INT119606

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Context Info
Confidence 0.45
First Reported 2004
Last Reported 2010
Negated 5
Speculated 3
Reported most in Body
Documents 17
Total Number 20
Disease Relevance 17.96
Pain Relevance 3.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LEP) extracellular region (LEP) lipid metabolic process (LEP)
Anatomy Link Frequency
body 4
plasma 2
chondrocytes 2
cartilage 2
bowel 2
LEP (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 66 100.00 Very High Very High Very High
cINOD 11 100.00 Very High Very High Very High
addiction 2 100.00 Very High Very High Very High
Osteoarthritis 120 99.60 Very High Very High Very High
methadone 3 99.36 Very High Very High Very High
rheumatoid arthritis 6 98.52 Very High Very High Very High
spinal inflammation 8 98.20 Very High Very High Very High
dexamethasone 5 96.80 Very High Very High Very High
Serotonin 18 95.04 Very High Very High Very High
Inflammatory response 8 93.88 High High
Disease Link Frequency Relevance Heat
Mycobacterial Infection 246 100.00 Very High Very High Very High
INFLAMMATION 83 100.00 Very High Very High Very High
Metabolic Syndrome 58 100.00 Very High Very High Very High
Insulin Resistance 45 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 40 100.00 Very High Very High Very High
Opiate Addiction 2 100.00 Very High Very High Very High
Enteropathy 6 99.90 Very High Very High Very High
Osteoarthritis 117 99.60 Very High Very High Very High
Hypertension 48 99.44 Very High Very High Very High
Obesity 769 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Concept of selective leptin resistance
Regulation (selective) of Gene_expression (resistance) of leptin
1) Confidence 0.45 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993994 Disease Relevance 1.29 Pain Relevance 0
Although there were no differences between the two active groups on body fat, waist and hip size; or cholesterol (total, HDL, LDL) or leptin levels, the higher dosage did result in significantly greater reductions in body weight, and triglyceride, blood glucose, CRP and serotonin levels.
Neg (no) Regulation (differences) of Gene_expression (levels) of leptin in body associated with body weight, serotonin and disorder of lipid metabolism
2) Confidence 0.43 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2836327 Disease Relevance 0.59 Pain Relevance 0.19
bowel disease, no changes in leptin levels have been
Neg (no) Regulation (changes) of Gene_expression (levels) of leptin in bowel associated with enteropathy
3) Confidence 0.43 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804295 Disease Relevance 2.07 Pain Relevance 0.39
and low levels of leptin in TB patient group compared to control indicating no significant
Regulation (control) of Gene_expression (levels) of leptin associated with mycobacterial infection
4) Confidence 0.43 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804295 Disease Relevance 1.89 Pain Relevance 0.40
not know whether low leptin concentration has any contribution in
Spec (whether) Regulation (contribution) of Spec (whether) Gene_expression (concentration) of leptin
5) Confidence 0.43 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804295 Disease Relevance 0.82 Pain Relevance 0.05
probably low leptin concentrations may contribute to the increased
Spec (may) Regulation (contribute) of Gene_expression (concentrations) of leptin
6) Confidence 0.43 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804295 Disease Relevance 0.81 Pain Relevance 0.04
The expression of leptin and its functional receptor is strongly up-regulated in human OA cartilage and is related to the grade of cartilage destruction [9,10].
Regulation (regulated) of Gene_expression (expression) of leptin in cartilage associated with osteoarthritis
7) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.25 Pain Relevance 0.41
By contrast, leptin up-regulated gene expression in a dose-dependent manner in chondrocytes collected from obese OA patients as cells required an elevated level of leptin to be responsive (Figure 2).
Regulation (regulated) of Gene_expression (expression) of leptin in chondrocytes associated with obesity and osteoarthritis
8) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.27 Pain Relevance 0.13
[Serum leptin levels in patients with heroin addiction, the effect of one year of methadone substitution].
Regulation (effect) of Gene_expression (levels) of Serum leptin associated with addiction, methadone and opiate addiction
9) Confidence 0.39 Published 2004 Journal Vnitr Lek Section Title Doc Link 15214298 Disease Relevance 0.10 Pain Relevance 0.29
difference in the serum leptin concentration and TNF-?
Regulation (difference) of Gene_expression (concentration) of serum leptin
10) Confidence 0.38 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804295 Disease Relevance 0.70 Pain Relevance 0.03
1.66 ± 1.68 ng/mL, while the mean serum leptin levels of the controls were 15.74 ± 9.12 ng/mL, and the difference between the two groups was
Regulation (controls) of Gene_expression (levels) of serum leptin
11) Confidence 0.38 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804295 Disease Relevance 0.51 Pain Relevance 0.04
the ECoG recordings for their LEP characterizations, which might offer some
Spec (might) Regulation (offer) of Gene_expression (characterizations) of LEP
12) Confidence 0.35 Published 2007 Journal Computational Intelligence and Neuroscience Section Body Doc Link PMC2271124 Disease Relevance 0.09 Pain Relevance 0.09
Serum and plasma samples for the determination of fructosamine, proinsulin, insulin, C-peptide, adiponectin, leptin, NEFA, oxidised LDL were stored at ? 
Regulation (determination) of Gene_expression (fructosamine) of leptin in plasma
13) Confidence 0.28 Published 2010 Journal The British Journal of Nutrition Section Body Doc Link PMC2943747 Disease Relevance 0.26 Pain Relevance 0.07
Schmid et al. [59] demonstrated that sleep restriction led to a reduction in physical activity under free-living conditions, but there were no significant changes in food intake, hunger and appetite, and levels of leptin and ghrelin.
Neg (no) Regulation (changes) of Gene_expression (levels) of leptin
14) Confidence 0.23 Published 2010 Journal Journal of Obesity Section Body Doc Link PMC2925323 Disease Relevance 0.12 Pain Relevance 0
The aim of this study was to compare the effect of chronic inflammation on insulin resistance, serum leptin levels, and body composition (BC) in patients with ankylosing spondylitis (AS) and healthy controls.
Regulation (effect) of Gene_expression (levels) of leptin in body associated with spinal inflammation, inflammation and insulin resistance
15) Confidence 0.22 Published 2007 Journal Clin. Rheumatol. Section Abstract Doc Link 17260105 Disease Relevance 0.95 Pain Relevance 0.41
Figure 2 illustrates the main hypogonadal-obesity-insulin resistance connections and also includes other factors such as TNF-?
Regulation (illustrates) of Gene_expression (resistance) of hypogonadal-obesity-insulin associated with metabolic syndrome and insulin resistance
16) Confidence 0.20 Published 2010 Journal International Journal of Clinical Practice Section Body Doc Link PMC2948422 Disease Relevance 1.41 Pain Relevance 0.04
Testosterone has also been reported to regulate leptin mRNA expression [71].
Regulation (regulate) of Gene_expression (expression) of leptin mRNA
17) Confidence 0.19 Published 2005 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129146 Disease Relevance 0.97 Pain Relevance 0.08
Measurements of serum adipokines and markers of systemic inflammation revealed no significant change in serum adiponectin or leptin levels following overfeeding with either HC or HF diets.
Neg (no) Regulation (change) of Gene_expression (levels) of leptin associated with inflammation
18) Confidence 0.12 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2761378 Disease Relevance 0.10 Pain Relevance 0.05
A prospective study comparing ventilated infants with RSV infection and patients admitted to the ward showed that ventilated patients had higher prolactin and growth hormone levels and significantly lower leptin and insulin-like growth factor-1 levels.
Regulation (prolactin) of Gene_expression (levels) of leptin associated with infection and respiratory syncytial virus
19) Confidence 0.03 Published 2006 Journal Crit Care Section Body Doc Link PMC1751022 Disease Relevance 1.87 Pain Relevance 0
Furthermore, the replenishment of PGE1, PGE2 or PGF2alpha did not reverse the effects of AIDs on proliferation and expressions of p27(kip1) and cyclin D2 in hOBs.
Neg (not) Regulation (effects) of Gene_expression (expressions) of hOBs associated with cinod
20) Confidence 0.00 Published 2009 Journal Toxicology Section Abstract Doc Link 19428934 Disease Relevance 0.85 Pain Relevance 1.05

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