INT119543

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Context Info
Confidence 0.74
First Reported 2004
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 5.14
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ttr) extracellular space (Ttr) extracellular region (Ttr)
Anatomy Link Frequency
esophagus 1
brain 1
peripheral nervous system 1
synapse 1
intestine 1
Ttr (Mus musculus)
Ttr - V30M (1)
Pain Link Frequency Relevance Heat
Peripheral nervous system 16 87.28 High High
Central grey 1 79.12 Quite High
withdrawal 1 58.28 Quite High
anesthesia 9 56.60 Quite High
Inflammation 121 56.48 Quite High
Migraine 1 45.64 Quite Low
metalloproteinase 42 34.64 Quite Low
sodium channel 2 32.08 Quite Low
imagery 13 31.56 Quite Low
Pain 9 21.96 Low Low
Disease Link Frequency Relevance Heat
Familial Amyloidotic Polyneuropathy 168 99.44 Very High Very High Very High
Shock 19 97.92 Very High Very High Very High
Death 35 97.76 Very High Very High Very High
Stress 96 97.16 Very High Very High Very High
Alzheimer's Dementia 300 95.92 Very High Very High Very High
Disease 221 95.72 Very High Very High Very High
Targeted Disruption 80 93.68 High High
Amyloid Plaque 101 89.72 High High
Urological Neuroanatomy 2 79.12 Quite High
Amyloidosis 8 61.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of HSP 84, transthyretin precursor, and OSI genes adds further evidence that oligemia induces an oxidative stress response in the brain.
Gene_expression (expression) of transthyretin in brain associated with stress
1) Confidence 0.74 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15207916 Disease Relevance 0.53 Pain Relevance 0.13
Recent data demonstrated clearly activation of the classical UPR pathways in FAP tissues not specialized in TTR synthesis but presenting extracellular TTR aggregate and fibril deposition [14].
Gene_expression (synthesis) of TTR associated with familial amyloidotic polyneuropathy
2) Confidence 0.72 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 0.51 Pain Relevance 0
This cycle was repeated twice; then tissues were analyzed for TTR deposition as well as for other FAP markers related to ECM remodeling, oxidative stress, cellular death, and ER stress, and compared with age-matched non-treated or single treated animals (either with doxycycline or TUDCA).
Spec (analyzed) Gene_expression (deposition) of TTR associated with stress, familial amyloidotic polyneuropathy and death
3) Confidence 0.63 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 0.91 Pain Relevance 0
Figure 3 displays representative images of the results obtained and clearly shows that TTR deposition is significantly decreased in mice submitted to the high doxycycline/TUDCA dose combined treatment.
Gene_expression (deposition) of TTR
4) Confidence 0.63 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 0.48 Pain Relevance 0
Mice expressing human TTR V30M in a TTR null background heterozygous for the heat shock transcription factor 1 (Hsf1), thereafter referred to as the TTR/HSF mice model, were recently characterized and shown to have early non-fibrillar TTR deposition as compared to TTR mice, evolving to amyloid deposits in several organs and tissues including the peripheral nervous system [5].
Gene_expression (expressing) of TTR V30M (V30M) in peripheral nervous system associated with peripheral nervous system, shock and amyloid plaque
5) Confidence 0.56 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 0.43 Pain Relevance 0.04
Analysis of other organs with characteristic TTR deposition, such as esophagus and intestine, revealed the same pattern, i.e., individual treatments with either doxycycline or TUDCA were not effective at lowering these markers, whereas the combined treatment was (not shown).
Gene_expression (deposition) of TTR in intestine
6) Confidence 0.55 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 0.20 Pain Relevance 0
As TUDCA is effective in reducing TTR load in young TTR mice, in this work we also explored the potential of two drugs, doxycycline and TUDCA, and found a synergistic effect as combined cycled administration of both drugs was clearly beneficial to lower TTR deposition and all the biomarkers under study, whereas single individual drug administration failed to produce improvement of all of the markers evaluated.
Gene_expression (load) of TTR
7) Confidence 0.55 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 0.46 Pain Relevance 0
As TUDCA is effective in reducing TTR load in young TTR mice, in this work we also explored the potential of two drugs, doxycycline and TUDCA, and found a synergistic effect as combined cycled administration of both drugs was clearly beneficial to lower TTR deposition and all the biomarkers under study, whereas single individual drug administration failed to produce improvement of all of the markers evaluated.
Gene_expression (deposition) of TTR
8) Confidence 0.55 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 0.55 Pain Relevance 0
Analysis of other organs with characteristic TTR deposition, such as esophagus and intestine, revealed the same pattern, i.e., individual treatments with either doxycycline or TUDCA were not effective at lowering these markers, whereas the combined treatment was (not shown).
Gene_expression (deposition) of TTR in esophagus
9) Confidence 0.19 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 0.20 Pain Relevance 0
can rescue gene expression of transthyretin and Klotho, which is decreased in APP/APLP2 deficient mice, but cannot rescue the lethality and neuromuscular synapse defects of these mice, suggesting a gene expression regulation function for sAPP?
Gene_expression (expression) of transthyretin in synapse
10) Confidence 0.11 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.33 Pain Relevance 0
Fish oil has also been reported to increase the expression of transthyretin, which is an A?
Gene_expression (expression) of transthyretin
11) Confidence 0.08 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2876259 Disease Relevance 0.55 Pain Relevance 0.05

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