INT119519

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Context Info
Confidence 0.09
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.92
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TXK) nucleus (TXK) DNA binding (TXK)
cytoplasm (TXK)
Anatomy Link Frequency
DRG 2
TXK (Homo sapiens)
Pain Link Frequency Relevance Heat
allodynia 2 99.36 Very High Very High Very High
dorsal root ganglion 12 97.88 Very High Very High Very High
Inflammation 7 97.24 Very High Very High Very High
intrathecal 1 89.92 High High
Pain 4 88.24 High High
Nerve growth factor 4 67.76 Quite High
qutenza 1 36.28 Quite Low
Sciatica 3 25.00 Low Low
Neuropathic pain 1 25.00 Low Low
headache 3 18.32 Low Low
Disease Link Frequency Relevance Heat
Philadelphia Chromosome 2 99.52 Very High Very High Very High
Neuropathic Pain 3 99.36 Very High Very High Very High
Ganglion Cysts 12 97.88 Very High Very High Very High
INFLAMMATION 7 97.24 Very High Very High Very High
Genetic Translocation 1 96.92 Very High Very High Very High
Myeloid Leukemia 12 94.40 High High
Chronic Myeloid Leukemia 8 94.20 High High
Congenital Anomalies 1 92.52 High High
Pain 2 88.24 High High
Apoptosis 11 83.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
order to improve upon the current model of tyrosine kinase inhibition and its
Positive_regulation (upon) of Neg (inhibition) Gene_expression (inhibition) of tyrosine kinase
1) Confidence 0.09 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0.31 Pain Relevance 0
This gene directs the expression of a mutant, constitutively active tyrosine kinase called Bcr-Abl that activates a large number of proteins controlling cell cycle and inhibiting DNA repair, resulting in speeding up of cell division and incorporation of further genetic abnormalities [16].
Positive_regulation (directs) of Gene_expression (expression) of tyrosine kinase associated with congenital anomalies
2) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 1.12 Pain Relevance 0
Inflammation of the L4/5 nerve roots and DRG induced by complete Freund's adjuvant (CFA) produced mechanical allodynia on the ipsilateral hindpaw and induced an increase in the phosphorylation of ERK, mainly in tyrosine kinase (trk) A-expressing small- and medium-size neurons.
Positive_regulation (induced) of Gene_expression (expressing) of tyrosine kinase in DRG associated with dorsal root ganglion, allodynia and inflammation
3) Confidence 0.01 Published 2004 Journal Neuroscience Section Abstract Doc Link 15207334 Disease Relevance 1.49 Pain Relevance 1.02

General Comments

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