INT119651

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Context Info
Confidence 0.32
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 4.65
Pain Relevance 7.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc6a4) endosome (Slc6a4) transport (Slc6a4)
plasma membrane (Slc6a4)
Anatomy Link Frequency
raphe nucleus 3
neuron 2
blood platelets 2
adult brain 1
brain 1
Slc6a4 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 220 100.00 Very High Very High Very High
sSRI 412 99.98 Very High Very High Very High
fluoxetine 828 99.96 Very High Very High Very High
Raphe 83 99.68 Very High Very High Very High
Desipramine 2 97.28 Very High Very High Very High
imagery 33 95.80 Very High Very High Very High
monoamine 11 92.56 High High
depression 90 89.00 High High
tricyclic antidepressant 16 86.08 High High
cytokine 2 84.76 Quite High
Disease Link Frequency Relevance Heat
Body Weight 56 99.70 Very High Very High Very High
Coronary Heart Disease 44 92.68 High High
Anxiety Disorder 141 89.88 High High
Depression 99 89.00 High High
Hypertrophy 16 86.52 High High
Spontaneous Abortion 16 84.72 Quite High
Hyperplasia 2 83.04 Quite High
Obsessive-compulsive Disorder 8 79.80 Quite High
Eating Disorder 24 79.44 Quite High
Panic Disorder 8 78.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SSRIs, like fluoxetine and fluvoxamine, inhibit the reuptake of serotonin (5-hydroxytryptamine or 5-HT) into the presynaptic neuron by binding to the serotonin transporter (5-HTT), which results in an increase of synaptic serotonin levels.
serotonin transporter Binding (binding) of in neuron associated with serotonin, ssri and fluoxetine
1) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518512 Disease Relevance 0.72 Pain Relevance 0.79
The effect of two psychotropics and one narcotic on the binding of [(123)I]ADAM to SERT was also studied.
SERT Binding (binding) of
2) Confidence 0.31 Published 2004 Journal Nucl. Med. Biol. Section Abstract Doc Link 15219272 Disease Relevance 0 Pain Relevance 0.42
A large amount of serotonin is stored in blood platelets, bounded to the serotonin transporter (5-HTT).
serotonin transporter Binding (bounded) of in blood platelets associated with serotonin
3) Confidence 0.31 Published 2010 Journal J Transl Med Section Body Doc Link PMC2907326 Disease Relevance 1.03 Pain Relevance 0.49
SSRIs, like fluoxetine and fluvoxamine, inhibit the reuptake of serotonin (5-hydroxytryptamine or 5-HT) into the presynaptic neuron by binding to the serotonin transporter (5-HTT), which results in an increase of synaptic serotonin levels.
5-HTT Binding (binding) of in neuron associated with serotonin, ssri and fluoxetine
4) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518512 Disease Relevance 0.72 Pain Relevance 0.79
The observed changes in 5-HTT binding in the raphe nucleus at P20 and adulthood demonstrates that fluoxetine exposure during fetal development permanently changes the serotonin homeostasis, whereas prenatal fluvoxamine exposure did not.
5-HTT Binding (binding) of in raphe nucleus associated with serotonin, raphe and fluoxetine
5) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518512 Disease Relevance 0.42 Pain Relevance 0.75
Serotonin transporter binding was analyzed in the dorsal raphe nucleus of mice at P20 and P90 treated with saline (N?
Serotonin transporter Binding (binding) of in raphe nucleus associated with raphe and serotonin
6) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518512 Disease Relevance 0 Pain Relevance 0.48
After prenatal exposure to fluoxetine, 5-HTT binding decreased significantly in the raphe nucleus at P20 (40%; N?
5-HTT Binding (binding) of in raphe nucleus associated with raphe and fluoxetine
7) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518512 Disease Relevance 0.11 Pain Relevance 0.80
Since SSRIs bind specifically to the 5-HTT, 5-HTT levels may be permanently altered as a consequence of SSRI treatment during fetal brain development.
5-HTT Binding (bind) of in brain associated with ssri
8) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518512 Disease Relevance 0.14 Pain Relevance 0.67
A large amount of serotonin is stored in blood platelets, bounded to the serotonin transporter (5-HTT).
5-HTT Binding (bounded) of in blood platelets associated with serotonin
9) Confidence 0.27 Published 2010 Journal J Transl Med Section Body Doc Link PMC2907326 Disease Relevance 1.03 Pain Relevance 0.49
To determine whether the decreased 5-HTT levels in the raphe nucleus after prenatal fluoxetine treatment (0.8 mg/kg/day) are dose-dependent, autoradiography using [N-methyl-3H]-citalopram was performed on adult brain tissue of mice prenatally exposed to different concentrations of fluoxetine (0.3, 0.6 and 0.8 mg/kg/day; Fig. 6). 5-HTT binding was significantly decreased in the offspring exposed to 0.8 (N?
5-HTT Binding (binding) of in adult brain associated with raphe and fluoxetine
10) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518512 Disease Relevance 0.11 Pain Relevance 1.08
Data of body weight, Wt/r ratios, 5-HTT binding and behavioral performance were analyzed using an one-way analysis of variance (ANOVA), followed by Bonferroni multiple comparison test when appropriate.
5-HTT Binding (binding) of in body associated with body weight
11) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518512 Disease Relevance 0.18 Pain Relevance 0.25
Panel B of Figure 4 shows that varying SERT activity over this range has a large effect (.5 ?
SERT Binding (activity) of
12) Confidence 0.17 Published 2010 Journal Theor Biol Med Model Section Body Doc Link PMC2942809 Disease Relevance 0.19 Pain Relevance 0.07

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