Pain Relevance 0
Together, these findings suggest that colitis alters trkA-positive neurons to preferentially increase slow TTX-R Na+ (Nav1.8) currents.
Regulation (alters) of Positive_regulation (increase) of TTX-R in neurons associated with colitis and nav1.8
2) Confidence 0.02 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15205116 Disease Relevance 0.46 Pain Relevance 0.43

General Comments

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