INT119641

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Context Info
Confidence 0.76
First Reported 2004
Last Reported 2006
Negated 0
Speculated 3
Reported most in Body
Documents 25
Total Number 48
Disease Relevance 33.20
Pain Relevance 3.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (EBAG9) plasma membrane (EBAG9)
Anatomy Link Frequency
immune cells 6
macrophages 3
endometrium 3
band 2
immune system 2
EBAG9 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 1094 99.36 Very High Very High Very High
tolerance 163 95.76 Very High Very High Very High
Pain 21 60.00 Quite High
Dismenorea 73 50.00 Quite Low
pain pelvic 21 44.36 Quite Low
Immobilon 25 37.88 Quite Low
Disease Link Frequency Relevance Heat
Cancer 205 100.00 Very High Very High Very High
Cicatrix 987 99.84 Very High Very High Very High
Endometrial Cancer 21 99.72 Very High Very High Very High
Cyst 63 99.44 Very High Very High Very High
Endometriosis 1890 99.36 Very High Very High Very High
Reprotox - General 3 317 98.68 Very High Very High Very High
Apoptosis 256 98.12 Very High Very High Very High
Abruptio Placentae 50 98.00 Very High Very High Very High
Fetal Death 175 97.88 Very High Very High Very High
Necrosis 71 94.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A correlation between RCAS1 expression and the infiltration by dNK cells in the human uterus found in early stage of pregnancy was observed by Oshima et al. [4].
Gene_expression (expression) of RCAS1 in uterus
1) Confidence 0.76 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1184098 Disease Relevance 0.44 Pain Relevance 0
In this study, in cases without maternal rejection RCAS1 was expressed mainly in trophoblast.
Gene_expression (expressed) of RCAS1
2) Confidence 0.76 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1184098 Disease Relevance 0.30 Pain Relevance 0.03
Methods: RCAS1 expression was evaluated by Western blot method with the use of monoclonal anti-RCAS1 antibody in 67 placental tissue samples.
Gene_expression (expression) of RCAS1
3) Confidence 0.76 Published 2005 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1184098 Disease Relevance 0.32 Pain Relevance 0
Our results indicate that alterations in RCAS1 expression may be involved in the changes of maternal immune system that take place during stillbirth.


Gene_expression (expression) of RCAS1 in immune system
4) Confidence 0.76 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1184098 Disease Relevance 0.35 Pain Relevance 0.05
Our previous studies confirmed the observation of decreased RCAS1 expression level during labor of spontaneous onset when compared to induced labor at term.
Gene_expression (expression) of RCAS1
5) Confidence 0.76 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1184098 Disease Relevance 0.46 Pain Relevance 0.04
The placental RCAS1 expression during stillbirth

Background: Independently of the fetal death cause the beginning and course of stillbirth is closely related with the growing cytotoxic activity at the maternal-fetal interface.

Gene_expression (expression) of RCAS1 associated with fetal death
6) Confidence 0.76 Published 2005 Journal Reprod Biol Endocrinol Section Title Doc Link PMC1184098 Disease Relevance 0.31 Pain Relevance 0
The decreased RCAS1 expression level seems to confirm the observation of higher dNK, NK activity, which might be clinically observed in the beginning of spontaneous labor, preterm labor or stillbirths [5].
Gene_expression (expression) of RCAS1 associated with reprotox - general 3 and pre-term labor
7) Confidence 0.76 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1184098 Disease Relevance 0.48 Pain Relevance 0.03
Lower placental RCAS1 expression in women with spontaneous beginning of stillbirth in comparison to induced stillbirths observed in our study seems to confirm this hypothesis.
Gene_expression (expression) of RCAS1 associated with reprotox - general 3
8) Confidence 0.76 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1184098 Disease Relevance 0.47 Pain Relevance 0.03
The aim of the present study was to investigate RCAS1 expression in placentas obtained following stillbirths or normal term births.
Spec (investigate) Gene_expression (expression) of RCAS1 in placentas associated with reprotox - general 3
9) Confidence 0.76 Published 2005 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1184098 Disease Relevance 0.28 Pain Relevance 0
In contrast, in cases with maternal rejection the expression of RCAS1 decreased strikingly.
Gene_expression (expression) of RCAS1
10) Confidence 0.76 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1184098 Disease Relevance 0.29 Pain Relevance 0.03
The alterations of RCAS1 protein expression in placental cells seem to determine the beginning of the labor and participate in the placental abruption.
Gene_expression (expression) of RCAS1 associated with abruptio placentae
11) Confidence 0.76 Published 2005 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1184098 Disease Relevance 0.27 Pain Relevance 0
RCAS1 expression was on comparable levels in scar and ovarian endometriosis (Table 4.)
Gene_expression (expression) of RCAS1 associated with endometriosis and cicatrix
12) Confidence 0.71 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.80 Pain Relevance 0.37
The decreased RCAS1 expression in scar and ovarian endometriomas in comparison to the eutopic secretory endometrium might result from the lower number of NK cells.
Gene_expression (expression) of RCAS1 in NK cells associated with endometriosis and cicatrix
13) Confidence 0.71 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.07 Pain Relevance 0.21
The RCAS1 expression observed in this study in both scar and ovarian endometriomas points to the possibility of inhibition of cytotoxic immune response, which might be secondary to the physiological ability of endometrial cells to regulate immune cell activity.
Gene_expression (expression) of RCAS1 in immune cell associated with endometriosis and cicatrix
14) Confidence 0.71 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.07 Pain Relevance 0.18
The expression of RCAS1 has been detected in the bone marrow, the Waldeyer's ring, the placenta, the endometrium, and the tubal mucosa thus indicating its role in immune cells regulation [11-13].
Gene_expression (expression) of RCAS1 in bone marrow
15) Confidence 0.71 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 0.82 Pain Relevance 0.06
In our previous report a significantly lower RCAS1 expression was noticed in ovarian endometriosis in comparison to endometrial carcinoma [10].
Gene_expression (expression) of RCAS1 associated with endometriosis and endometrial cancer
16) Confidence 0.71 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.16 Pain Relevance 0.17
RCAS1 expression was growing in the eutopic endometrium simultaneously with the growth of the number of CD56-positive cells and CD69 antigen expression.
Gene_expression (expression) of RCAS1 in endometrium
17) Confidence 0.71 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.07 Pain Relevance 0.14
Statistically significant lower RCAS1 expression was observed in ovarian endometriosis than in the control group (p = 0.002).
Gene_expression (expression) of RCAS1 associated with endometriosis
18) Confidence 0.71 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.69 Pain Relevance 0.34
Similarly, statistically significant lower RCAS1 expression was identified in scar endometriosis in comparison to the control group (p = 0.002).
Gene_expression (expression) of RCAS1 associated with endometriosis and cicatrix
19) Confidence 0.71 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.68 Pain Relevance 0.34
The 32 kDa RCAS1 band intensities in reference and in unknown lanes were then calculated and expressed in pixel number units.
Gene_expression (expressed) of RCAS1 in band
20) Confidence 0.66 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1184098 Disease Relevance 0 Pain Relevance 0

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