INT1196

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Context Info
Confidence 0.70
First Reported 1975
Last Reported 2010
Negated 5
Speculated 1
Reported most in Abstract
Documents 51
Total Number 52
Disease Relevance 15.99
Pain Relevance 28.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (POMC) cell-cell signaling (POMC) cytoplasm (POMC)
extracellular space (POMC) generation of precursor metabolites and energy (POMC) signal transduction (POMC)
Anatomy Link Frequency
plasma 27
cerebrospinal fluid 6
pituitary 4
epidermis 4
anterior pituitary 3
POMC (Homo sapiens)
POMC - A2M (1)
Pain Link Frequency Relevance Heat
Enkephalin 116 100.00 Very High Very High Very High
Opioid 49 100.00 Very High Very High Very High
melanocortin 1 receptor 6 100.00 Very High Very High Very High
Acupuncture 13 99.98 Very High Very High Very High
cINOD 1 99.98 Very High Very High Very High
Morphine 38 99.78 Very High Very High Very High
Serotonin 17 99.78 Very High Very High Very High
agonist 19 99.60 Very High Very High Very High
narcan 43 99.56 Very High Very High Very High
cocaine 11 99.14 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 42 100.00 Very High Very High Very High
Fetal Distress 5 100.00 Very High Very High Very High
INFLAMMATION 25 99.88 Very High Very High Very High
Disease 15 99.12 Very High Very High Very High
Carcinoid 5 99.00 Very High Very High Very High
Hypertension 10 98.24 Very High Very High Very High
Body Weight 1 97.52 Very High Very High Very High
Cancer 25 97.40 Very High Very High Very High
Headache Disorders 5 97.28 Very High Very High Very High
Hypoglycemia 1 97.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Surgery induced a large increase in plasma ACTH in group I (no CORT, no FENT); the mean plasma ACTH level was 57 +/- 14 (+/- SE) pmol/L 10 min after the start of surgery, and it peaked at 92 +/- 18 pmol/L 50 min after the start of surgery.
Positive_regulation (induced) of Positive_regulation (increase) of ACTH in plasma
1) Confidence 0.70 Published 1988 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2848053 Disease Relevance 0 Pain Relevance 0.22
RESULTS: A biphasic effect of ethanol on beta-endorphin release was found, with low to medium (1.2, 1.6, and 2.0 g) but not high (2.4 g) doses of ethanol, inducing a significant increase in the dialysate content of beta-endorphin.
Positive_regulation (inducing) of Positive_regulation (increase) of beta-endorphin
2) Confidence 0.68 Published 2009 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 19302084 Disease Relevance 0 Pain Relevance 0
The increase in ACTH was enhanced following naloxone.
Positive_regulation (enhanced) of Positive_regulation (increase) of ACTH associated with narcan
3) Confidence 0.62 Published 1987 Journal Acta Endocrinol. Section Abstract Doc Link 3035849 Disease Relevance 0 Pain Relevance 0.50
In the present study, however, the concentration of immunoreactive beta-endorphin-like material (eight patients) or leu-enkephalin (four patients) did not increase in cerebrospinal fluid of patients 5 min after induction of anesthesia with thiopental, 2-5 mg/kg and N2O 70%; after an additional 10 min, during which halothane was added; at 5, 15, and 60 min after surgical incision; or after 30 min in the recovery room.
Positive_regulation (concentration) of Positive_regulation (immunoreactive) of beta-endorphin in cerebrospinal fluid associated with anesthesia, halothane and enkephalin
4) Confidence 0.50 Published 1984 Journal Anesthesiology Section Abstract Doc Link 6318607 Disease Relevance 0.09 Pain Relevance 0.65
In the present study, however, the concentration of immunoreactive beta-endorphin-like material (eight patients) or leu-enkephalin (four patients) did not increase in cerebrospinal fluid of patients 5 min after induction of anesthesia with thiopental, 2-5 mg/kg and N2O 70%; after an additional 10 min, during which halothane was added; at 5, 15, and 60 min after surgical incision; or after 30 min in the recovery room.
Neg (not) Positive_regulation (increase) of Positive_regulation (concentration) of beta-endorphin in cerebrospinal fluid associated with anesthesia, halothane and enkephalin
5) Confidence 0.50 Published 1984 Journal Anesthesiology Section Abstract Doc Link 6318607 Disease Relevance 0.09 Pain Relevance 0.66
Parallel in vivo and in vitro studies indicate that nonsteroidal anti-inflammatory drug potentiation of endorphin release is mediated at the level of the pituitary corticotroph cell.
Positive_regulation (mediated) of Positive_regulation (potentiation) of endorphin in corticotroph associated with inflammation and cinod
6) Confidence 0.50 Published 1997 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 9246021 Disease Relevance 0.40 Pain Relevance 0.18
The enhancement of NK activity with beta-endorphin increased at all E:T ratios tested.
Positive_regulation (increased) of Positive_regulation (enhancement) of beta-endorphin
7) Confidence 0.50 Published 1983 Journal J. Immunol. Section Abstract Doc Link 6300232 Disease Relevance 0 Pain Relevance 0.68
The authors conclude that the reaction of the beta-endorphin system to acupuncture (sensory peripheral) stimulation in humans did not involve pituitary hypersecretion, and suggest that the increase of beta-endorphin binding to the tissue receptor sites seems to be responsible for the peripheral (plasma) B-EPLI decrease after acupuncture.
Spec (seems) Positive_regulation (responsible) of Positive_regulation (increase) of beta-endorphin in plasma associated with acupuncture
8) Confidence 0.50 Published 1983 Journal Acupunct Electrother Res Section Abstract Doc Link 6138943 Disease Relevance 0 Pain Relevance 0.73
On the basis of these and previous data it seems likely that the amnesic effect of ACTH and epinephrine could be mediated by endogenous beta-endorphin release.
Positive_regulation (mediated) of Positive_regulation (effect) of ACTH
9) Confidence 0.50 Published 1983 Journal Psychoneuroendocrinology Section Abstract Doc Link 6308701 Disease Relevance 0.23 Pain Relevance 0.24
Exercise induced a slight but significant increase in plasma concentrations of both ACTH (32% increase) and beta-endorphin (60% increase) in group A.
Positive_regulation (induced) of Positive_regulation (increase) of ACTH in plasma
10) Confidence 0.50 Published 1992 Journal Psychiatry Res Section Abstract Doc Link 1315442 Disease Relevance 0.30 Pain Relevance 0.07
Exercise induced a slight but significant increase in plasma concentrations of both ACTH (32% increase) and beta-endorphin (60% increase) in group A.
Positive_regulation (induced) of Positive_regulation (increase) of beta-endorphin in plasma
11) Confidence 0.50 Published 1992 Journal Psychiatry Res Section Abstract Doc Link 1315442 Disease Relevance 0.30 Pain Relevance 0.07
In normal subjects, the hCRH-induced ACTH, beta-endorphin, and cortisol increases were almost completely abolished by pretreatment with FK 33-824.
Positive_regulation (increases) of Positive_regulation (hCRH-induced) of ACTH
12) Confidence 0.50 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3023423 Disease Relevance 0.50 Pain Relevance 0.30
In normal subjects, the hCRH-induced ACTH, beta-endorphin, and cortisol increases were almost completely abolished by pretreatment with FK 33-824.
Positive_regulation (increases) of Positive_regulation (hCRH-induced) of beta-endorphin
13) Confidence 0.50 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3023423 Disease Relevance 0.50 Pain Relevance 0.30
Solar-simulated ultraviolet radiation-induced upregulation of the melanocortin-1 receptor, proopiomelanocortin, and alpha-melanocyte-stimulating hormone in human epidermis in vivo.
Positive_regulation (radiation-induced) of Positive_regulation (upregulation) of alpha-melanocyte-stimulating hormone in epidermis associated with melanocortin 1 receptor
14) Confidence 0.50 Published 2004 Journal J. Invest. Dermatol. Section Title Doc Link 15009732 Disease Relevance 0.39 Pain Relevance 0.30
DEX pretreatment dose dependently suppressed the restraint stress-induced increased plasma ACTH concentration.
Positive_regulation (stress-induced) of Positive_regulation (increased) of ACTH in plasma associated with stress and dexamethasone
15) Confidence 0.50 Published 2003 Journal Neuroendocrinology Section Abstract Doc Link 14688444 Disease Relevance 0.99 Pain Relevance 0.74
Acute cocaine administration (30 mg i.v.) significantly increased ACTH mean peak amplitude (P < .05), mean percent increase in peak amplitude, (P < .05), mean peak area (P < .04), total peak area (P < .04) and incremental peak height (P < .04).
Positive_regulation (increased) of Positive_regulation (increased) of ACTH associated with cocaine
16) Confidence 0.49 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932162 Disease Relevance 0.07 Pain Relevance 0.53
In the human, haloperidol increased concentrations of beta-endorphin after both 24 h and chronic treatment, while cholecystokinin was never affected.
Positive_regulation (increased) of Positive_regulation (concentrations) of beta-endorphin associated with cholecystokinin
17) Confidence 0.49 Published 1990 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 2143059 Disease Relevance 0 Pain Relevance 0.72
In rat, the serotonin receptor antagonist metergoline decreased basal concentrations of the opioid peptide and blocked the increase of beta-endorphin concentrations induced by the serotonin precursor 5-hydroxytryptophan and the tricyclic antidepressant chlorimipramine.
Positive_regulation (increase) of Positive_regulation (induced) of beta-endorphin associated with antagonist, tricyclic antidepressant, opioid and serotonin
18) Confidence 0.49 Published 1990 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 2143059 Disease Relevance 0 Pain Relevance 0.68
These results indicate the co-existence of Met-enkephalin, Leu-enkephalin, Met-enkephalin-Arg-Gly-Leu and Met-enkephalin-Arg-Phe in human phaeochromocytomas, suggesting the preservation of amino acid sequences of these four opioid peptides even in neoplastic tissues.
Positive_regulation (indicate) of Positive_regulation (co-existence) of Met-enkephalin associated with enkephalin and opioid
19) Confidence 0.47 Published 1984 Journal Acta Endocrinol. Section Abstract Doc Link 6495993 Disease Relevance 0.07 Pain Relevance 2.32
These results indicate the co-existence of Met-enkephalin, Leu-enkephalin, Met-enkephalin-Arg-Gly-Leu and Met-enkephalin-Arg-Phe in human phaeochromocytomas, suggesting the preservation of amino acid sequences of these four opioid peptides even in neoplastic tissues.
Positive_regulation (indicate) of Positive_regulation (co-existence) of Met-enkephalin associated with enkephalin and opioid
20) Confidence 0.47 Published 1984 Journal Acta Endocrinol. Section Abstract Doc Link 6495993 Disease Relevance 0.07 Pain Relevance 2.32

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