INT119544

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Context Info
Confidence 0.77
First Reported 2004
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 50
Total Number 67
Disease Relevance 19.32
Pain Relevance 4.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Nfe2l2) nucleus (Nfe2l2) DNA binding (Nfe2l2)
cytoplasm (Nfe2l2)
Anatomy Link Frequency
hepatocytes 2
embryonic death 2
embryonic kidney 2
poly 1
Hepa-1c1c7 1
Nfe2l2 (Mus musculus)
Pain Link Frequency Relevance Heat
Antinociceptive 18 99.80 Very High Very High Very High
Analgesic 26 99.64 Very High Very High Very High
qutenza 11 97.96 Very High Very High Very High
Glutamate 35 97.04 Very High Very High Very High
Migraine 2 96.08 Very High Very High Very High
Pain 13 95.68 Very High Very High Very High
Morphine 1 93.88 High High
Paracetamol 151 93.80 High High
fibrosis 1 93.36 High High
Inflammatory response 42 92.80 High High
Disease Link Frequency Relevance Heat
Toxicity 441 100.00 Very High Very High Very High
Targeted Disruption 292 100.00 Very High Very High Very High
Stress 1019 99.40 Very High Very High Very High
Apoptosis 67 98.88 Very High Very High Very High
Death 86 98.68 Very High Very High Very High
Shock 11 96.36 Very High Very High Very High
Cancer 135 96.20 Very High Very High Very High
Headache 2 96.08 Very High Very High Very High
Pain 1 95.68 Very High Very High Very High
Stroke 2 95.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, exposure of wild-type C57BL/6x129 Sv mice to nimesulide (100 mg/kg/day, po, for 5 days) was associated with nuclear translocation of immunoreactive Nrf2 in a small number of hepatocytes and induced >2-fold the expression levels of the Nrf2-target gene Nqo1 in wild-type but not Nrf2-null mice.
Gene_expression (expression) of Nrf2 in hepatocytes
1) Confidence 0.77 Published 2010 Journal Chem. Res. Toxicol. Section Abstract Doc Link 20405857 Disease Relevance 0.64 Pain Relevance 0
We demonstrate that Keap1/Nrf2 and NF-kappaB respond differently to electrophiles that bind proteins covalently and the redox perturbation associated with glutathione depletion, and that crosstalk may enable NF-kappaB to partly influence Nrf2 expression during cellular stress.
Gene_expression (expression) of Nrf2 associated with stress
2) Confidence 0.74 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20416283 Disease Relevance 0.40 Pain Relevance 0.09
Haeme oxygenase-1 overexpression via nAChRs and the transcription factor Nrf2 has antinociceptive effects in the formalin test.
Gene_expression (overexpression) of Nrf2 associated with analgesic and antinociceptive
3) Confidence 0.72 Published 2009 Journal Pain Section Title Doc Link 19660867 Disease Relevance 0.31 Pain Relevance 0.49
OA treatment dramatically increased expression of hepatic metallothionein (Mt), and increased the expression of the nuclear factor E2-related factor 2 (Nrf2), NAD(P)H:quinone oxidoreductase 1 (Nqo1), heme oxygenase-1 (Hmox1), and glutamate-cysteine ligases (Gclc and Gclm).
Gene_expression (expression) of nuclear factor E2-related factor 2 associated with glutamate
4) Confidence 0.71 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18706400 Disease Relevance 0 Pain Relevance 0.12
OA treatment dramatically increased expression of hepatic metallothionein (Mt), and increased the expression of the nuclear factor E2-related factor 2 (Nrf2), NAD(P)H:quinone oxidoreductase 1 (Nqo1), heme oxygenase-1 (Hmox1), and glutamate-cysteine ligases (Gclc and Gclm).
Gene_expression (expression) of Nrf2 associated with glutamate
5) Confidence 0.71 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18706400 Disease Relevance 0 Pain Relevance 0.12
The higher sensitivity of Nrf2 knockout mice to chemical toxicity is due in part to reduced basal and inducible expression of detoxification enzymes.
Gene_expression (expression) of Nrf2 associated with targeted disruption and toxicity
6) Confidence 0.68 Published 2007 Journal Toxicol Pathol Section Abstract Doc Link 17562481 Disease Relevance 1.16 Pain Relevance 0.14
Similarly, exposure of wild-type C57BL/6x129 Sv mice to nimesulide (100 mg/kg/day, po, for 5 days) was associated with nuclear translocation of immunoreactive Nrf2 in a small number of hepatocytes and induced >2-fold the expression levels of the Nrf2-target gene Nqo1 in wild-type but not Nrf2-null mice.
Gene_expression (expression) of Nrf2-null in hepatocytes
7) Confidence 0.67 Published 2010 Journal Chem. Res. Toxicol. Section Abstract Doc Link 20405857 Disease Relevance 0.65 Pain Relevance 0
CoPP-induced HO-1 expression in Nrf2 knockout mice was lost and correlated with the loss of antinociceptive effects.
Gene_expression (expression) of Nrf2 associated with targeted disruption and antinociceptive
8) Confidence 0.64 Published 2008 Journal Pain Section Abstract Doc Link 17964723 Disease Relevance 0.56 Pain Relevance 0.36
Human embryonic kidney (HEK) 293T cells treated with 10 microM CoPP expressed 20-fold higher HO-1 levels when compared to controls; this effect was suppressed by transfection with the dominant negative for the nuclear factor-erythroid 2-related factor 2 (Nrf2).
Gene_expression (transfection) of nuclear factor-erythroid 2-related factor 2 in embryonic kidney
9) Confidence 0.64 Published 2008 Journal Pain Section Abstract Doc Link 17964723 Disease Relevance 0.53 Pain Relevance 0.17
Human embryonic kidney (HEK) 293T cells treated with 10 microM CoPP expressed 20-fold higher HO-1 levels when compared to controls; this effect was suppressed by transfection with the dominant negative for the nuclear factor-erythroid 2-related factor 2 (Nrf2).
Gene_expression (transfection) of Nrf2 in embryonic kidney
10) Confidence 0.64 Published 2008 Journal Pain Section Abstract Doc Link 17964723 Disease Relevance 0.53 Pain Relevance 0.17
Response of the brain to oligemia: gene expression, c-Fos, and Nrf2 localization.
Gene_expression (expression) of Nrf2 in brain
11) Confidence 0.64 Published 2004 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 15207916 Disease Relevance 0.47 Pain Relevance 0.25
Nrf2 was found only in oligemia mice and was localized in neurons of the cingulate cortex and cerebellar Purkinje cells.
Gene_expression (found) of Nrf2 in cingulate cortex
12) Confidence 0.64 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15207916 Disease Relevance 0.46 Pain Relevance 0.25
As expected, we found that endogenous CRIF1 knockdown allowed modest but statistically significant increased reporter activity after NRF2 overexpression and after t-BHQ exposure (Fig. 7A) as compared with cells containing normal amounts of CRIF1.
Gene_expression (overexpression) of NRF2
13) Confidence 0.63 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0 Pain Relevance 0
We hypothesized that CRIF1 could negatively regulate NRF2 target gene expression at the chromosomal level by affecting NRF2 accumulation at ARE-containing regions of NRF2 target gene promoters and enhancers.
Gene_expression (expression) of NRF2
14) Confidence 0.63 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0 Pain Relevance 0
These results shown in Fig. 6 indicate that NRF2 target gene expression might be negatively regulated by CRIF1 protein levels under both oxidative stress and normal reducing conditions.
Gene_expression (expression) of NRF2 associated with stress
15) Confidence 0.63 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0.33 Pain Relevance 0
Thus, Keap1 knock-out mice die shortly after birth (possibly from uncontrolled expression of Nrf2 target genes), but mice defective for both Keap1 and Nrf2 are viable (possibly because Nrf2 target genes cannot be overexpressed sufficiently to cause embryonic death in the double knock-out).
Neg (cannot) Gene_expression (overexpressed) of Nrf2 in embryonic death associated with targeted disruption and death
16) Confidence 0.63 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0.89 Pain Relevance 0
Thus, Keap1 knock-out mice die shortly after birth (possibly from uncontrolled expression of Nrf2 target genes), but mice defective for both Keap1 and Nrf2 are viable (possibly because Nrf2 target genes cannot be overexpressed sufficiently to cause embryonic death in the double knock-out).
Gene_expression (expression) of Nrf2 in embryonic death associated with targeted disruption and death
17) Confidence 0.63 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0.76 Pain Relevance 0
However, under these conditions, this AP-1 mutant did not limit the ability of overexpressed NRF2 (Fig. 6B, middle panel) to induce reporter activity, but it may somewhat limit the capacity of t-BHQ treatment to induce reporter activity (Fig. 6C, middle panel).
Gene_expression (overexpressed) of NRF2
18) Confidence 0.63 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0.15 Pain Relevance 0
Next, we identified sites in the HO-1 enhancer necessary for maximal reporter plasmid induction under either reducing (NRF2 overexpression) or oxidative stress-inducing conditions (t-BHQ) (Fig. 6).
Gene_expression (overexpression) of NRF2 associated with stress
19) Confidence 0.63 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0.24 Pain Relevance 0
To determine the effects of endogenous CRIF1 protein levels on NRF2 target gene expression, we reduced endogenous CRIF1 protein levels with two CRIF1-specific siRNAs.
Gene_expression (expression) of NRF2
20) Confidence 0.63 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0 Pain Relevance 0

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