INT119540

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Context Info
Confidence 0.48
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 29
Total Number 29
Disease Relevance 6.34
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Nfe2l2) nucleus (Nfe2l2) DNA binding (Nfe2l2)
cytoplasm (Nfe2l2)
Anatomy Link Frequency
neuronal 1
fibroblast 1
Nfe2l2 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 22 98.76 Very High Very High Very High
withdrawal 1 98.68 Very High Very High Very High
anesthesia 1 97.00 Very High Very High Very High
Glutamate 7 95.84 Very High Very High Very High
metalloproteinase 1 93.00 High High
Paracetamol 39 86.72 High High
Migraine 1 86.04 High High
Central grey 1 65.68 Quite High
Inflammation 83 56.40 Quite High
antagonist 15 49.28 Quite Low
Disease Link Frequency Relevance Heat
Stress 470 99.32 Very High Very High Very High
Toxicity 107 98.96 Very High Very High Very High
Cancer 127 94.52 High High
Apoptosis 28 93.00 High High
Syndrome 8 90.24 High High
Chronic Disease 14 88.88 High High
Wound Healing 1 88.16 High High
Growth Problems 3 87.04 High High
Stroke 1 86.52 High High
Headache 1 86.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nrf2 binds antioxidant response elements (AREs) in the regulatory regions of target genes and activates transcription.
Nrf2 Binding (binds) of
1) Confidence 0.48 Published 2007 Journal Toxicol Pathol Section Abstract Doc Link 17562481 Disease Relevance 0.40 Pain Relevance 0.06
To test whether exogenous CRIF1 can affect NRF2 and NRF2 target gene mRNA levels when functional KEAP1-NRF2 interactions are eliminated, cells were infected with adenovirus (GFP versus GFP-CRIF1) (19) for 24 h and then treated with t-BHQ (100 ?
NRF2 Binding (interactions) of
2) Confidence 0.39 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0.06 Pain Relevance 0
Because CRIF1 and NRF2 interact, we tested whether CRIF1 can affect NRF2 protein levels under normal reducing conditions.
NRF2 Binding (interact) of
3) Confidence 0.39 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0 Pain Relevance 0
Because our study showed that knockdown of endogenous CRIF1 enhanced SFN-induced NRF2 total and nuclear expression (Fig. 3, C and D), we determined whether the induced nuclear NRF2 binds to an ARE-containing DNA sequence.
NRF2 Binding (binds) of
4) Confidence 0.39 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0 Pain Relevance 0
Two molecules of KEAP1 bind to two distinct sites in the N-terminal region of NRF2, the ETGE and DLG sites, which affect the KEAP1-NRF2 interaction and/or its physiological consequences (12–14).
NRF2 Binding (interaction) of
5) Confidence 0.39 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0.45 Pain Relevance 0.09
The major ARE-binding transcription factor is nuclear factor-erythroid 2-related factor 2 (Nrf2), which, through heteromeric interaction with the small Maf proteins, binds the ARE and initiates the de novo expression of detoxifying enzymes [11].
nuclear factor-erythroid 2-related factor 2 Binding (initiates) of
6) Confidence 0.36 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2929514 Disease Relevance 0.17 Pain Relevance 0.09
As far as we are aware, this association between ATP-citrate lyase and Nrf2 has not been shown previously.


Nrf2 Binding (association) of
7) Confidence 0.36 Published 2010 Journal Journal of Proteomics Section Body Doc Link PMC2891861 Disease Relevance 0.08 Pain Relevance 0
Using immunohistochemistry, we localized the transcription factors Nrf2, which regulates expression of antioxidant and detoxification protein, and c-Fos, a marker of neuronal activation.
Nrf2 Binding (localized) of in neuronal
8) Confidence 0.35 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15207916 Disease Relevance 0.45 Pain Relevance 0.27
By promoting the inactivation of Nrf2-keap1 complex and increased binding to no-1ARE, curcumin induces hemoxygenase activity.
Nrf2 Binding (binding) of
9) Confidence 0.35 Published 2008 Journal Annals of Indian Academy of Neurology Section Body Doc Link PMC2781139 Disease Relevance 0.47 Pain Relevance 0.05
SFN can also activate the Keap1/Nrf2 transcriptional factor complex that can bind to the antioxidant response element (ARE) and induce a series of detoxification enzymes.
Nrf2 Binding (bind) of
10) Confidence 0.35 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.32 Pain Relevance 0
SFN can also activate the Keap1/Nrf2 transcriptional factor complex that can bind to the antioxidant response element (ARE) and induce a series of detoxification enzymes.
Nrf2 Binding (complex) of
11) Confidence 0.35 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.32 Pain Relevance 0
In what cellular compartment(s) does CRIF1 have its effect(s) on NRF2 protein stability?
NRF2 Binding (effect) of
12) Confidence 0.30 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0.20 Pain Relevance 0
The t-BHQ treatment did not significantly affect the ability of GFP-NRF2 and FLAG-CRIF1 to co-immunoprecipitate (Fig. 1B).
NRF2 Neg (not) Binding (ability) of
13) Confidence 0.30 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0.19 Pain Relevance 0
Our results also suggest a crosstalk between Nrf2/Keap1 and NF-?
Nrf2 Binding (crosstalk) of
14) Confidence 0.30 Published 2010 Journal Biochemical Pharmacology Section Body Doc Link PMC2884179 Disease Relevance 0.39 Pain Relevance 0
More work is required to fully define the emerging links between the Nrf2/Keap1 and NF-?
Nrf2 Binding (links) of
15) Confidence 0.30 Published 2010 Journal Biochemical Pharmacology Section Body Doc Link PMC2884179 Disease Relevance 0.35 Pain Relevance 0
The results of this study, indicating crosstalk between the Nrf2 and NF-?
Nrf2 Binding (crosstalk) of
16) Confidence 0.30 Published 2010 Journal Biochemical Pharmacology Section Body Doc Link PMC2884179 Disease Relevance 0.30 Pain Relevance 0
Comparison of Nrf2 and NF-?
Nrf2 Binding (Comparison) of
17) Confidence 0.30 Published 2010 Journal Biochemical Pharmacology Section Body Doc Link PMC2884179 Disease Relevance 0.10 Pain Relevance 0
NAPQI (Fig. 4A) and DNCB (Fig. 4B), which can covalently bind proteins and deplete GSH, increased Nrf2 activity and decreased NF-?
Nrf2 Binding (activity) of
18) Confidence 0.30 Published 2010 Journal Biochemical Pharmacology Section Body Doc Link PMC2884179 Disease Relevance 0.09 Pain Relevance 0
Thus far, CRIF1 with a molecular mass of 30 kDa has been reported (18); however, using the anti-CRIF1 mouse monoclonal antibody that we developed, we found that there are two distinguishable molecular masses of CRIF1 proteins, and the slower migrating form predominantly interacts with NRF2.
NRF2 Binding (interacts) of
19) Confidence 0.29 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0.13 Pain Relevance 0
Previously, it has been shown that NRF2 protein levels increase after oxidative stress because its negative regulator, KEAP1, loses its ability to bind NRF2 and cause its proteasome-mediated degradation during oxidative stress.
NRF2 Binding (bind) of associated with stress
20) Confidence 0.29 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2898415 Disease Relevance 0.44 Pain Relevance 0

General Comments

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