INT119526

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Context Info
Confidence 0.45
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.39
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Camk2a) kinase activity (Camk2a) cytoplasm (Camk2a)
Anatomy Link Frequency
trigeminal ganglia 2
spines 2
brain 2
hippocampus 2
Camk2a (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 8 100.00 Very High Very High Very High
midbrain 2 98.54 Very High Very High Very High
Hippocampus 11 96.60 Very High Very High Very High
Anterior cingulate cortex 34 94.72 High High
monoamine 13 93.28 High High
agonist 11 87.08 High High
opioid receptor 1 86.76 High High
cytokine 3 86.56 High High
antinociception 3 83.24 Quite High
Central nervous system 3 79.20 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 169 99.12 Very High Very High Very High
Urological Neuroanatomy 1 98.08 Very High Very High Very High
Congenital Anomalies 9 95.68 Very High Very High Very High
Schizophrenia 13 84.52 Quite High
Cognitive Disorder 12 50.60 Quite High
Depression 22 50.00 Quite Low
Ganglion Cysts 12 50.00 Quite Low
Neuropathic Pain 9 50.00 Quite Low
Migraine With Aura 5 50.00 Quite Low
Mental Disorders 4 40.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CaMKII overexpression selectively affected the frequency-response relationship of synaptic plasticity in the CA1 region of the hippocampus [16].
Regulation (affected) of Gene_expression (overexpression) of CaMKII in hippocampus associated with hippocampus
1) Confidence 0.45 Published 2006 Journal Mol Pain Section Body Doc Link PMC1513196 Disease Relevance 0.63 Pain Relevance 0.32
Immunoblotting performed on protein extracts from trigeminal ganglia and cultures further demonstrated that, despite the lack of change in total CaMKII level between WT and KI (n = 4, p > 0.05; Fig. 4B), the active fraction of CaMKII (T286-phosphorylated) was significantly larger in KI than WT (Fig. 4B; n = 4, p = 0.03).
Regulation (change) of Gene_expression (level) of CaMKII in trigeminal ganglia
2) Confidence 0.34 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0
Thus, the morphological changes observed in dendritic spines may have been a result of the observed decreases in the expression of the NR1, PSD-95, p-CaMKII, and PAK families.
Regulation (result) of Gene_expression (expression) of p-CaMKII in spines
3) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.66 Pain Relevance 0.19
The levels of phosphorylated-CaMKII (p-CaMKII) in the limbic forebrain, but not in the frontal cortex and the lower midbrain, were significantly increased in morphine-conditioned mice, whereas the levels of CaMKII in three brain regions obtained from morphine-conditioned mice were not changed.
Neg (not) Regulation (changed) of Gene_expression (levels) of CaMKII in brain associated with urological neuroanatomy, midbrain and morphine
4) Confidence 0.27 Published 2004 Journal Neuroscience Section Abstract Doc Link 15207359 Disease Relevance 0.10 Pain Relevance 1.06

General Comments

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