INT119525

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 2001
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 5.15
Pain Relevance 8.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Camk2a) kinase activity (Camk2a) cytoplasm (Camk2a)
Anatomy Link Frequency
retina 4
ganglion cells 3
neurons 2
brain 2
forebrain 2
Camk2a (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 225 100.00 Very High Very High Very High
withdrawal 48 100.00 Very High Very High Very High
narcan 13 100.00 Very High Very High Very High
long-term potentiation 97 99.90 Very High Very High Very High
nMDA receptor antagonist 43 99.84 Very High Very High Very High
Kinase C 106 99.76 Very High Very High Very High
Glutamate 87 98.80 Very High Very High Very High
Anterior cingulate cortex 34 98.16 Very High Very High Very High
Pain 72 97.84 Very High Very High Very High
Nucleus accumbens 3 97.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 38 100.00 Very High Very High Very High
Opiate Addiction 7 100.00 Very High Very High Very High
Targeted Disruption 90 99.64 Very High Very High Very High
Injury 37 98.40 Very High Very High Very High
Pain 80 97.84 Very High Very High Very High
INFLAMMATION 21 92.48 High High
Urological Neuroanatomy 37 92.04 High High
Retina Disease 2 90.60 High High
Congenital Anomalies 3 90.44 High High
Depression 42 89.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While our results do not show a direct correlation between the loss of synaptic LTD in the ACC and a reduction in behavioral sensitization in CaMKII transgenic mice, we suggest that the enhanced forebrain CaMKII activity reduced behavioral sensitization to peripheral injury and that the synaptic function of CaMKII in cingulate neurons may be one mechanism contributing to this behavioral phenotype.
Negative_regulation (reduced) of Positive_regulation (enhanced) of CaMKII in neurons associated with targeted disruption, injury and anterior cingulate cortex
1) Confidence 0.43 Published 2006 Journal Mol Pain Section Body Doc Link PMC1513196 Disease Relevance 1.17 Pain Relevance 0.61
On the other hand, the suppression of sustained CaMKII activation largely depended on the duration of GABABR activation.
Negative_regulation (suppression) of Positive_regulation (activation) of CaMKII
2) Confidence 0.42 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0.35 Pain Relevance 0.13
Again, administration of LNNA or naltrindole before morphine prevented the phosphorylation of NMDAR subunits and the activation of CaMKII as well (Fig. 4).
Negative_regulation (prevented) of Positive_regulation (activation) of CaMKII associated with morphine
3) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 1.28
Antisense-pretreated mice showed decreased neurogranin expression, lack of morphine-induced phosphorylation of neurogranin and activation of CaMKII and CREB, and absence of naloxone-induced withdrawal jumping.
Negative_regulation (showed) of Positive_regulation (activation) of CaMKII associated with narcan, withdrawal and morphine
4) Confidence 0.41 Published 2007 Journal Brain Res. Section Abstract Doc Link 17306231 Disease Relevance 0.16 Pain Relevance 0.93
This up-regulation of p-CaMKII in the limbic forebrain obtained from morphine-conditioned mice was significantly inhibited by i.c.v. pretreatment with KN-93.
Negative_regulation (inhibited) of Positive_regulation (up-regulation) of p-CaMKII in forebrain associated with morphine
5) Confidence 0.37 Published 2004 Journal Neuroscience Section Abstract Doc Link 15207359 Disease Relevance 0.09 Pain Relevance 1.06
We have previously reported that retinal CaMKII mRNA, protein and enzyme activity (localized in the somas of amacrine cells and ganglion cells and in the inner plexifom layer) but not PKC?
Negative_regulation (retinal) of Neg (not) Positive_regulation (not) of CaMKII mRNA in ganglion cells associated with ganglion cysts
6) Confidence 0.37 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0.19 Pain Relevance 0.16
Targeted mutation of the EphB1 gene successfully prevented development of LTP and suppressed the associated activation (phosphorylation) of CaMKII, ERK, and CREB as well as increased c-Fos expression.
Negative_regulation (suppressed) of Positive_regulation (activation) of CaMKII associated with long-term potentiation
7) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0 Pain Relevance 0.40
To block activated CaMKII, we used KN-93 (5 ?
Negative_regulation (block) of Positive_regulation (activated) of CaMKII
8) Confidence 0.33 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.34 Pain Relevance 0.48
-agatoxin blocked the enhanced CaMKII activity.
Negative_regulation (blocked) of Positive_regulation (enhanced) of CaMKII
9) Confidence 0.33 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.16 Pain Relevance 0.12
During intervals of diminished NO production due to the loss of Akt activity and the action of CaMKII on nNOS, the zinc ions required for PKC?
Neg (NO) Negative_regulation (diminished) of Positive_regulation (action) of CaMKII associated with kinase c
10) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.66
The activation of CaMKII and increased expression of c-Fos protein in the brain of animals with naloxone-precipitated withdrawal syndrome are prevented by NMDA receptor antagonists, whereas the increased levels of extracellular glutamate are not prevented by them.
Negative_regulation (prevented) of Positive_regulation (activation) of CaMKII in brain associated with glutamate, nmda receptor antagonist, narcan and withdrawal
11) Confidence 0.24 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464026 Disease Relevance 0.67 Pain Relevance 1.54
In addition, the hippocampal slices of Ng knockout mice displayed a reduced activation of Ca2+/CaM-dependent kinase II (CaMKII) and PKC isozymes, as well as PKA.
Negative_regulation (reduced) of Positive_regulation (activation) of CaMKII associated with targeted disruption and kinase c
12) Confidence 0.19 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1865092 Disease Relevance 0.56 Pain Relevance 0.38
We have previously reported that retinal CaMKII mRNA, protein and enzyme activity (localized in the somas of amacrine cells and ganglion cells and in the inner plexifom layer) but not PKC?
Negative_regulation (retinal) of in amacrine cells Neg (not) Positive_regulation (not) of CaMKII mRNA in ganglion cells associated with ganglion cysts
13) Confidence 0.12 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0.19 Pain Relevance 0.16
A very high concentration of memantine (20 µM but not 500 µM) also blocked the increased levels of CaMKII subunits induced by intravitreal injection of glutamate in the adult rat retina [140].
Negative_regulation (blocked) of Positive_regulation (induced) of CaMKII in retina associated with glutamate
14) Confidence 0.09 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645549 Disease Relevance 0.65 Pain Relevance 0.29
A very high concentration of memantine (20 µM but not 500 µM) also blocked the increased levels of CaMKII subunits induced by intravitreal injection of glutamate in the adult rat retina [140].
Negative_regulation (blocked) of Positive_regulation (increased) of CaMKII in retina associated with glutamate
15) Confidence 0.09 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645549 Disease Relevance 0.64 Pain Relevance 0.26

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox