INT119639

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Context Info
Confidence 0.77
First Reported 2003
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 5
Total Number 11
Disease Relevance 2.96
Pain Relevance 1.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KIR3DL1)
Anatomy Link Frequency
T cells 4
myometrium 2
leukocyte 1
endometrium 1
KIR3DL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 276 98.04 Very High Very High Very High
tolerance 12 87.04 High High
rheumatoid arthritis 61 79.44 Quite High
Inflammation 28 71.84 Quite High
Arthritis 11 50.00 Quite Low
Dismenorea 9 50.00 Quite Low
cytokine 8 42.80 Quite Low
spondylitis 8 5.00 Very Low Very Low Very Low
Multiple sclerosis 5 5.00 Very Low Very Low Very Low
endometriosis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Low Back Pain 284 98.04 Very High Very High Very High
Dysmenorrhea 9 93.80 High High
Disease 82 93.72 High High
Autoimmune Disease 17 89.48 High High
Targeted Disruption 8 89.00 High High
Rheumatoid Arthritis 63 79.44 Quite High
INFLAMMATION 30 71.84 Quite High
Necrosis 2 69.56 Quite High
Cancer 2 69.20 Quite High
Aging 12 68.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The presence of one single additional HLA-B allele carrying the Bw4-I80 epitope in B*27-positive individuals could modulate the state of cell activation of NK (and/or T) cells in conjunction with the pattern of KIR gene expression.
Gene_expression (expression) of KIR
1) Confidence 0.77 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779409 Disease Relevance 0.57 Pain Relevance 0.54
The killer immunoglobulin-like receptor (KIR) genes encode a group of proteins that are expressed on natural killer (NK) cells and in some T cells that are located on chromosome 19q13.4 in the leukocyte receptor complex (reviewed in [4]).
Gene_expression (expressed) of KIR in leukocyte
2) Confidence 0.77 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779409 Disease Relevance 0.61 Pain Relevance 0.42
When both genotypes are present (3DS1/3DL1), the activating effect appears to be prevailing and so this genotype is increased in patients in both populations, significantly in Azoreans (p = 0.005).
Gene_expression (present) of 3DL1
3) Confidence 0.67 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779409 Disease Relevance 0.44 Pain Relevance 0.44
As a consequence, the influence of KIR genotypes on AS susceptibility would be mediated by a general imbalance between protective/inhibitory and risk/activating allotypes.


Gene_expression (genotypes) of KIR
4) Confidence 0.65 Published 2010 Journal Arthritis Rheum. Section Body Doc Link 20131260 Disease Relevance 0 Pain Relevance 0
The expression of KIR3DL1 may serve as a mechanism to control the activity of self-reactive T cells induced by arthritogenic peptides presented by ?
Gene_expression (expression) of KIR3DL1 in T cells
5) Confidence 0.60 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779409 Disease Relevance 0.60 Pain Relevance 0.51
Surface expressions of NK receptors, including killer cell immunoglobulin like receptors (NKB1, CD158a/h [KIR2DL1/KIR2DS1], CD158b/j [KIR2DL2/KIR2DL3/ KIR2DS2]) and the C-type lectin receptor CD94, were examined in 11 subsequent patients with increased levels of CD4+CD28- T cells.
Spec (examined) Gene_expression (expressions) of NKB1 in T cells
6) Confidence 0.46 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193730 Disease Relevance 0 Pain Relevance 0
Low levels of inhibitory NKB1 were detected on CD4+CD28- T cells (2.8 ± 4.4% versus 0.2 ± 0.1%; P = 0.003), whereas CD158a/h (KIR2DL1/ KIR2DS1) was detected neither on CD4+CD28- nor on CD4+CD28+ T cells (0.7 ± 1.9% versus 0.1 ± 0.1%).
Gene_expression (detected) of NKB1 in T cells
7) Confidence 0.40 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193730 Disease Relevance 0 Pain Relevance 0
The expression of KIRs, including NKB1, GL183, EB6 and CD94, on NK and T cells in myometrium and endometrium was examined by flow cytometry.
Spec (examined) Gene_expression (expression) of NKB1 in endometrium
8) Confidence 0.23 Published 2004 Journal Hum. Reprod. Section Body Doc Link 15217996 Disease Relevance 0.18 Pain Relevance 0
RESULTS: There was a decreased expression of NKB1 and GL183 on NK cells in the endometrium, but not in the myometrium, in women with adenomyosis.
Gene_expression (expression) of NKB1 in myometrium
9) Confidence 0.23 Published 2004 Journal Hum. Reprod. Section Body Doc Link 15217996 Disease Relevance 0.17 Pain Relevance 0
The expression of KIRs, including NKB1, GL183, EB6 and CD94, on NK and T cells in myometrium and endometrium was examined by flow cytometry.
Spec (examined) Gene_expression (expression) of NKB1 in myometrium
10) Confidence 0.08 Published 2004 Journal Hum. Reprod. Section Body Doc Link 15217996 Disease Relevance 0.18 Pain Relevance 0
In particular, CD4+CD28null T cells express immunoreceptors of the killer immunoglobulin-like receptor (KIR) family [53,56-58].
Gene_expression (express) of KIR in T cells
11) Confidence 0.06 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193735 Disease Relevance 0.21 Pain Relevance 0

General Comments

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