INT119516

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Context Info
Confidence 0.21
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.81
Pain Relevance 2.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
RVM 2
brain 2
DRG 2
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 16 100.00 Very High Very High Very High
Rostral ventromedial medulla 7 100.00 Very High Very High Very High
Central grey 4 100.00 Very High Very High Very High
Spinal cord 1 99.92 Very High Very High Very High
allodynia 2 99.82 Very High Very High Very High
Inflammation 8 99.72 Very High Very High Very High
dorsal root ganglion 12 99.24 Very High Very High Very High
Nerve growth factor 4 98.14 Very High Very High Very High
Pain 10 95.00 High High
IPN 1 91.60 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 5 100.00 Very High Very High Very High
Neuropathic Pain 3 99.82 Very High Very High Very High
INFLAMMATION 8 99.72 Very High Very High Very High
Ganglion Cysts 12 99.24 Very High Very High Very High
Neurodegenerative Disease 4 95.12 Very High Very High Very High
Pain 7 95.00 High High
Inflammatory Pain 1 91.60 High High
Nociception 1 85.12 High High
Nerve Root Compression 1 64.00 Quite High
Depression 14 60.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lithium antagonizes phosphorylated CREB loss and upregulates both CREB and BDNF in several brain regions [118].
Positive_regulation (upregulates) of Phosphorylation (phosphorylated) of BDNF in brain associated with bdmf
1) Confidence 0.21 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.21 Pain Relevance 0.29
BDNF in PAG and TrkB phosphorylation in RVM neurons are upregulated after inflammation.
Positive_regulation (upregulated) of Phosphorylation (phosphorylation) of BDNF in RVM associated with inflammation, central grey and rostral ventromedial medulla
2) Confidence 0.19 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16399679 Disease Relevance 0.98 Pain Relevance 1.06
Furthermore, we found that nerve growth factor (NGF) injection directly into the L4/5 nerve roots and DRG produced mechanical allodynia, and an increase in the phosphorylation of ERK and BDNF expression in the DRG, but the mitogen-activated protein kinase (MAPK) kinase1/2 inhibitor, U0126, inhibited the effects induced by NGF.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of BDNF in DRG associated with dorsal root ganglion, allodynia and nerve growth factor
3) Confidence 0.07 Published 2004 Journal Neuroscience Section Abstract Doc Link 15207334 Disease Relevance 1.62 Pain Relevance 1.33

General Comments

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