INT1196

Context Info Confidence 0.70 First Reported 1975 Last Reported 2010 Negated 5 Speculated 1 Reported most in Abstract Documents 51 Total Number 52 Disease Relevance 15.99 Pain Relevance 28.58

small molecule metabolic process (POMC) cell-cell signaling (POMC) cytoplasm (POMC) extracellular space (POMC) generation of precursor metabolites and energy (POMC) signal transduction (POMC)

Anatomy Link Frequency plasma 27 cerebrospinal fluid 6 pituitary 4 epidermis 4 anterior pituitary 3 POMC (Homo sapiens) POMC - A2M (1)

Pain Link Frequency Relevance Heat Enkephalin 116 100.00 Opioid 49 100.00 melanocortin 1 receptor 6 100.00 Acupuncture 13 99.98 cINOD 1 99.98 Morphine 38 99.78 Serotonin 17 99.78 agonist 19 99.60 narcan 43 99.56 cocaine 11 99.14

Disease Link Frequency Relevance Heat Stress 42 100.00 Fetal Distress 5 100.00 INFLAMMATION 25 99.88 Disease 15 99.12 Carcinoid 5 99.00 Hypertension 10 98.24 Body Weight 1 97.52 Cancer 25 97.40 Headache Disorders 5 97.28 Hypoglycemia 1 97.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Surgery induced a large increase in plasma ACTH in group I (no CORT, no FENT); the mean plasma ACTH level was 57 +/- 14 (+/- SE) pmol/L 10 min after the start of surgery, and it peaked at 92 +/- 18 pmol/L 50 min after the start of surgery.

Positive_regulation (induced) of Positive_regulation (increase) of ACTH in plasma

1) Confidence 0.70 Published 1988 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2848053 Disease Relevance 0 Pain Relevance 0.22

RESULTS: A biphasic effect of ethanol on beta-endorphin release was found, with low to medium (1.2, 1.6, and 2.0 g) but not high (2.4 g) doses of ethanol, inducing a significant increase in the dialysate content of beta-endorphin.

Positive_regulation (inducing) of Positive_regulation (increase) of beta-endorphin

2) Confidence 0.68 Published 2009 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 19302084 Disease Relevance 0 Pain Relevance 0

The increase in ACTH was enhanced following naloxone.

Positive_regulation (enhanced) of Positive_regulation (increase) of ACTH associated with narcan

3) Confidence 0.62 Published 1987 Journal Acta Endocrinol. Section Abstract Doc Link 3035849 Disease Relevance 0 Pain Relevance 0.50

In the present study, however, the concentration of immunoreactive beta-endorphin-like material (eight patients) or leu-enkephalin (four patients) did not increase in cerebrospinal fluid of patients 5 min after induction of anesthesia with thiopental, 2-5 mg/kg and N2O 70%; after an additional 10 min, during which halothane was added; at 5, 15, and 60 min after surgical incision; or after 30 min in the recovery room.

Positive_regulation (concentration) of Positive_regulation (immunoreactive) of beta-endorphin in cerebrospinal fluid associated with anesthesia, halothane and enkephalin

4) Confidence 0.50 Published 1984 Journal Anesthesiology Section Abstract Doc Link 6318607 Disease Relevance 0.09 Pain Relevance 0.65

In the present study, however, the concentration of immunoreactive beta-endorphin-like material (eight patients) or leu-enkephalin (four patients) did not increase in cerebrospinal fluid of patients 5 min after induction of anesthesia with thiopental, 2-5 mg/kg and N2O 70%; after an additional 10 min, during which halothane was added; at 5, 15, and 60 min after surgical incision; or after 30 min in the recovery room.

Neg (not) Positive_regulation (increase) of Positive_regulation (concentration) of beta-endorphin in cerebrospinal fluid associated with anesthesia, halothane and enkephalin

5) Confidence 0.50 Published 1984 Journal Anesthesiology Section Abstract Doc Link 6318607 Disease Relevance 0.09 Pain Relevance 0.66

Parallel in vivo and in vitro studies indicate that nonsteroidal anti-inflammatory drug potentiation of endorphin release is mediated at the level of the pituitary corticotroph cell.

Positive_regulation (mediated) of Positive_regulation (potentiation) of endorphin in corticotroph associated with inflammation and cinod

6) Confidence 0.50 Published 1997 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 9246021 Disease Relevance 0.40 Pain Relevance 0.18

The enhancement of NK activity with beta-endorphin increased at all E:T ratios tested.

Positive_regulation (increased) of Positive_regulation (enhancement) of beta-endorphin

7) Confidence 0.50 Published 1983 Journal J. Immunol. Section Abstract Doc Link 6300232 Disease Relevance 0 Pain Relevance 0.68

The authors conclude that the reaction of the beta-endorphin system to acupuncture (sensory peripheral) stimulation in humans did not involve pituitary hypersecretion, and suggest that the increase of beta-endorphin binding to the tissue receptor sites seems to be responsible for the peripheral (plasma) B-EPLI decrease after acupuncture.

Spec (seems) Positive_regulation (responsible) of Positive_regulation (increase) of beta-endorphin in plasma associated with acupuncture

8) Confidence 0.50 Published 1983 Journal Acupunct Electrother Res Section Abstract Doc Link 6138943 Disease Relevance 0 Pain Relevance 0.73

On the basis of these and previous data it seems likely that the amnesic effect of ACTH and epinephrine could be mediated by endogenous beta-endorphin release.

Positive_regulation (mediated) of Positive_regulation (effect) of ACTH

9) Confidence 0.50 Published 1983 Journal Psychoneuroendocrinology Section Abstract Doc Link 6308701 Disease Relevance 0.23 Pain Relevance 0.24

Exercise induced a slight but significant increase in plasma concentrations of both ACTH (32% increase) and beta-endorphin (60% increase) in group A.

Positive_regulation (induced) of Positive_regulation (increase) of ACTH in plasma

10) Confidence 0.50 Published 1992 Journal Psychiatry Res Section Abstract Doc Link 1315442 Disease Relevance 0.30 Pain Relevance 0.07

Exercise induced a slight but significant increase in plasma concentrations of both ACTH (32% increase) and beta-endorphin (60% increase) in group A.

Positive_regulation (induced) of Positive_regulation (increase) of beta-endorphin in plasma

11) Confidence 0.50 Published 1992 Journal Psychiatry Res Section Abstract Doc Link 1315442 Disease Relevance 0.30 Pain Relevance 0.07

In normal subjects, the hCRH-induced ACTH, beta-endorphin, and cortisol increases were almost completely abolished by pretreatment with FK 33-824.

Positive_regulation (increases) of Positive_regulation (hCRH-induced) of ACTH

12) Confidence 0.50 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3023423 Disease Relevance 0.50 Pain Relevance 0.30

In normal subjects, the hCRH-induced ACTH, beta-endorphin, and cortisol increases were almost completely abolished by pretreatment with FK 33-824.

Positive_regulation (increases) of Positive_regulation (hCRH-induced) of beta-endorphin

13) Confidence 0.50 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3023423 Disease Relevance 0.50 Pain Relevance 0.30

Solar-simulated ultraviolet radiation-induced upregulation of the melanocortin-1 receptor, proopiomelanocortin, and alpha-melanocyte-stimulating hormone in human epidermis in vivo.

Positive_regulation (radiation-induced) of Positive_regulation (upregulation) of alpha-melanocyte-stimulating hormone in epidermis associated with melanocortin 1 receptor

14) Confidence 0.50 Published 2004 Journal J. Invest. Dermatol. Section Title Doc Link 15009732 Disease Relevance 0.39 Pain Relevance 0.30

DEX pretreatment dose dependently suppressed the restraint stress-induced increased plasma ACTH concentration.

Positive_regulation (stress-induced) of Positive_regulation (increased) of ACTH in plasma associated with stress and dexamethasone

15) Confidence 0.50 Published 2003 Journal Neuroendocrinology Section Abstract Doc Link 14688444 Disease Relevance 0.99 Pain Relevance 0.74

Acute cocaine administration (30 mg i.v.) significantly increased ACTH mean peak amplitude (P < .05), mean percent increase in peak amplitude, (P < .05), mean peak area (P < .04), total peak area (P < .04) and incremental peak height (P < .04).

Positive_regulation (increased) of Positive_regulation (increased) of ACTH associated with cocaine

16) Confidence 0.49 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932162 Disease Relevance 0.07 Pain Relevance 0.53

In the human, haloperidol increased concentrations of beta-endorphin after both 24 h and chronic treatment, while cholecystokinin was never affected.

Positive_regulation (increased) of Positive_regulation (concentrations) of beta-endorphin associated with cholecystokinin

17) Confidence 0.49 Published 1990 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 2143059 Disease Relevance 0 Pain Relevance 0.72

In rat, the serotonin receptor antagonist metergoline decreased basal concentrations of the opioid peptide and blocked the increase of beta-endorphin concentrations induced by the serotonin precursor 5-hydroxytryptophan and the tricyclic antidepressant chlorimipramine.

Positive_regulation (increase) of Positive_regulation (induced) of beta-endorphin associated with antagonist, tricyclic antidepressant, opioid and serotonin

18) Confidence 0.49 Published 1990 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 2143059 Disease Relevance 0 Pain Relevance 0.68

These results indicate the co-existence of Met-enkephalin, Leu-enkephalin, Met-enkephalin-Arg-Gly-Leu and Met-enkephalin-Arg-Phe in human phaeochromocytomas, suggesting the preservation of amino acid sequences of these four opioid peptides even in neoplastic tissues.

Positive_regulation (indicate) of Positive_regulation (co-existence) of Met-enkephalin associated with enkephalin and opioid

19) Confidence 0.47 Published 1984 Journal Acta Endocrinol. Section Abstract Doc Link 6495993 Disease Relevance 0.07 Pain Relevance 2.32

These results indicate the co-existence of Met-enkephalin, Leu-enkephalin, Met-enkephalin-Arg-Gly-Leu and Met-enkephalin-Arg-Phe in human phaeochromocytomas, suggesting the preservation of amino acid sequences of these four opioid peptides even in neoplastic tissues.

Positive_regulation (indicate) of Positive_regulation (co-existence) of Met-enkephalin associated with enkephalin and opioid

20) Confidence 0.47 Published 1984 Journal Acta Endocrinol. Section Abstract Doc Link 6495993 Disease Relevance 0.07 Pain Relevance 2.32

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