INT119520

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Context Info
Confidence 0.19
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 19
Total Number 20
Disease Relevance 17.54
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TXK) nucleus (TXK) DNA binding (TXK)
cytoplasm (TXK)
Anatomy Link Frequency
lung 2
endothelial cells 1
Hepatocyte 1
spinal cord 1
bone marrow 1
TXK (Homo sapiens)
Pain Link Frequency Relevance Heat
allodynia 2 98.14 Very High Very High Very High
Spinal cord 3 96.96 Very High Very High Very High
dorsal root ganglion 12 96.66 Very High Very High Very High
Inflammation 17 96.02 Very High Very High Very High
intrathecal 4 89.92 High High
headache 11 89.56 High High
Pain 13 85.80 High High
Central nervous system 46 84.72 Quite High
methotrexate 18 83.52 Quite High
Nerve growth factor 7 67.76 Quite High
Disease Link Frequency Relevance Heat
Endometriosis (extended) 13 100.00 Very High Very High Very High
Cancer 435 99.40 Very High Very High Very High
Adenoma 14 99.32 Very High Very High Very High
Philadelphia Chromosome 3 99.04 Very High Very High Very High
Breast Cancer 282 99.00 Very High Very High Very High
Leukemia 29 99.00 Very High Very High Very High
Gastrointestinal Stromal Tumor 79 98.94 Very High Very High Very High
Pituitary Cancer 16 98.92 Very High Very High Very High
Infection 67 98.60 Very High Very High Very High
Hepatitis C Virus Infection 117 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VEGR-1 and VEGFR-2 are high affinity transmembrane tyrosine kinase receptors selectively expressed by normal vascular and over-expressed in tumor endothelium (Dvorak 2002).
Gene_expression (expressed) of tyrosine kinase in endothelium associated with cancer
1) Confidence 0.19 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 0.71 Pain Relevance 0
EGFRThe human epidermal growth factor receptor (HER1/EGFR) is a transmembrane glycoprotein of the tyrosine kinase growth factor family that is expressed in many normal human tissues and several tumors such as colorectal (65–75%), head and neck (90%), and lung (60%–90%) carcinomas [8].
Gene_expression (expressed) of tyrosine kinase in lung associated with cancer and carcinoma
2) Confidence 0.14 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2699661 Disease Relevance 0.87 Pain Relevance 0
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) and guanylate kinase 1 (GUK1) are differentially expressed in GH-secreting adenomas.
Gene_expression (expressed) of tyrosine kinase in Hepatocyte associated with adenoma
3) Confidence 0.12 Published 2006 Journal Pituitary Section Title Doc Link 16832584 Disease Relevance 1.49 Pain Relevance 0.12
order to improve upon the current model of tyrosine kinase inhibition and its
Neg (inhibition) Gene_expression (inhibition) of tyrosine kinase
4) Confidence 0.11 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0.31 Pain Relevance 0
of Type I transmembrane tyrosine kinase receptors, which includes ErbB1/HER-1 (EGFR itself),
Gene_expression (receptors) of tyrosine kinase
5) Confidence 0.10 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0.40 Pain Relevance 0
We were able to identify several differentially expressed genes, among them hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) and guanylate kinase 1 (GUK1) which were over expressed in a pool of clinically nonfunctioning pituitary adenomas, compared with a spinal cord metastasis of a nonfunctioning pituitary carcinoma.
Gene_expression (expressed) of tyrosine kinase in spinal cord associated with pituitary cancer, metastasis and spinal cord
6) Confidence 0.10 Published 2006 Journal Pituitary Section Abstract Doc Link 16832584 Disease Relevance 1.69 Pain Relevance 0.13
EGF-R and HER-2 combined targeted tyrosine-kinase inhibitors
Gene_expression (combined) of tyrosine-kinase
7) Confidence 0.07 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2868849 Disease Relevance 0.20 Pain Relevance 0.08
As shown in figure 6, the expression of the tyrosine kinase receptor PDGFR ?
Gene_expression (expression) of tyrosine kinase
8) Confidence 0.06 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2925350 Disease Relevance 0.15 Pain Relevance 0
Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase frequently expressed in epithelial tumors.
Gene_expression (expressed) of tyrosine kinase associated with cancer
9) Confidence 0.06 Published 2010 Journal Breast Cancer Res Section Body Doc Link PMC2972555 Disease Relevance 0.72 Pain Relevance 0
Lapatinib, an orally active small molecule, inhibits the tyrosine kinase activity of both epidermal growth factor receptor (EGFR) and HER-2.
Gene_expression (activity) of tyrosine kinase
10) Confidence 0.05 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721345 Disease Relevance 0.72 Pain Relevance 0.08
In contrast, therapies targeting the HER2 receptor and HER2 tyrosine kinase have shown great clinical efficacy in this tumor subtype with a poor natural history.
Gene_expression (targeting) of tyrosine kinase associated with cancer
11) Confidence 0.04 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004582 Disease Relevance 0.90 Pain Relevance 0
EGFR tyrosine kinase inhibitors (TKIs) produce dramatic and durable responses in a fraction of non-small cell lung cancer patients [68–69].
Gene_expression (produce) of tyrosine kinase in lung associated with lung cancer
12) Confidence 0.04 Published 2007 Journal The Open Respiratory Medicine Journal Section Body Doc Link PMC2596356 Disease Relevance 0.86 Pain Relevance 0.03
ErbB2, perhaps the most studied member of the type I receptor tyrosine kinase family, is overexpressed in approximately 20% of breast cancer.
Gene_expression (overexpressed) of tyrosine kinase associated with breast cancer
13) Confidence 0.04 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004582 Disease Relevance 1.15 Pain Relevance 0
Its two shorter isoforms (VEGF121 and VEGF165) induce angiogenic effects by binding to the specific transmembrane tyrosine kinase receptors KDR/flk-1 and flt-1, respectively, which are expressed selectively on endothelial cells.
Gene_expression (expressed) of tyrosine kinase in endothelial cells
14) Confidence 0.02 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 0.93 Pain Relevance 0
This gene directs the expression of a mutant, constitutively active tyrosine kinase called Bcr-Abl that activates a large number of proteins controlling cell cycle and inhibiting DNA repair, resulting in speeding up of cell division and incorporation of further genetic abnormalities [16].
Gene_expression (expression) of tyrosine kinase associated with congenital anomalies
15) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 1.12 Pain Relevance 0
In addition to the modulation of bone marrow angiogenesis by leukemia cells, it was demonstrated that subsets of cases express endothelial-specific tyrosine kinase receptors, such as VEGFR-1, -2, and -3, or members of the FGF receptor family [49, 52, 53].
Gene_expression (express) of tyrosine kinase in bone marrow associated with leukemia
16) Confidence 0.02 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2875768 Disease Relevance 0.45 Pain Relevance 0
Inflammation of the L4/5 nerve roots and DRG induced by complete Freund's adjuvant (CFA) produced mechanical allodynia on the ipsilateral hindpaw and induced an increase in the phosphorylation of ERK, mainly in tyrosine kinase (trk) A-expressing small- and medium-size neurons.
Gene_expression (expressing) of tyrosine kinase in DRG associated with dorsal root ganglion, allodynia and inflammation
17) Confidence 0.02 Published 2004 Journal Neuroscience Section Abstract Doc Link 15207334 Disease Relevance 1.46 Pain Relevance 1.01
To investigate whether heroin use or heroin use plus HCV infection has an impact on IL-12 pathway in CD56+ T cells, the transcriptional expression of key elements [IL-12 receptors, signal transducer and activator of transcription (STAT)-1, 3, 4, 5, janus kinase (JAK)-2, and tyrosine kinase (TYK)-2] in IL-12 pathway in CD56+ T cells was analyzed by the real-time RT PCR.
Gene_expression (expression) of tyrosine kinase in T cells associated with hepatitis c virus infection, opiate addiction and infection
18) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 2.54 Pain Relevance 0
The diagnosis and treatment of GIST has been revolutionized over the past decade, since expression of the receptor tyrosine kinase KIT was shown to occur on these tumors.
Gene_expression (expression) of tyrosine kinase associated with cancer and gastrointestinal stromal tumor
19) Confidence 0.01 Published 2008 Journal Therapeutics and Clinical Risk Management Section Abstract Doc Link PMC2503651 Disease Relevance 0.70 Pain Relevance 0
Changes in estimated percentage breast density, oestradiol, FSH, LH, tyrosine kinase activity, menopausal symptom score, and number of hot flushes from baseline to 12 months were expressed as absolute change (i.e. 12-month data – baseline data).
Gene_expression (expressed) of tyrosine kinase associated with endometriosis (extended)
20) Confidence 0.01 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400670 Disease Relevance 0.18 Pain Relevance 0

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