INT119518

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.47
Pain Relevance 2.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NTRK1) endosome (NTRK1) plasma membrane (NTRK1)
Anatomy Link Frequency
DRG 2
NTRK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 24 100.00 Very High Very High Very High
allodynia 3 99.36 Very High Very High Very High
dorsal root ganglion 13 97.88 Very High Very High Very High
Inflammation 39 97.24 Very High Very High Very High
intrathecal 1 89.92 High High
Pain 8 88.24 High High
opioid receptor 110 86.16 High High
qutenza 68 78.84 Quite High
Morphine 53 77.40 Quite High
Opioid 18 75.04 Quite High
Disease Link Frequency Relevance Heat
Thyroid Neoplasm 161 100.00 Very High Very High Very High
Neuropathic Pain 7 99.36 Very High Very High Very High
Ganglion Cysts 21 97.88 Very High Very High Very High
Breast Cancer 1 97.88 Very High Very High Very High
Apoptosis 5 97.76 Very High Very High Very High
INFLAMMATION 38 97.24 Very High Very High Very High
Pancreatic Cancer 9 93.80 High High
Malignant Neoplastic Disease 5 93.32 High High
Prostate Cancer 5 92.48 High High
Manic Depressive Disorder 1 92.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, it has also been detected that high levels of TrkA expression have a more favorable overall survival prognosis in breast cancer patients, but the relationships between the two receptors according to the prognosis in pancreatic cancer patients are unknown.
Positive_regulation (levels) of Gene_expression (expression) of TrkA associated with pancreatic cancer and breast cancer
1) Confidence 0.67 Published 2005 Journal Oncol. Rep. Section Abstract Doc Link 15944784 Disease Relevance 0.71 Pain Relevance 0.24
While the DRG culture conditions utilised in our study included NGF and may therefore represent increased expression of TRPV1 in trk-A-expressing fibres, our findings are nonetheless relevant as increased NGF levels occur physiologically during inflammation [55].
Positive_regulation (increased) of Gene_expression (expressing) of trk-A associated with inflammation
2) Confidence 0.49 Published 2006 Journal Mol Pain Section Body Doc Link PMC1553434 Disease Relevance 0.19 Pain Relevance 1.02
The co-expression of both NGF receptors, p75(NGFR) and tropomyosin-related kinase A (trkA), represents a crucial condition for the antiproliferative effect of NGF; indeed, p75(NGFR) is progressively lost during prostate tumorigenesis and its disappearance represents a malignancy marker of prostate adenocarcinoma (PCa).
Positive_regulation (represents) of Gene_expression (co-expression) of trkA associated with malignant neoplastic disease, nerve growth factor and prostate cancer
3) Confidence 0.31 Published 2010 Journal Growth Factors Section Abstract Doc Link 20166899 Disease Relevance 0.65 Pain Relevance 0.38
Overexpression of the Notch1 intracellular domain in MTC
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of MTC associated with thyroid neoplasm
4) Confidence 0.10 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 0.43 Pain Relevance 0
Inflammation of the L4/5 nerve roots and DRG induced by complete Freund's adjuvant (CFA) produced mechanical allodynia on the ipsilateral hindpaw and induced an increase in the phosphorylation of ERK, mainly in tyrosine kinase (trk) A-expressing small- and medium-size neurons.
Positive_regulation (induced) of Gene_expression (expressing) of trk in DRG associated with dorsal root ganglion, allodynia and inflammation
5) Confidence 0.02 Published 2004 Journal Neuroscience Section Abstract Doc Link 15207334 Disease Relevance 1.49 Pain Relevance 1.02

General Comments

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