INT119541

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Context Info
Confidence 0.58
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 6.07
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ttr) extracellular space (Ttr) extracellular region (Ttr)
Ttr (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 10 96.44 Very High Very High Very High
Central grey 2 85.96 High High
Hippocampus 96 83.68 Quite High
withdrawal 2 65.12 Quite High
anesthesia 8 63.44 Quite High
Inflammation 28 59.60 Quite High
Migraine 2 52.48 Quite High
Central nervous system 10 34.88 Quite Low
chemokine 6 5.00 Very Low Very Low Very Low
Peripheral nervous system 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 36 100.00 Very High Very High Very High
Shock 20 100.00 Very High Very High Very High
Disease 36 99.84 Very High Very High Very High
Amyloid Plaque 24 98.80 Very High Very High Very High
Aging 202 97.72 Very High Very High Very High
Apoptosis 8 95.92 Very High Very High Very High
Sprains And Strains 248 89.04 High High
Alzheimer's Dementia 64 87.48 High High
Urological Neuroanatomy 2 85.96 High High
Familial Amyloidotic Polyneuropathy 42 78.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upregulation of oxidative stress induced (OSI) protein, heat shock protein (HSP) 84 and transthyretin (TTR) precursor in the oligemia group was confirmed with RT-PCR.
Positive_regulation (Upregulation) of transthyretin associated with stress and shock
1) Confidence 0.58 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15207916 Disease Relevance 0.62 Pain Relevance 0.19
The senescence-prone mice also demonstrated differential expression of some genes known to be involved in human diseases: these include transthyretin (Ttr) and Kcnq2, both of which show decreased levels of expression in S8 and S10.
Positive_regulation (include) of transthyretin associated with aging and disease
2) Confidence 0.46 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175968 Disease Relevance 1.51 Pain Relevance 0.04
The senescence-prone mice also demonstrated differential expression of some genes known to be involved in human diseases: these include transthyretin (Ttr) and Kcnq2, both of which show decreased levels of expression in S8 and S10.
Positive_regulation (include) of Ttr associated with aging and disease
3) Confidence 0.46 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175968 Disease Relevance 1.51 Pain Relevance 0.04
Upregulation of oxidative stress induced (OSI) protein, heat shock protein (HSP) 84 and transthyretin (TTR) precursor in the oligemia group was confirmed with RT-PCR.
Positive_regulation (Upregulation) of TTR associated with stress and shock
4) Confidence 0.44 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15207916 Disease Relevance 0.62 Pain Relevance 0.19
It has been suggested that a possible mechanism for TTR extracellular aggregation is the influence of secreted metabolites generated by oxidative stress and apoptosis on TTR aggregation [12].
Spec (possible) Positive_regulation (mechanism) of TTR associated with stress and apoptosis
5) Confidence 0.41 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 0.90 Pain Relevance 0.09
CSPG, previously established to be elevated in the TTR model in old mice presenting amyloid deposits [11], was now evaluated in the context of the combined doxycycline/TUDCA treatment.
Positive_regulation (elevated) of TTR associated with amyloid plaque
6) Confidence 0.38 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 0.92 Pain Relevance 0.05

General Comments

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