INT119669

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Context Info
Confidence 0.49
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.95
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 1
choroid plexus 1
white matter 1
Igh-VS107 (Mus musculus)
Pain Link Frequency Relevance Heat
intrathecal 2 99.98 Very High Very High Very High
imagery 5 99.64 Very High Very High Very High
Neuritis 9 98.44 Very High Very High Very High
Multiple sclerosis 5 97.40 Very High Very High Very High
ketamine 6 89.60 High High
anesthesia 2 85.28 High High
cytokine 9 58.64 Quite High
Spinal cord 5 57.64 Quite High
Hippocampus 2 56.80 Quite High
Sciatic nerve 1 28.80 Quite Low
Disease Link Frequency Relevance Heat
Bacillus Anthracis Infection 26 100.00 Very High Very High Very High
Septic Shock 20 99.44 Very High Very High Very High
Optic Neuritis 9 98.44 Very High Very High Very High
Demyelinating Disease 6 97.40 Very High Very High Very High
Body Weight 2 96.12 Very High Very High Very High
Infection 127 95.16 Very High Very High Very High
Neurological Disease 4 94.72 High High
Apoptosis 16 94.68 High High
Gastroenteritis 24 90.72 High High
Viral Infection 5 89.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Detection of bovine IgG in tissue homogenates and sera
Gene_expression (Detection) of IgG
1) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964324 Disease Relevance 0.47 Pain Relevance 0.06
Furthermore, when compared with control mice, immunized mice had higher total IgG levels as well as higher anti-E1 specific, anti-E2 specific, and anti-C specific IgG antibodies, suggesting a strong humoral immune response (Figure 3) and also specificity for the antigens encoded in the vaccine constructs (Figure 4).
Gene_expression (levels) of IgG
2) Confidence 0.15 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2860491 Disease Relevance 0.19 Pain Relevance 0
Furthermore, when compared with control mice, immunized mice had higher total IgG levels as well as higher anti-E1 specific, anti-E2 specific, and anti-C specific IgG antibodies, suggesting a strong humoral immune response (Figure 3) and also specificity for the antigens encoded in the vaccine constructs (Figure 4).
Gene_expression (antibodies) of IgG
3) Confidence 0.15 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2860491 Disease Relevance 0.20 Pain Relevance 0
4000 (Novus Biologicals), Cy3-conjugated anti mouse IgG and Cy3-conjugated anti-rabbit 1?
Gene_expression (conjugated) of IgG
4) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844429 Disease Relevance 0 Pain Relevance 0.03
These assays detect virus-specific IgM and IgG, however the sensitivity and specificity of these assays has been poorly characterized.
Gene_expression (detect) of IgG
5) Confidence 0.13 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2860491 Disease Relevance 0.66 Pain Relevance 0.06
As evidence that anti-INA Ab indeed penetrated the BBB and gained access to its cognate CNS targets, it was observed that there was IgG staining of the choroid plexus in INA+LPS treated mice (Figure 5A).
Gene_expression (staining) of IgG in choroid plexus
6) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886066 Disease Relevance 0.40 Pain Relevance 0.11
Twenty-one subjects with ON had white matter lesions on magnetic resonance imaging (MRI) and intrathecal synthesis of oligoclonal IgG bands (OB) consistent with being at high risk of progression to MS; eight of whom later were diagnosed with clinically definite MS (CDMS).
Gene_expression (synthesis) of IgG in white matter associated with multiple sclerosis, imagery, neuritis and intrathecal
7) Confidence 0.03 Published 2004 Journal Mult. Scler. Section Abstract Doc Link 15222688 Disease Relevance 1.14 Pain Relevance 0.98
Complete blood counts with white blood cell differential counts as well as serum concentrations of IgM and IgG were determined from blood collected on days 14, 42, and 70.
Gene_expression (concentrations) of IgG in blood
8) Confidence 0.03 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2543000 Disease Relevance 0 Pain Relevance 0.08
All of the vaccines we examined induced significant levels of serum antibodies (IgM, IgG), equivalent to historic data and neutralizing antibody titers were observed for anthrax, BoNT/A, and toxic shock vaccines.
Gene_expression (anthrax) of IgG associated with bacillus anthracis infection and septic shock
9) Confidence 0.01 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2543000 Disease Relevance 0.88 Pain Relevance 0

General Comments

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